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BIOMD0000000051 - Chassagnole2002_Carbon_Metabolism

 

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Reference Publication
Publication ID: 17590932
Chassagnole C, Noisommit-Rizzi N, Schmid JW, Mauch K, Reuss M.
Dynamic modeling of the central carbon metabolism of Escherichia coli.
Biotechnol. Bioeng. 2002 Jul; 79(1): 53-73
Institute of Biochemical Engineering, University of Stuttgart, Stuttgart, Germany.  [more]
Model
Original Model: JWS logo
Submitter: Harish Dharuri
Submission ID: MODEL6624119661
Submission Date: 18 Jan 2006 22:51:54 UTC
Last Modification Date: 01 Aug 2012 17:37:58 UTC
Creation Date: 18 Jan 2006 22:51:54 UTC
Encoders:  Jacky L Snoep
   Harish Dharuri
set #1
bqbiol:occursIn Taxonomy Escherichia coli
bqbiol:hasPart Gene Ontology glycolytic process
Gene Ontology pentose-phosphate shunt
Gene Ontology phosphoenolpyruvate-dependent sugar phosphotransferase system
set #2
bqbiol:hasPart KEGG Pathway map00010
KEGG Pathway map00030
Notes

The model reproduces Figures 4,5 and 6 of the publication. The analytical functions for cometabolites Catp, Camp, Cnadph, and Cnadp slightly differ from the equations given in the paper. These changes were made in consultation with Dr. Christophe Chassagnole and are essential for reproducing the figures. The dependency of the rate of change of extracellular glucose concentration on the ratio of biomass concentration to specific weight of biomass (Cx*rPTS/Rhox) is taken into account by appropriately adjusting the stoichiometries of the species involved in the phosphotransferase system (rPTS). The rmax values for the various reactions are obtained from experiments and are not provided in the paper. However, these were personally communicated to the JWS repository. The model has been successfully tested on MathSBML.

SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS
Run this model online at http://jjj.biochem.sun.ac.za
To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online , Bioinformatics, 20:2143-2144


To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.


To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model
Publication ID: 17590932 Submission Date: 18 Jan 2006 22:51:54 UTC Last Modification Date: 01 Aug 2012 17:37:58 UTC Creation Date: 18 Jan 2006 22:51:54 UTC
Mathematical expressions
Reactions
Phosphotransferase system Glucose-6-phosphate isomerase Phosphoglucomutase Glucose-6-phosphate dehydrogenase
Phosphofructokinase Transaldolase Transketolase a Transketolase b
Mureine synthesis Aldolase Glyceraldehyde-3-phosphate dehydrogenase Triosephosphate isomerase
Tryptophan synthesis Glycerol-3-phosphate dehydrogenase Phosphoglycerate kinase Serine synthesis
Phosphoglycerate mutase Enolase Pyruvate kinase PEP carboxylase
Synthesis 1 Synthesis 2 DAHP synthesis Pyruvate dehydrogenase
Methionine synthesis 6-Phosphogluconate dehydrogenase Ribose-phosphate isomerase Ribulose-phosphate epimerase
Ribose phosphate pyrophosphokinase Glucose-1-phosphate adenyltransferase G6P degradation F6P degradation
FDP degradation GAP degradation DHAP degradation PGP degradation
PG3 degradation PG2 degradation PEP degradation Ribu5P dilution
Rib5P dilution XYL5P dilution SED7P dilution Pyruvate dilution
PG dilution E4P dilution GLP dilution Extracellular glucose kinetics
Rules
Assignment Rule (variable: catp) Assignment Rule (variable: cadp) Assignment Rule (variable: camp) Assignment Rule (variable: cnadph)
Assignment Rule (variable: cnadp) Assignment Rule (variable: cnadh) Assignment Rule (variable: cnad)  
Physical entities
Compartments Species
extracellular Extracellular Glucose    
cytosol Phosphoenol pyruvate Glucose-6-Phosphate Pyruvate
Fructose-6-Phosphate Glucose-1-Phosphate 6-Phosphogluconate
Fructose-1,6-bisphosphate sedoheptulose-7-phosphate Glyceraldehyde-3-Phosphate
Erythrose-4-phosphate Xylulose-5-phosphate Ribose-5-phosphate
Dihydroxyacetonephosphate 1,3-diphosphosphoglycerate 3-Phosphoglycerate
2-Phosphoglycerate Ribulose-5-phosphate  
Global parameters
catp cadp camp cnadp
cnadph cnad cnadh  
Reactions (48)
 
