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BIOMD0000000092 - Fuentes2005_ZymogenActivation

 

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Reference Publication
Publication ID: 15634334
Fuentes ME, Varón R, García-Moreno M, Valero E.
Kinetics of intra- and intermolecular zymogen activation with formation of an enzyme-zymogen complex.
FEBS J. 2005 Jan; 272(1): 85-96
Grupo de Modelización en Bioquímica, Departamento de Química-Física, Escuela Politécnica Superior de Albacete, Universidad de Castilla-La Mancha, Albacete, Spain.  [more]
Model
Original Model: JWS logo
Submitter: Nicolas Le Novère
Submission ID: MODEL6623597435
Submission Date: 13 Mar 2007 22:09:12 UTC
Last Modification Date: 13 Feb 2014 15:45:09 UTC
Creation Date: 05 Mar 2007 16:37:52 UTC
Encoders:  Jacky L Snoep
   Harish Dharuri
set #1
bqbiol:is Gene Ontology zymogen activation
set #2
bqbiol:occursIn Taxonomy cellular organisms
set #3
bqmodel:isDerivedFrom PubMed 7558
Notes

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SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS
Run this model online at http://jjj.biochem.sun.ac.za
To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online , Bioinformatics, 20:2143-2144

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The model reproduces Fig 1A of the paper. The model was successfully tested on MathSBML.

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2006 The BioModels Team.
For more information see the terms of use .

Model
Publication ID: 15634334 Submission Date: 13 Mar 2007 22:09:12 UTC Last Modification Date: 13 Feb 2014 15:45:09 UTC Creation Date: 05 Mar 2007 16:37:52 UTC
Mathematical expressions
Reactions
Intramolecular autoactivation Intermolecular autoactivation-Complex formation Intermolecular autoactivation-Enzyme release  
Physical entities
Compartments Species
compartment Zymogen Enzyme Peptide
Enzyme-Substrate complex    
Reactions (3)
 
 Intramolecular autoactivation [Zymogen] ↔ [Peptide] + [Enzyme];  
 
 Intermolecular autoactivation-Complex formation [Zymogen] + [Enzyme] ↔ [Enzyme-Substrate complex];  
 
 Intermolecular autoactivation-Enzyme release [Enzyme-Substrate complex] ↔ [Peptide] + 2.0 × [Enzyme];  
 
 compartment Spatial dimensions: 3.0  Compartment size: 1.0
 
 Zymogen
Compartment: compartment
Initial concentration: 2.4E-5
 
   Enzyme
Compartment: compartment
Initial concentration: 0.0
 
   Peptide
Compartment: compartment
Initial concentration: 0.0
 
 Enzyme-Substrate complex
Compartment: compartment
Initial concentration: 0.0
 
Intramolecular autoactivation (1)
 
   k1
Value: 0.0040   (Units: sec_inv)
Constant
 
Intermolecular autoactivation-Complex formation (2)
 
   k21
Value: 1000.0   (Units: M_inv_sec_inv)
Constant
 
   k22
Value: 2.1E-4   (Units: sec_inv)
Constant
 
Intermolecular autoactivation-Enzyme release (1)
 
   k3
Value: 5.4E-4   (Units: sec_inv)
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000092

Curator's comment: (updated: 13 Mar 2007 00:16:30 GMT)

The plots correspond to time profiles depicted in Fig 1 A of the paper. Simulation results obtained from MathSBML.

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