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BIOMD0000000138 - Tabak2007_dopamine

 

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Reference Publication
Publication ID: 17058022
Tabak J, Toporikova N, Freeman ME, Bertram R.
Low dose of dopamine may stimulate prolactin secretion by increasing fast potassium currents.
J Comput Neurosci 2007 Apr; 22(2): 211-222
Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA. joel@neuro.fsu.edu  [more]
Model
Original Model: http://www.math.fsu.edu/%7...
Submitter: Enuo He
Submission ID: MODEL6090663405
Submission Date: 08 Aug 2007 07:35:09 UTC
Last Modification Date: 01 Apr 2014 18:01:13 UTC
Creation Date: 02 Aug 2007 10:34:59 UTC
Encoders:  Enuo He
set #1
bqbiol:isVersionOf Gene Ontology regulation of prolactin signaling pathway
Gene Ontology potassium channel activity
Gene Ontology dopamine secretion
bqbiol:hasTaxon Taxonomy Chordata
set #2
bqbiol:hasProperty Mathematical Modelling Ontology MAMO_0000046
Notes

The model is encoded according to the paper Low dose of dopamine may stimulate prolactin secretion by increasing fast potassium currents Figure5 has been reproduced by MathSBML. One need to change the value of ga in order to get the three correct results.

the xppaut file of the model is avaiable on the following address offered by the author , http://www.math.fsu.edu/%7Ebertram/software/pituitary/JCNS_07.ode


To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.


To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 17058022 Submission Date: 08 Aug 2007 07:35:09 UTC Last Modification Date: 01 Apr 2014 18:01:13 UTC Creation Date: 02 Aug 2007 10:34:59 UTC
Mathematical expressions
Reactions
reaction_0000004      
Rules
Assignment Rule (variable: phik) Assignment Rule (variable: phia) Assignment Rule (variable: phih) Assignment Rule (variable: phif)
Assignment Rule (variable: phical) Assignment Rule (variable: ica) Assignment Rule (variable: cinf) Assignment Rule (variable: isk)
Assignment Rule (variable: ibk) Assignment Rule (variable: ikdr) Assignment Rule (variable: ia) Assignment Rule (variable: ik)
Rate Rule (variable: V) Rate Rule (variable: n) Rate Rule (variable: h)  
Physical entities
Compartments Species
cell calcium concentration    
Global parameters
reversal potential for Ca reversal potential for K membrane capacitance gk
gcal gsk ga gf
vn va vm vh
vf sn sa sm
sh sf taun tauh
lambda kc ks ff
alpha phik phia phih
phif phical cinf ica
isk ibk ikdr ia
ik n h V
Reactions (1)
 
 reaction_0000004  → [calcium concentration];  
 
Rules (15)
 
 Assignment Rule (name: phik) phik = 1/(1+exp((vn-V)/sn))
 
 Assignment Rule (name: phia) phia = 1/(1+exp((va-V)/sa))
 
 Assignment Rule (name: phih) phih = 1/(1+exp((V-vh)/sh))
 
 Assignment Rule (name: phif) phif = 1/(1+exp((vf-V)/sf))
 
 Assignment Rule (name: phical) phical = 1/(1+exp((vm-V)/sm))
 
 Assignment Rule (name: ica) ica = gcal*phical*(V-vca)
 
 Assignment Rule (name: cinf) cinf = c^2/(c^2+ks^2)
 
 Assignment Rule (name: isk) isk = gsk*cinf*(V-vk)
 
 Assignment Rule (name: ibk) ibk = gf*phif*(V-vk)
 
 Assignment Rule (name: ikdr) ikdr = gk*n*(V-vk)
 
 Assignment Rule (name: ia) ia = ga*phia*h*(V-vk)
 
 Assignment Rule (name: ik) ik = isk+ibk+ikdr+ia
 
 Rate Rule (name: V) d [ V] / d t= (-(ica+ik))/Cm
 
 Rate Rule (name: n) d [ n] / d t= lambda*(phik-n)/taun
 
 Rate Rule (name: h) d [ h] / d t= (phih-h)/tauh
 
  Spatial dimensions: 3.0  Compartment size: 1.0
 
 calcium concentration
Compartment: cell
Initial concentration: 0.3
 
Global Parameters (40)
 
   reversal potential for Ca
Value: 50.0
Constant
 
   reversal potential for K
Value: -75.0
Constant
 
   membrane capacitance
Value: 10.0
Constant
 
   gk
Value: 4.0
Constant
 
   gcal
Value: 2.0
Constant
 
   gsk
Value: 1.7
Constant
 
 ga
Constant
 
   gf
Constant
 
   vn
Value: -5.0
Constant
 
   va
Value: -20.0
Constant
 
   vm
Value: -20.0
Constant
 
   vh
Value: -60.0
Constant
 
   vf
Value: -20.0
Constant
 
   sn
Value: 10.0
Constant
 
   sa
Value: 10.0
Constant
 
   sm
Value: 12.0
Constant
 
   sh
Value: 5.0
Constant
 
   sf
Value: 5.6
Constant
 
   taun
Value: 30.0
Constant
 
   tauh
Value: 20.0
Constant
 
   lambda
Value: 0.7
Constant
 
   kc
Value: 0.16
Constant
 
   ks
Value: 0.5
Constant
 
   ff
Value: 0.01
Constant
 
   alpha
Value: 0.0015
Constant
 
   phik
Value: NaN
 
   phia  
 
   phih
Value: NaN
 
   phif
Value: NaN
 
   phical
Value: NaN
 
   cinf
Value: NaN
 
   ica
Value: NaN
 
   isk
Value: NaN
 
   ibk
Value: NaN
 
   ikdr
Value: NaN
 
   ia
Value: NaN
 
   ik
Value: NaN
 
   n
Value: 0.1
 
   h
Value: 0.1
 
   V
Value: -60.0
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000138

Curator's comment: (updated: 10 Aug 2007 18:02:40 BST)

Figure5 has been reproduced by MathSBML.

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