 Phosphotransferase system [Extracellular Glucose] + 65.0 × [Phosphoenol pyruvate] ↔ 65.0 × [Glucose-6-Phosphate] + 65.0 × [Pyruvate];  
 
 Glucose-6-phosphate isomerase [Glucose-6-Phosphate] ↔ [Fructose-6-Phosphate];   {6-Phosphogluconate}
 
 Phosphoglucomutase [Glucose-6-Phosphate] ↔ [Glucose-1-Phosphate];  
 
 Glucose-6-phosphate dehydrogenase [Glucose-6-Phosphate] ↔ [6-Phosphogluconate];  
 
 Phosphofructokinase [Fructose-6-Phosphate] ↔ [Fructose-1,6-bisphosphate];   {Phosphoenol pyruvate}
 
 Transaldolase [Glyceraldehyde-3-Phosphate] + [sedoheptulose-7-phosphate] ↔ [Fructose-6-Phosphate] + [Erythrose-4-phosphate];  
 
 Transketolase a [Ribose-5-phosphate] + [Xylulose-5-phosphate] ↔ [Glyceraldehyde-3-Phosphate] + [sedoheptulose-7-phosphate];  
 
 Transketolase b [Erythrose-4-phosphate] + [Xylulose-5-phosphate] ↔ [Glyceraldehyde-3-Phosphate] + [Fructose-6-Phosphate];  
 
 Mureine synthesis 2.0 × [Fructose-6-Phosphate] ↔ ;  
 
 Aldolase [Fructose-1,6-bisphosphate] ↔ [Dihydroxyacetonephosphate] + [Glyceraldehyde-3-Phosphate];  
 
 Glyceraldehyde-3-phosphate dehydrogenase [Glyceraldehyde-3-Phosphate] ↔ [1,3-diphosphosphoglycerate];  
 
 Triosephosphate isomerase [Dihydroxyacetonephosphate] ↔ [Glyceraldehyde-3-Phosphate];  
 
 Tryptophan synthesis  ↔ [Pyruvate] + [Glyceraldehyde-3-Phosphate];  
 
 Glycerol-3-phosphate dehydrogenase [Dihydroxyacetonephosphate] ↔ ;  
 
 Phosphoglycerate kinase [1,3-diphosphosphoglycerate] ↔ [3-Phosphoglycerate];  
 
 Serine synthesis [3-Phosphoglycerate] ↔ ;  
 
 Phosphoglycerate mutase [3-Phosphoglycerate] ↔ [2-Phosphoglycerate];  
 
 Enolase [2-Phosphoglycerate] ↔ [Phosphoenol pyruvate];  
 
 Pyruvate kinase [Phosphoenol pyruvate] ↔ [Pyruvate];   {Fructose-1,6-bisphosphate}
 
 PEP carboxylase [Phosphoenol pyruvate] ↔ ;   {Fructose-1,6-bisphosphate}
 
 Synthesis 1 [Phosphoenol pyruvate] ↔ ;  
 
 Synthesis 2 [Pyruvate] ↔ ;  
 
 DAHP synthesis [Erythrose-4-phosphate] + [Phosphoenol pyruvate] ↔ ;  
 
 Pyruvate dehydrogenase [Pyruvate] ↔ ;  
 
 Methionine synthesis  ↔ [Pyruvate];  
 
 6-Phosphogluconate dehydrogenase [6-Phosphogluconate] ↔ [Ribulose-5-phosphate];  
 
 Ribose-phosphate isomerase [Ribulose-5-phosphate] ↔ [Ribose-5-phosphate];  
 
 Ribulose-phosphate epimerase [Ribulose-5-phosphate] ↔ [Xylulose-5-phosphate];  
 
 Ribose phosphate pyrophosphokinase [Ribose-5-phosphate] ↔ ;  
 
 Glucose-1-phosphate adenyltransferase [Glucose-1-Phosphate] ↔ ;   {Fructose-1,6-bisphosphate}
 
 G6P degradation [Glucose-6-Phosphate] ↔ ;  
 
 F6P degradation [Fructose-6-Phosphate] ↔ ;  
 
 FDP degradation [Fructose-1,6-bisphosphate] ↔ ;  
 
