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BIOMD0000000014 - Levchenko2000_MAPK_Scaffold

 

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Reference Publication
Publication ID: 10823939
Levchenko A, Bruck J, Sternberg PW.
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties.
Proc. Natl. Acad. Sci. U.S.A. 2000 May; 97(11): 5818-5823
Division of Engineering and Applied Science and Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA. andre@paradise.caltech.edu  [more]
Model
Original Model: BIOMD0000000014.xml.origin
Submitter: Nicolas Le Novère
Submission ID: MODEL6616691524
Submission Date: 13 Sep 2005 13:07:14 UTC
Last Modification Date: 03 Jun 2013 13:36:47 UTC
Creation Date: 25 Feb 2005 23:43:21 UTC
Encoders:  Bruce Shapiro
set #1
bqmodel:isDerivedFrom BioModels Database Levchenko2000_MAPK_noScaffold
set #2
bqbiol:occursIn Taxonomy Xenopus laevis
set #3
bqbiol:isHomologTo Reactome REACT_634
set #4
bqbiol:isVersionOf Gene Ontology MAPK cascade
Gene Ontology MAP-kinase scaffold activity
Notes

MAPK cascade on a scaffold

Citation
Levchenko, A., Bruck, J., Sternberg, P.W. (2000) .Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc. Natl. Acad. Sci. USA 97(11):5818-5823. http://www.pnas.org/cgi/content/abstract/97/11/5818
Description
This model describes a basic 3-stage Mitogen Activated Protein Kinase (MAPK). Kinases in solution are written as K[3,J], K[2,J], K[1,J] for MAPKKK, MAPKK, and MAPK, respectively, J indicates the phosphorylation level, J=0,1 for K3 and J=0,1,2 for K2 and K1. Scaffolds have three slots, for MAPK, MAPKK, and MAPKKK, respectively. Bound and free scaffold are denoted as S[i,j,k], where i, j, and k indicate the binding of K[1,i], K[2,j] and K[3,k] in their respective slots. Here i,j=-1,0,1,or,2 and k=-1,0,or,1. A value of -1 means the slot is empty, 0 means the unphorphorylated kinase is bound, 1 means the singly phosphorylated kinase is bound, and 2 means the doubly phosphorylated kinase is bound. Thus S[1,-1,2] is a scaffold with K[3,1] bound in the first slot and K[1,2] in the third slot, while the second slot is empty.Note: Indices X[I,J,K] are translated into the unindexed variable X_I_J_K and so forth in the SBML. Negative indices are translated as mI, etc, thus S[1,-1,2] becomes S_1_m1_2.
Rate constant       Reaction
a10 = 5. MAPKP + K[1, 2] -> K_MAPKP[1, 2]
a1 = 1. RAFK + K[3, 0] -> K_RAFK[3, 0]
a2 = 0.5 RAFP + K[3, 1] -> K_RAFP[3, 1]
a3 = 3.3 K[2, 0] + K[3, 1] -> K_K[2, 0, 3,  1]
a4 = 10. MEKP + K[2, 1] -> K_MEKP[2, 1]
a5 = 3.3 K[2, 1] + K[3, 1] -> K_K[2, 1, 3,  1]
a6 = 10. MEKP + K[2, 2] -> K_MEKP[2, 2]
a7 = 20. K[1, 0] + K[2, 2] -> K_K[1, 0, 2,  2]
