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BIOMD0000000101 - Vilar2006_TGFbeta


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Reference Publication
Publication ID: 16446785
Vilar JM, Jansen R, Sander C.
Signal processing in the TGF-beta superfamily ligand-receptor network.
PLoS Comput. Biol. 2006 Jan; 2(1): e3
Integrative Biological Modeling Laboratory, Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.  [more]
Original Model: BIOMD0000000101.origin
Submitter: Katja Wegner
Submission ID: MODEL4023382414
Submission Date: 22 Mar 2007 22:55:11 UTC
Last Modification Date: 05 Jul 2012 14:45:52 UTC
Creation Date: 28 Nov 2006 18:39:38 UTC
Encoders:  Harish Dharuri
set #1
bqbiol:isVersionOf Gene Ontology transforming growth factor beta receptor signaling pathway
bqbiol:hasPart Reactome REACT_6844.3
bqbiol:hasTaxon Taxonomy cellular organisms
set #2
bqbiol:hasPart KEGG Pathway TGF-beta signaling pathway - Homo sapiens (human)

The model reproduces Fig 5A of the paper. The ligand concentration is increased from 3E-5 to 0.01 at time t=2500 to ensure that the system reaches steady state. Hence, the time t=0 of the paper corresponds to t=2500 in the model. The peak value of the active ligand receptor complex is off by a value of 1.25, the authors have stated that this discrepancy is due to the fact that the figure in the paper corresponds to a slightly different parameter set. The model was successfully tested on MathSBML.

To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.

To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Publication ID: 16446785 Submission Date: 22 Mar 2007 22:55:11 UTC Last Modification Date: 05 Jul 2012 14:45:52 UTC Creation Date: 28 Nov 2006 18:39:38 UTC
Mathematical expressions
Ligand receptor complex formation Ligand receptor complex constitutive degradation Ligand independent complex degradation Ligand receptor complex internalization
RI synthesis RI constitutive degradation RI internalization RI recycling
Ligand Receptor complex recycling RII synthesis RII constitutive degradation RII internalization
RII recycling      
Physical entities
Compartments Species
Plasma membrane Receptor 1 Receptor 2 ligand receptor complex-plasma membrane
Endosome ligand receptor complex-endosome Receptor 1-endosome Receptor 2 endosome
Global parameters
ka ligand kcd klid
ki pRI kr alpha
Reactions (13)
 Ligand receptor complex formation [Receptor 2] + [Receptor 1] → [ligand receptor complex-plasma membrane];  
 Ligand receptor complex constitutive degradation [ligand receptor complex-plasma membrane] → ;  
 Ligand independent complex degradation [ligand receptor complex-plasma membrane] → ;  
 Ligand receptor complex internalization [ligand receptor complex-plasma membrane] → [ligand receptor complex-endosome];  
 RI synthesis  → [Receptor 1];  
 RI constitutive degradation [Receptor 1] → ;  
 RI internalization [Receptor 1] → [Receptor 1-endosome];  
 RI recycling [Receptor 1-endosome] → [Receptor 1];  
 Ligand Receptor complex recycling [ligand receptor complex-endosome] → [Receptor 1] + [Receptor 2];  
 RII synthesis  → [Receptor 2];  
 RII constitutive degradation [Receptor 2] → ;  
 RII internalization [Receptor 2] → [Receptor 2 endosome];  
 RII recycling [Receptor 2 endosome] → [Receptor 2];  
Events (1)
ligand = 0.01
 Plasma membrane Spatial dimensions: 3.0  Compartment size: 1.0
 Receptor 1
Compartment: Plasma membrane
Initial amount: 20.0
 Receptor 2
Compartment: Plasma membrane
Initial amount: 20.0
 ligand receptor complex-plasma membrane
Compartment: Plasma membrane
Initial amount: 0.0
 Endosome Spatial dimensions: 3.0  Compartment size: 1.0
 ligand receptor complex-endosome
Compartment: Endosome
Initial amount: 40.0
 Receptor 1-endosome
Compartment: Endosome
Initial amount: 0.0
 Receptor 2 endosome
Compartment: Endosome
Initial amount: 0.0
Global Parameters (9)
Value: 1.0
Value: 3.0E-5
Value: 0.0277777778
Value: 0.25
Value: 0.3333333333333
Value: 8.0
Value: 0.0333333333333333
Value: 1.0
Value: 4.0
Representative curation result(s)
Representative curation result(s) of BIOMD0000000101

Curator's comment: (updated: 01 May 2007 21:56:32 BST)

Simulation result corresponds to Fig 5A of the paper. Plot generated by MathSBML.