 GAP degradation [Glyceraldehyde-3-Phosphate] ↔ ;  
 
 DHAP degradation [Dihydroxyacetonephosphate] ↔ ;  
 
 PGP degradation [1,3-diphosphosphoglycerate] ↔ ;  
 
 PG3 degradation [3-Phosphoglycerate] ↔ ;  
 
 PG2 degradation [2-Phosphoglycerate] ↔ ;  
 
 PEP degradation [Phosphoenol pyruvate] ↔ ;  
 
 Ribu5P dilution [Ribulose-5-phosphate] ↔ ;  
 
 Rib5P dilution [Ribose-5-phosphate] ↔ ;  
 
 XYL5P dilution [Xylulose-5-phosphate] ↔ ;  
 
 SED7P dilution [sedoheptulose-7-phosphate] ↔ ;  
 
 Pyruvate dilution [Pyruvate] ↔ ;  
 
 PG dilution [6-Phosphogluconate] ↔ ;  
 
 E4P dilution [Erythrose-4-phosphate] ↔ ;  
 
 GLP dilution [Glucose-1-Phosphate] ↔ ;  
 
 Extracellular glucose kinetics  ↔ [Extracellular Glucose];  
 
Rules (7)
 
 Assignment Rule (name: catp) catp = 4.27-4.163*t/(0.657+1.43*t+0.0364*t^2)
 
 Assignment Rule (name: cadp) cadp = 0.582+1.73*2.731^((-0.15)*t)*(0.12*t+0.000214*t^3)
 
 Assignment Rule (name: camp) camp = 0.123+7.25*t/(7.25+1.47*t+0.17*t^2)+1.073/(1.29+8.05*t)
 
 Assignment Rule (name: cnadph) cnadph = 0.062+0.332*2.718^((-0.464)*t)*(0.0166*t^1.58+0.000166*t^4.73+0.1312*10^(-9)*t^7.89+0.1362*10^(-12)*t^11+0.1233*10^(-15)*t^14.2)
 
 Assignment Rule (name: cnadp) cnadp = 0.159-0.00554*t/(2.8-0.271*t+0.01*t^2)+0.182/(4.82+0.526*t)
 
 Assignment Rule (name: cnadh) cnadh = 0.0934+0.00111*2.371^((-0.123)*t)*(0.844*t+0.104*t^3)
 
 Assignment Rule (name: cnad) cnad = 1.314+1.314*2.73^((-0.0435)*t-0.342)-(t+7.871)*2.73^((-0.0218)*t-0.171)/(8.481+t)
 
  Spatial dimensions: 3.0  Compartment size: 1.0
 
 Extracellular Glucose
Compartment: extracellular
Initial concentration: 2.0
 
  Spatial dimensions: 3.0  Compartment size: 1.0
 
 Phosphoenol pyruvate
Compartment: cytosol
Initial concentration: 2.67
 
 Glucose-6-Phosphate
Compartment: cytosol
Initial concentration: 3.48
 
 Pyruvate
Compartment: cytosol
Initial concentration: 2.67
 
 Fructose-6-Phosphate
Compartment: cytosol
Initial concentration: 0.6
 
 Glucose-1-Phosphate
Compartment: cytosol
Initial concentration: 0.653
 
 6-Phosphogluconate
Compartment: cytosol
Initial concentration: 0.808
 
 Fructose-1,6-bisphosphate
Compartment: cytosol
Initial concentration: 0.272
 
 sedoheptulose-7-phosphate
Compartment: cytosol
Initial concentration: 0.276
 
 Glyceraldehyde-3-Phosphate
Compartment: cytosol
Initial concentration: 0.218
 
 Erythrose-4-phosphate
Compartment: cytosol
Initial concentration: 0.098
 
 Xylulose-5-phosphate
Compartment: cytosol
Initial concentration: 0.138
 
 Ribose-5-phosphate
Compartment: cytosol
Initial concentration: 0.398
 
 Dihydroxyacetonephosphate
Compartment: cytosol
Initial concentration: 0.167
 
 1,3-diphosphosphoglycerate
Compartment: cytosol
Initial concentration: 0.0080
 
 3-Phosphoglycerate
Compartment: cytosol
Initial concentration: 2.13
 
 2-Phosphoglycerate
Compartment: cytosol
Initial concentration: 0.399
 
 Ribulose-5-phosphate
Compartment: cytosol
Initial concentration: 0.111
 
Global Parameters (7)
 
   catp
Value: 4.27   (Units: milli Molar)
 
   cadp
Value: 0.595   (Units: milli Molar)
 
   camp
Value: 0.955   (Units: milli Molar)
 
   cnadp
Value: 0.195   (Units: milli Molar)
 
   cnadph
Value: 0.062   (Units: milli Molar)
 
   cnad
Value: 1.47   (Units: milli Molar)
 
   cnadh
Value: 0.1   (Units: milli Molar)
 
