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BIOMD0000000098 - Goldbeter1990_CalciumSpike_CICR

  
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Reference Publication
Publication ID: 2304911
Goldbeter A, Dupont G, Berridge MJ.
Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation.
Proc Natl Acad Sci U S A 1990 Feb;87(4):1461-5.
Faculté des Sciences, Université Libre de Bruxelles, Belgium.  [more]
Model
Original Model: BIOMD0000000098.xml.origin
Submitter: Harish Dharuri
Submission ID: MODEL4519937652
Submission Date: 21 Mar 2007 23:52:01 UTC
Last Modification Date: 05 Oct 2009 11:43:57 UTC
Creation Date: 21 Mar 2007 15:41:17 UTC
Encoders:  Harish Dharuri
set #1
bqbiol:isVersionOf Gene Ontology calcium ion transport
Gene Ontology inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
Notes

The model reproduces the time profile of cytosolic and intracellular calcium as depicted in the upper panel of Fig 2 in the paper. The model was successfully tested on MathSBML and Jarnac.

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2012 The BioModels.net Team.
For more information see the terms of use.
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 2304911 Submission Date: 21 Mar 2007 23:52:01 UTC Last Modification Date: 05 Oct 2009 11:43:57 UTC Creation Date: 21 Mar 2007 15:41:17 UTC
Mathematical expressions
Reactions
Ca influx InsP3 dependent Ca influx ATP driven Ca pumping into store ATP driven pumping into cytosol
Ca leak Ca efflux    
Physical entities
Compartments Species
cytosol Z    
store Y    
Global parameters
v0 v1 beta Vm2
n K2 Vm3 m
Kr Ka kf k
p      
Reactions (6)
 
 Ca influx  → [Z];  
 
 InsP3 dependent Ca influx  → [Z];  
 
 ATP driven Ca pumping into store [Z] → [Y];  
 
 ATP driven pumping into cytosol [Y] → [Z];  
 
 Ca leak [Y] → [Z];  
 
 Ca efflux [Z] → ;  
 
 cytosol Spatial dimensions: 3  Compartment size: 1.0
 
 Z
Compartment: cytosol
Initial concentration: 0.15
 
 store Spatial dimensions: 3  Compartment size: 1.0
 
 Y
Compartment: store
Initial concentration: 1.6
 
Global Parameters (13)
 
   v0
Value: 1.0   (Units: uM_per_sec)
Constant
 
   v1
Value: 7.3   (Units: uM_per_sec)
Constant
 
   beta
Value: 0.301
Constant
 
   Vm2
Value: 65.0   (Units: uM_per_sec)
Constant
 
   n
Value: 2.0
Constant
 
   K2
Value: 1.0   (Units: uM)
Constant
 
   Vm3
Value: 500.0   (Units: uM_per_sec)
Constant
 
   m
Value: 2.0
Constant
 
   Kr
Value: 2.0   (Units: uM)
Constant
 
   Ka
Value: 0.9   (Units: uM)
Constant
 
   kf
Value: 1.0   (Units: sec_inv)
Constant
 
   k
Value: 10.0   (Units: sec_inv)
Constant
 
   p
Value: 4.0
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000098

Curator's comment: (updated: 21 Mar 2007 23:39:24 GMT)

The simulation result reproduces the calcium concentrations in the cytosol and the intracellular store as depicted in the upper panel of Fig 2. Result shown was obtained from MathSBML.
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