BioModels Database logo

BioModels Database

spacer

BIOMD0000000117 - Dupont1991_CaOscillation

 

 |   |   |  Send feedback
Reference Publication
Publication ID: 1647878
Dupont G, Berridge MJ, Goldbeter A.
Signal-induced Ca2+ oscillations: properties of a model based on Ca(2+)-induced Ca2+ release.
Cell Calcium 1991 Feb-Mar; 12(2-3): 73-85
Faculté des Sciences, Université Libre de Bruxelles, Belgium.  [more]
Model
Original Model: http://senselab.med.yale.e...
Submitter: Enuo He
Submission ID: MODEL0466937756
Submission Date: 05 Jun 2007 21:06:57 UTC
Last Modification Date: 05 Jul 2012 16:48:14 UTC
Creation Date: 22 May 2007 13:36:51 UTC
Encoders:  Enuo He
set #1
bqbiol:isVersionOf Gene Ontology calcium-mediated signaling
Gene Ontology calcium-induced calcium release activity
bqbiol:occursIn Taxonomy cellular organisms
Notes

This model is according to the paper Signal-induced Ca2+ oscillations: Properties of a model based on Ca2+-induced Ca2+ release. Figure4B in the paper has been reproduced by RoadRunner and MathSBML. Damped Ca2+ oscillations elicited by a transient pulse of InsP3 applied intracellularly to a resting, non-oscillatory cell.


To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.


To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 1647878 Submission Date: 05 Jun 2007 21:06:57 UTC Last Modification Date: 05 Jul 2012 16:48:14 UTC Creation Date: 22 May 2007 13:36:51 UTC
Mathematical expressions
Reactions
InsP3 modulated release of Ca from the InsP3 sensitive store Constant input of Ca from the extracellular medium Leak Ca from pool to cytosol Pumping Ca into the InsP3-insensitive store
Release of Ca from the pool into the cytosol Transport of cytosolic ca into the extracellular medium    
Rules
Assignment Rule (variable: beta)      
Events
event_0000001      
Physical entities
Compartments Species
extracellular      
Cytosol Ca in the cytosol    
intracellular_Ca_storepool Ca in the InsP3-insensitive pool    
Global parameters
v0 v1 VM2 VM3
KR KA K2 kf
k n m p
stimulation time beta flag  
Reactions (6)
 
 InsP3 modulated release of Ca from the InsP3 sensitive store  → [Ca in the cytosol];  
 
 Constant input of Ca from the extracellular medium  → [Ca in the cytosol];  
 
 Leak Ca from pool to cytosol [Ca in the InsP3-insensitive pool] → [Ca in the cytosol];  
 
 Pumping Ca into the InsP3-insensitive store [Ca in the cytosol] → [Ca in the InsP3-insensitive pool];  
 
 Release of Ca from the pool into the cytosol [Ca in the InsP3-insensitive pool] → [Ca in the cytosol];  
 
 Transport of cytosolic ca into the extracellular medium [Ca in the cytosol] → ;  
 
Rules (1)
 
 Assignment Rule (name: beta) beta = flag*0.96*exp((-0.2)*(time-tstim))
 
Events (1)
 
 event_0000001
flag = 1
 
  Spatial dimensions: 3.0  Compartment size: 1.0
  Spatial dimensions: 3.0  Compartment size: 1.0
 
 Ca in the cytosol
Compartment: Cytosol
Initial concentration: 0.1
 
  Spatial dimensions: 3.0  Compartment size: 1.0
 
 Ca in the InsP3-insensitive pool
Compartment: intracellular_Ca_storepool
Initial concentration: 1.4
 
Global Parameters (15)
 
   v0
Value: 1.0
Constant
 
   v1
Value: 7.3
Constant
 
   VM2
Value: 65.0
Constant
 
   VM3
Value: 500.0
Constant
 
   KR
Value: 2.0
Constant
 
   KA
Value: 0.9
Constant
 
   K2
Value: 1.0
Constant
 
   kf
Value: 1.0
Constant
 
   k
Value: 10.0
Constant
 
   n
Value: 2.0
Constant
 
   m
Value: 2.0
Constant
 
   p
Value: 4.0
Constant
 
   stimulation time
Value: 4.0
Constant
 
  beta  
 
 flag  
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000117

Curator's comment: (updated: 14 Aug 2007 22:22:13 BST)

Figure4B has been simulated by MathSBML.

spacer
spacer