Phosphotransferase system (6)
 
   rmaxPTS
Value: 7829.78   (Units: mM per second)
Constant
 
   KPTSa1
Value: 3082.3   (Units: milli Molar)
Constant
 
   KPTSa2
Value: 0.01   (Units: milli Molar)
Constant
 
   KPTSa3
Value: 245.3   (Units: dimensionless)
Constant
 
   nPTSg6p
Value: 3.66   (Units: dimensionless)
Constant
 
   KPTSg6p
Value: 2.15   (Units: milli Molar)
Constant
 
Glucose-6-phosphate isomerase (6)
 
   rmaxPGI
Value: 650.9878687   (Units: mM per second)
Constant
 
   KPGIeq
Value: 0.1725   (Units: dimensionless)
Constant
 
   KPGIg6p
Value: 2.9   (Units: milli Molar)
Constant
 
   KPGIf6p
Value: 0.266   (Units: milli Molar)
Constant
 
   KPGIf6ppginh
Value: 0.2   (Units: milli Molar)
Constant
 
   KPGIg6ppginh
Value: 0.2   (Units: milli Molar)
Constant
 
Phosphoglucomutase (4)
 
   rmaxPGM
Value: 0.8398242773   (Units: mM per second)
Constant
 
   KPGMeq
Value: 0.196   (Units: dimensionless)
Constant
 
   KPGMg6p
Value: 1.038   (Units: milli Molar)
Constant
 
   KPGMg1p
Value: 0.0136   (Units: milli Molar)
Constant
 
Glucose-6-phosphate dehydrogenase (5)
 
   rmaxG6PDH
Value: 1.380196955   (Units: mM per second)
Constant
 
   KG6PDHg6p
Value: 14.4   (Units: milli Molar)
Constant
 
   KG6PDHnadphg6pinh
Value: 6.43   (Units: milli Molar)
Constant
 
   KG6PDHnadp
Value: 0.0246   (Units: milli Molar)
Constant
 
   KG6PDHnadphnadpinh
Value: 0.01   (Units: milli Molar)
Constant
 
Phosphofructokinase (11)
 
   rmaxPFK
Value: 1840.584747   (Units: mM per second)
Constant
 
   KPFKatps
Value: 0.123   (Units: milli Molar)
Constant
 
   KPFKadpc
Value: 4.14   (Units: milli Molar)
Constant
 
   KPFKf6ps
Value: 0.325   (Units: milli Molar)
Constant
 
   KPFKpep
Value: 3.26   (Units: milli Molar)
Constant
 
   KPFKadpb
Value: 3.89   (Units: milli Molar)
Constant
 
   KPFKampb
Value: 3.2   (Units: milli Molar)
Constant
 
   KPFKadpa
Value: 128.0   (Units: milli Molar)
Constant
 
   KPFKampa
Value: 19.1   (Units: milli Molar)
Constant
 
   LPFK
Value: 5629067.0   (Units: dimensionless)
Constant
 
   nPFK
Value: 11.1   (Units: dimensionless)
Constant
 
Transaldolase (2)
 
   rmaxTA
Value: 10.87164108   (Units: per mM per second)
Constant
 
   KTAeq
Value: 1.05   (Units: dimensionless)
Constant
 
Transketolase a (2)
 
   rmaxTKa
Value: 9.473384783   (Units: per mM per second)
Constant
 
   KTKaeq
Value: 1.2   (Units: dimensionless)
Constant
 
Transketolase b (2)
 
   rmaxTKb
Value: 86.55855855   (Units: per mM per second)
Constant
 
   KTKbeq
Value: 10.0   (Units: dimensionless)
Constant
 
Mureine synthesis (1)
 
   rmaxMurSynth
Value: 4.3711E-4   (Units: mM per second)
Constant
 
Aldolase (7)
 
