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BIOMD0000000098 - Goldbeter1990_CalciumSpike_CICR

 

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Reference Publication
Publication ID: 2304911
Goldbeter A, Dupont G, Berridge MJ.
Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation.
Proc. Natl. Acad. Sci. U.S.A. 1990 Feb; 87(4): 1461-1465
Faculté des Sciences, Université Libre de Bruxelles, Belgium.  [more]
Model
Original Model: BIOMD0000000098.origin
Submitter: Harish Dharuri
Submission ID: MODEL4519937652
Submission Date: 21 Mar 2007 23:52:01 UTC
Last Modification Date: 24 May 2014 17:41:51 UTC
Creation Date: 21 Mar 2007 15:41:17 UTC
Encoders:  Harish Dharuri
set #1
bqmodel:isDerivedFrom PubMed 6281582
set #2
bqbiol:hasProperty Mathematical Modelling Ontology MAMO_0000046
set #3
bqbiol:isVersionOf Gene Ontology calcium-mediated signaling
Gene Ontology calcium ion transport
Gene Ontology inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
set #4
bqbiol:hasTaxon Taxonomy cellular organisms
Notes

The model reproduces the time profile of cytosolic and intracellular calcium as depicted in the upper panel of Fig 2 in the paper. The model was successfully tested on MathSBML and Jarnac.

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.
For more information see the terms of use.
To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

Model
Publication ID: 2304911 Submission Date: 21 Mar 2007 23:52:01 UTC Last Modification Date: 24 May 2014 17:41:51 UTC Creation Date: 21 Mar 2007 15:41:17 UTC
Mathematical expressions
Reactions
Ca influx InsP3 dependent Ca influx ATP driven Ca pumping into store ATP driven pumping into cytosol
Ca leak Ca efflux    
Physical entities
Compartments Species
cytosol Z    
store Y    
Global parameters
v0 v1 beta Vm2
n K2 Vm3 m
Kr Ka kf k
p      
Reactions (6)
 
 Ca influx  → [Z];  
 
 InsP3 dependent Ca influx  → [Z];  
 
 ATP driven Ca pumping into store [Z] → [Y];  
 
 ATP driven pumping into cytosol [Y] → [Z];  
 
 Ca leak [Y] → [Z];  
 
 Ca efflux [Z] → ;  
 
 cytosol Spatial dimensions: 3.0  Compartment size: 1.0
 
 Z
Compartment: cytosol
Initial concentration: 0.15
 
 store Spatial dimensions: 3.0  Compartment size: 1.0
 
 Y
Compartment: store
Initial concentration: 1.6
 
Global Parameters (13)
 
   v0
Value: 1.0   (Units: uM_per_sec)
Constant
 
   v1
Value: 7.3   (Units: uM_per_sec)
Constant
 
   beta
Value: 0.301   (Units: dimensionless)
Constant
 
   Vm2
Value: 65.0   (Units: uM_per_sec)
Constant
 
   n
Value: 2.0   (Units: dimensionless)
Constant
 
   K2
Value: 1.0   (Units: uM)
Constant
 
   Vm3
Value: 500.0   (Units: uM_per_sec)
Constant
 
   m
Value: 2.0   (Units: dimensionless)
Constant
 
   Kr
Value: 2.0   (Units: uM)
Constant
 
   Ka
Value: 0.9   (Units: uM)
Constant
 
   kf
Value: 1.0   (Units: sec_inv)
Constant
 
   k
Value: 10.0   (Units: sec_inv)
Constant
 
   p
Value: 4.0   (Units: dimensionless)
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000098

Curator's comment: (updated: 21 Mar 2007 23:39:24 GMT)

The simulation result reproduces the calcium concentrations in the cytosol and the intracellular store as depicted in the upper panel of Fig 2. Result shown was obtained from MathSBML.

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