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BIOMD0000000079 - Goldbeter2006_weightCycling

 

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Reference Publication
Publication ID: 16595882
Goldbeter A.
A model for the dynamics of human weight cycling.
J. Biosci. 2006 Mar; 31(1): 129-136
Unite de Chronobiologie theorique, Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, Brussels, Belgium. agoldbet@ulb.ac.be  [more]
Model
Original Model: BIOMD0000000079.xml.origin
Submitter: Enuo He
Submission ID: MODEL4644593552
Submission Date: 27 Nov 2006 17:01:16 UTC
Last Modification Date: 05 Jul 2012 14:50:07 UTC
Creation Date: 24 Nov 2006 10:19:23 UTC
Encoders:  Enuo He
set #1
bqbiol:isVersionOf Gene Ontology rhythmic process
bqbiol:occursIn Taxonomy Homo sapiens
set #2
bqbiol:isVersionOf Gene Ontology regulation of multicellular organism growth
Notes

This model is according to the paper of A model for the dynamics of human weight cycling by A. Goldbeter 2006.The figure3 (A) and (B) have been reproduced by Copasi 4.0.19(development) and SBMLodeSolver.The writer of the paper did not specify any units for the metabolites, so the creator of the model did not define the units as well.Both Q and R are normalized to vary between 0 and 1.


To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.


To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 16595882 Submission Date: 27 Nov 2006 17:01:16 UTC Last Modification Date: 05 Jul 2012 14:50:07 UTC Creation Date: 24 Nov 2006 10:19:23 UTC
Mathematical expressions
Reactions
Increase of P Decrease of P Increase of Q Decrease of Q
Increase of R Decrease of R    
Physical entities
Compartments Species
body P Q R
Reactions (6)
 
 Increase of P  → [P];   {Q}
 
 Decrease of P [P] → ;  
 
 Increase of Q  → [Q];  
 
 Decrease of Q [Q] → ;   {R}
 
 Increase of R  → [R];   {P}
 
 Decrease of R [R] → ;  
 
Functions (5)
 
 function_4 lambda(P, V3, R, k3, P*V3*(1-R)/(k3+(1-R)))
 
 function_3 lambda(V2, R, Q, K2, V2*R*Q/(K2+Q))
 
 function_2 lambda(V1, Q, K1, V1*(1-Q)/(K1+(1-Q)))
 
 function_1 lambda(V, substrate, Km, V*substrate/(Km+substrate))
 
 function_0 lambda(a, Q, a*Q)
 
   body Spatial dimensions: 3.0  Compartment size: 1.0
 
 P
Compartment: body
Initial concentration: 0.43
 
 Q
Compartment: body
Initial concentration: 0.8
 
 R
Compartment: body
Initial concentration: 0.55
 
Increase of P (1)
 
   a
Value: 0.1
Constant
 
Decrease of P (2)
 
   V
Value: 0.1
Constant
 
   Km
Value: 0.2
Constant
 
Increase of Q (2)
 
   V1
Value: 1.0
Constant
 
   K1
Value: 0.01
Constant
 
Decrease of Q (2)
 
   V2
Value: 1.5
Constant
 
   K2
Value: 0.01
Constant
 
Increase of R (2)
 
   V3
Value: 6.0
Constant
 
   k3
Value: 0.01
Constant
 
Decrease of R (2)
 
   V
Value: 2.5
Constant
 
   Km
Value: 0.01
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000079

Curator's comment: (updated: 18 Jan 2010 11:37:07 GMT)

Reproduction of figures 3 A and B from the original publication using Copasi 4.5. The units in fig 3 are not correct.

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