   rmaxALDO
Value: 17.41464425   (Units: mM per second)
Constant
 
   kALDOeq
Value: 0.144   (Units: milli Molar)
Constant
 
   kALDOfdp
Value: 1.75   (Units: milli Molar)
Constant
 
   kALDOgap
Value: 0.088   (Units: milli Molar)
Constant
 
   VALDOblf
Value: 2.0   (Units: dimensionless)
Constant
 
   kALDOdhap
Value: 0.088   (Units: milli Molar)
Constant
 
   kALDOgapinh
Value: 0.6   (Units: milli Molar)
Constant
 
Glyceraldehyde-3-phosphate dehydrogenase (6)
 
   rmaxGAPDH
Value: 921.5942861   (Units: mM per second)
Constant
 
   KGAPDHeq
Value: 0.63   (Units: dimensionless)
Constant
 
   KGAPDHgap
Value: 0.683   (Units: milli Molar)
Constant
 
   KGAPDHpgp
Value: 1.04E-5   (Units: milli Molar)
Constant
 
   KGAPDHnad
Value: 0.252   (Units: milli Molar)
Constant
 
   KGAPDHnadh
Value: 1.09   (Units: milli Molar)
Constant
 
Triosephosphate isomerase (4)
 
   rmaxTIS
Value: 68.67474392   (Units: mM per second)
Constant
 
   kTISeq
Value: 1.39   (Units: dimensionless)
Constant
 
   kTISdhap
Value: 2.8   (Units: milli Molar)
Constant
 
   kTISgap
Value: 0.3   (Units: milli Molar)
Constant
 
Tryptophan synthesis (1)
 
   rmaxTrpSynth
Value: 0.001037   (Units: mM per second)
Constant
 
Glycerol-3-phosphate dehydrogenase (2)
 
   rmaxG3PDH
Value: 0.01162042696   (Units: mM per second)
Constant
 
   KG3PDHdhap
Value: 1.0   (Units: milli Molar)
Constant
 
Phosphoglycerate kinase (6)
 
   rmaxPGK
Value: 3021.773771   (Units: mM per second)
Constant
 
   KPGKeq
Value: 1934.4   (Units: dimensionless)
Constant
 
   KPGKadp
Value: 0.185   (Units: milli Molar)
Constant
 
   KPGKatp
Value: 0.653   (Units: milli Molar)
Constant
 
   KPGKpgp
Value: 0.0468   (Units: milli Molar)
Constant
 
   KPGKpg3
Value: 0.473   (Units: milli Molar)
Constant
 
Serine synthesis (2)
 
   rmaxSerSynth
Value: 0.025712107   (Units: mM per second)
Constant
 
   KSerSynthpg3
Value: 1.0   (Units: milli Molar)
Constant
 
Phosphoglycerate mutase (4)
 
   rmaxPGluMu
Value: 89.04965407   (Units: mM per second)
Constant
 
   KPGluMueq
Value: 0.188   (Units: dimensionless)
Constant
 
   KPGluMupg3
Value: 0.2   (Units: milli Molar)
Constant
 
   KPGluMupg2
Value: 0.369   (Units: milli Molar)
Constant
 
Enolase (4)
 
   rmaxENO
Value: 330.4476151   (Units: mM per second)
Constant
 
   KENOeq
Value: 6.73   (Units: milli Molar)
Constant
 
   KENOpg2
Value: 0.1   (Units: milli Molar)
Constant
 
   KENOpep
Value: 0.135   (Units: milli Molar)
Constant
 
Pyruvate kinase (8)
 
   rmaxPK
Value: 0.06113150238   (Units: mM per second)
Constant
 
   KPKpep
Value: 0.31   (Units: milli Molar)
Constant
 
   nPK
Value: 4.0   (Units: dimensionless)
Constant
 
   LPK
Value: 1000.0   (Units: dimensionless)
Constant
 
   KPKatp
Value: 22.5   (Units: milli Molar)
Constant
 
   KPKfdp
Value: 0.19   (Units: milli Molar)
Constant
 
   KPKamp
Value: 0.2   (Units: milli Molar)
Constant
 
   KPKadp
Value: 0.26   (Units: milli Molar)
Constant
 
PEP carboxylase (4)
 
