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BIOMD0000000077 - Blum2000_LHsecretion_1

 

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Reference Publication
Publication ID: 10662710
Blum JJ, Reed MC, Janovick JA, Conn PM.
A mathematical model quantifying GnRH-induced LH secretion from gonadotropes.
Am. J. Physiol. Endocrinol. Metab. 2000 Feb; 278(2): E263-72
Department of Cell Biology, Duke University Medical Center, Durham 27710, North Carolina, USA. j.blum@cellbio.duke.edu  [more]
Model
Original Model: BIOMD0000000077.xml.origin
Submitter: Enuo He
Submission ID: MODEL3092061764
Submission Date: 21 Nov 2006 10:30:37 UTC
Last Modification Date: 06 Apr 2014 21:48:24 UTC
Creation Date: 09 Nov 2006 17:07:08 UTC
Encoders:  Enuo He
set #1
bqbiol:isPartOf Gene Ontology phospholipase C-activating G-protein coupled receptor signaling pathway
Gene Ontology luteinizing hormone secretion
set #2
bqbiol:isVersionOf Gene Ontology response to gonadotropin-releasing hormone
set #3
bqbiol:hasTaxon Taxonomy cellular organisms
set #4
bqbiol:hasProperty Mathematical Modelling Ontology MAMO_0000046
Notes

A mathematical model quantifying GnRH-induced LH secretion from gonadotropes by Blum et al (2000)

This paper includes three stages, and the model does not include the third stage. Also an event is included which remove the hormone GnRH at time=5min. Figure 1 and Figure 2 of the paper are reproduced, using SBML odeSolver. We choose to encode the model with the concentration of GnRH equal to 1.0nM.

This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.
For more information see the terms of use.
To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

Model
Publication ID: 10662710 Submission Date: 21 Nov 2006 10:30:37 UTC Last Modification Date: 06 Apr 2014 21:48:24 UTC Creation Date: 09 Nov 2006 17:07:08 UTC
Mathematical expressions
Reactions
H binding to R HR forming HRRH G protein react with dimer producing E IP3 converted into inactive metabolites
Production of IP3      
Rules
Assignment Rule (variable: CHO)      
Events
removal of hormone      
Physical entities
Compartments Species
cell H HR R
HRRH E GQ
IP3 CHO  
Global parameters
alpha beta    
Reactions (5)
 
 H binding to R [H] + [R] ↔ [HR];  
 
 HR forming HRRH 2.0 × [HR] ↔ [HRRH];  
 
 G protein react with dimer producing E [HRRH] + [GQ] ↔ [E];  
 
 IP3 converted into inactive metabolites [IP3] → ;  
 
 Production of IP3  → [IP3];   {E}
 
Rules (1)
 
 Assignment Rule (name: CHO) CHO = 0.001*alpha*IP3*(0.3+0.3*beta*time*exp(1-beta*time))/(1+0.001*alpha*IP3)
 
Events (1)
 
 removal of hormone
H = 0
 
 cell Spatial dimensions: 3.0  Compartment size: 1.0
 
 H
Compartment: cell
Initial concentration: 1.0
 
 HR
Compartment: cell
Initial concentration: 0.0
 
 R
Compartment: cell
Initial concentration: 0.01
 
 HRRH
Compartment: cell
Initial concentration: 0.0
 
 E
Compartment: cell
Initial concentration: 0.0
 
 GQ
Compartment: cell
Initial concentration: 0.1
 
 IP3
Compartment: cell
Initial concentration: 0.0
 
  CHO
Compartment: cell
Initial concentration: 0.0
 
Global Parameters (2)
 
   alpha
Value: 2.0   (Units: substance)
Constant
 
   beta
Value: 4.0   (Units: unit for beta)
Constant
 
H binding to R (2)
 
   k1
Value: 2.5
Constant
 
   k2
Value: 5.0
Constant
 
HR forming HRRH (2)
 
   k1
Value: 2500.0
Constant
 
   k2
Value: 5.0
Constant
 
G protein react with dimer producing E (2)
 
   k1
Value: 4000.0
Constant
 
   k2
Value: 200.0
Constant
 
IP3 converted into inactive metabolites (1)
 
   k1
Value: 10.0
Constant
 
Production of IP3 (1)
 
   k
Value: 2.0E7
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000077

Curator's comment: (updated: 20 Jan 2010 17:15:22 GMT)

Figure 1 E from the article reproduced using SBML odeSolver.

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