BioModels Database logo

BioModels Database

spacer

BIOMD0000000082 - Thomsen1988_AdenylateCyclase_Inhibition

 

 |   |   |  Send feedback
Reference Publication
Publication ID: 2904647
Thomsen WJ, Jacquez JA, Neubig RR.
Inhibition of adenylate cyclase is mediated by the high affinity conformation of the alpha 2-adrenergic receptor.
Mol. Pharmacol. 1988 Dec; 34(6): 814-822
Department of Pharmacology, University of Michigan, Ann Arbor 48109-0626.  [more]
Model
Original Model: BIOMD0000000082.origin
Submitter: Enuo He
Submission ID: MODEL1166069080
Submission Date: 27 Nov 2006 22:16:10 UTC
Last Modification Date: 13 Feb 2014 15:49:53 UTC
Creation Date: 26 Sep 2006 18:47:38 UTC
Encoders:  Enuo He
set #1
bqmodel:isDerivedFrom PubMed 6277164
PubMed 6248546
set #2
bqbiol:occursIn Taxonomy Homo sapiens
set #3
bqbiol:isVersionOf Gene Ontology negative regulation of adenylate cyclase activity
Gene Ontology heterotrimeric G-protein complex cycle
Notes

This model was created according to the paper Inhibition of Adenylate Cyclase Is Mediated by the High Affinity Conformation of the alpha2-Adrenergic Receptor published in 1988.

The figure4 (steady state curve) in the paper has been simulated having the same plot with Copasi 4.0.19 (development) and roadRunner(online).Because the initial concentration of R and D were not given in the paper ,so we gave it 1e-9 Mol/L and 1e-8 Mol/L respectively.

Pay attention that the simulations of steady state concentration of species in arbitrary units are shown for figure4 and figure6 in the paper.

Model
Publication ID: 2904647 Submission Date: 27 Nov 2006 22:16:10 UTC Last Modification Date: 13 Feb 2014 15:49:53 UTC Creation Date: 26 Sep 2006 18:47:38 UTC
Mathematical expressions
Reactions
Forming DR DR binding with G_GDP produc DRG_GDP GDP releasing GTP binding with DRG
DRG_GTP dissociates(G protein activation) G protein inactivated    
Physical entities
Compartments Species
cell D DR DRG_GDP
DRG GDP DRG_GTP
GTP R G_GDP
G_GTP    
Reactions (6)
 
 Forming DR [D] + [R] ↔ [DR];  
 
 DR binding with G_GDP produc DRG_GDP [DR] + [G_GDP] ↔ [DRG_GDP];  
 
 GDP releasing [DRG_GDP] ↔ [GDP] + [DRG];  
 
 GTP binding with DRG [DRG] + [GTP] ↔ [DRG_GTP];  
 
 DRG_GTP dissociates(G protein activation) [DRG_GTP] → [G_GTP] + [DR];  
 
 G protein inactivated [G_GTP] → [G_GDP];  
 
 cell Spatial dimensions: 3.0  Compartment size: 1.0
 
 D
Compartment: cell
Initial concentration: 1.0E-8
 
 DR
Compartment: cell
Initial concentration: 0.0
 
 DRG_GDP
Compartment: cell
Initial concentration: 0.0
 
 DRG
Compartment: cell
Initial concentration: 0.0
 
 GDP
Compartment: cell
Initial concentration: 0.0
 
 DRG_GTP
Compartment: cell
Initial concentration: 0.0
 
 GTP
Compartment: cell
Initial concentration: 1.0E-5
 
 R
Compartment: cell
Initial concentration: 1.0E-9
 
 G_GDP
Compartment: cell
Initial concentration: 1.0E-9
 
 G_GTP
Compartment: cell
Initial concentration: 0.0
 
Forming DR (2)
 
   k1
Value: 5000000.0
Constant
 
   k7
Value: 0.5
Constant
 
DR binding with G_GDP produc DRG_GDP (2)
 
   k2
Value: 1.0E8
Constant
 
   k8
Value: 0.1
Constant
 
GDP releasing (2)
 
   k3
Value: 0.1
Constant
 
   k9
Value: 100000.0
Constant
 
GTP binding with DRG (2)
 
   k4
Value: 1.0E7
Constant
 
   k10
Value: 0.1
Constant
 
DRG_GTP dissociates(G protein activation) (1)
 
   k5
Value: 0.05
Constant
 
G protein inactivated (1)
 
   k6
Value: 0.1
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000082

Curator's comment: (updated: 27 Nov 2006 16:49:46 GMT)

The figure 4 has been reproduced by Copasi4.0.19(development).

spacer
spacer