   rmaxpepCxylase
Value: 0.1070205858   (Units: mM per second)
Constant
 
   KpepCxylasefdp
Value: 0.7   (Units: milli Molar)
Constant
 
   npepCxylasefdp
Value: 4.21   (Units: dimensionless)
Constant
 
   KpepCxylasepep
Value: 4.07   (Units: milli Molar)
Constant
 
Synthesis 1 (2)
 
   rmaxSynth1
Value: 0.01953897003   (Units: mM per second)
Constant
 
   KSynth1pep
Value: 1.0   (Units: milli Molar)
Constant
 
Synthesis 2 (2)
 
   rmaxSynth2
Value: 0.07361855055   (Units: mM per second)
Constant
 
   KSynth2pyr
Value: 1.0   (Units: milli Molar)
Constant
 
DAHP synthesis (5)
 
   rmaxDAHPS
Value: 0.1079531227   (Units: mM per second)
Constant
 
   nDAHPSe4p
Value: 2.6   (Units: dimensionless)
Constant
 
   nDAHPSpep
Value: 2.2   (Units: dimensionless)
Constant
 
   KDAHPSe4p
Value: 0.035   (Units: milli Molar)
Constant
 
   KDAHPSpep
Value: 0.0053   (Units: milli Molar)
Constant
 
Pyruvate dehydrogenase (3)
 
   rmaxPDH
Value: 6.059531017   (Units: mM per second)
Constant
 
   nPDH
Value: 3.68   (Units: dimensionless)
Constant
 
   KPDHpyr
Value: 1159.0   (Units: milli Molar)
Constant
 
Methionine synthesis (1)
 
   rmaxMetSynth
Value: 0.0022627   (Units: mM per second)
Constant
 
6-Phosphogluconate dehydrogenase (5)
 
   rmaxPGDH
Value: 16.23235977   (Units: mM per second)
Constant
 
   KPGDHpg
Value: 37.5   (Units: milli Molar)
Constant
 
   KPGDHnadp
Value: 0.0506   (Units: milli Molar)
Constant
 
   KPGDHnadphinh
Value: 0.0138   (Units: milli Molar)
Constant
 
   KPGDHatpinh
Value: 208.0   (Units: milli Molar)
Constant
 
Ribose-phosphate isomerase (2)
 
   rmaxR5PI
Value: 4.83841193   (Units: second inverse)
Constant
 
   KR5PIeq
Value: 4.0   (Units: dimensionless)
Constant
 
Ribulose-phosphate epimerase (2)
 
   rmaxRu5P
Value: 6.739029475   (Units: second inverse)
Constant
 
   KRu5Peq
Value: 1.4   (Units: dimensionless)
Constant
 
Ribose phosphate pyrophosphokinase (2)
 
   rmaxRPPK
Value: 0.01290045226   (Units: mM per second)
Constant
 
   KRPPKrib5p
Value: 0.1   (Units: milli Molar)
Constant
 
Glucose-1-phosphate adenyltransferase (5)
 
   rmaxG1PAT
Value: 0.007525458026   (Units: mM per second)
Constant
 
   KG1PATfdp
Value: 0.119   (Units: milli Molar)
Constant
 
   nG1PATfdp
Value: 1.2   (Units: milli Molar)
Constant
 
   KG1PATatp
Value: 4.42   (Units: milli Molar)
Constant
 
   KG1PATg1p
Value: 3.2   (Units: milli Molar)
Constant
 
G6P degradation (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
F6P degradation (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
FDP degradation (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
GAP degradation (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
DHAP degradation (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
PGP degradation (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
PG3 degradation (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
PG2 degradation (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
PEP degradation (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
Ribu5P dilution (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
Rib5P dilution (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
XYL5P dilution (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
SED7P dilution (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
Pyruvate dilution (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
PG dilution (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
E4P dilution (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
GLP dilution (1)
 
   mu
Value: 2.78E-5   (Units: second inverse)
Constant
 
Extracellular glucose kinetics (2)
 
   Dil
Value: 2.78E-5   (Units: second inverse)
Constant
 
   cfeed
Value: 110.96   (Units: milli Molar)
Constant
 
Representative curation result(s)
Representative curation result(s) of BIOMD0000000051

Curator's comment: (updated: 15 Dec 2006 13:38:28 GMT)

The model reproduces Fig 4, 5 and 6 of the publication. Simulation obtained from MathSBML.

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