a8 = 5. MAPKP + K[1, 1] -> K_MAPKP[1, 1]
a9 = 20. K[1, 1] + K[2, 2] -> K_K[1, 1, 2,  2]
d10 = 0.4 K_MAPKP[1, 2] -> MAPKP + K[1, 2]
d1 = 0.4 K_RAFK[3, 0] -> RAFK + K[3, 0]
d1a = 0 S_RAFK[0, 0, 0] -> RAFK + S[0, 0, 0]
d1a = 0 S_RAFK[0, -1, 0] -> RAFK + S[0, -1,  0]
d1a = 0 S_RAFK[0, 1, 0] -> RAFK + S[0, 1, 0]
d1a = 0 S_RAFK[0, 2, 0] -> RAFK + S[0, 2, 0]
d1a = 0 S_RAFK[-1, 0, 0] -> RAFK + S[-1, 0,  0]
d1a = 0 S_RAFK[1, 0, 0] -> RAFK + S[1, 0, 0]
d1a = 0 S_RAFK[-1, -1, 0] -> RAFK + S[-1, -1,  0]
d1a = 0 S_RAFK[-1, 1, 0] -> RAFK + S[-1, 1,  0]
d1a = 0 S_RAFK[1, -1, 0] -> RAFK + S[1, -1,  0]
d1a = 0 S_RAFK[1, 1, 0] -> RAFK + S[1, 1, 0]
d1a = 0 S_RAFK[-1, 2, 0] -> RAFK + S[-1, 2,  0]
d1a = 0 S_RAFK[1, 2, 0] -> RAFK + S[1, 2, 0]
d1a = 0 S_RAFK[2, 0, 0] -> RAFK + S[2, 0, 0]
d1a = 0 S_RAFK[2, -1, 0] -> RAFK + S[2, -1,  0]
d1a = 0 S_RAFK[2, 1, 0] -> RAFK + S[2, 1, 0]
d1a = 0 S_RAFK[2, 2, 0] -> RAFK + S[2, 2, 0]
d2 = 0.5 K_RAFP[3, 1] -> RAFP + K[3, 1]
d3 = 0.42 K_K[2, 0, 3, 1] -> K[2, 0] + K[3,  1]
d4 = 0.8 K_MEKP[2, 1] -> MEKP + K[2, 1]
d5 = 0.4 K_K[2, 1, 3, 1] -> K[2, 1] + K[3,  1]
d6 = 0.8 K_MEKP[2, 2] -> MEKP + K[2, 2]
d7 = 0.6 K_K[1, 0, 2, 2] -> K[1, 0] + K[2,  2]
d8 = 0.4 K_MAPKP[1, 1] -> MAPKP + K[1, 1]
d9 = 0.6 K_K[1, 1, 2, 2] -> K[1, 1] + K[2,  2]
k10 = 0.1 K_MAPKP[1, 2] -> MAPKP + K[1, 1]
k1 = 0.1 K_RAFK[3, 0] -> RAFK + K[3, 1]
k1 = 0.1 S_RAFK[0, 0, 0] -> RAFK + S[0, 0, 1]
k1 = 0.1 S_RAFK[0, -1, 0] -> RAFK + S[0, -1,  1]
k1 = 0.1 S_RAFK[0, 1, 0] -> RAFK + S[0, 1, 1]
k1 = 0.1 S_RAFK[0, 2, 0] -> RAFK + S[0, 2, 1]
k1 = 0.1 S_RAFK[-1, 0, 0] -> RAFK + S[-1, 0,  1]
k1 = 0.1 S_RAFK[1, 0, 0] -> RAFK + S[1, 0, 1]
k1 = 0.1 S_RAFK[-1, -1, 0] -> RAFK + S[-1, -1,  1]
k1 = 0.1 S_RAFK[-1, 1, 0] -> RAFK + S[-1, 1,  1]
k1 = 0.1 S_RAFK[1, -1, 0] -> RAFK + S[1, -1,  1]
k1 = 0.1 S_RAFK[1, 1, 0] -> RAFK + S[1, 1, 1]
k1 = 0.1 S_RAFK[-1, 2, 0] -> RAFK + S[-1, 2,  1]
k1 = 0.1 S_RAFK[1, 2, 0] -> RAFK + S[1, 2, 1]
k1 = 0.1 S_RAFK[2, 0, 0] -> RAFK + S[2, 0, 1]
k1 = 0.1 S_RAFK[2, -1, 0] -> RAFK + S[2, -1,  1]
k1 = 0.1 S_RAFK[2, 1, 0] -> RAFK + S[2, 1, 1]
k1 = 0.1 S_RAFK[2, 2, 0] -> RAFK + S[2, 2, 1]
k1a = 100 RAFK + S[0, 0, 0] -> S_RAFK[0, 0, 0]
k1a = 100 RAFK + S[0, -1, 0] -> S_RAFK[0, -1,  0]
k1a = 100 RAFK + S[0, 1, 0] -> S_RAFK[0, 1, 0]
k1a = 100 RAFK + S[0, 2, 0] -> S_RAFK[0, 2, 0]
k1a = 100 RAFK + S[-1, 0, 0] -> S_RAFK[-1, 0,  0]
k1a = 100 RAFK + S[1, 0, 0] -> S_RAFK[1, 0, 0]
k1a = 100 RAFK + S[-1, -1, 0] -> S_RAFK[-1, -1,  0]
k1a = 100 RAFK + S[-1, 1, 0] -> S_RAFK[-1, 1,  0]
k1a = 100 RAFK + S[1, -1, 0] -> S_RAFK[1, -1,  0]
k1a = 100 RAFK + S[1, 1, 0] -> S_RAFK[1, 1, 0]
k1a = 100 RAFK + S[-1, 2, 0] -> S_RAFK[-1, 2,  0]
k1a = 100 RAFK + S[1, 2, 0] -> S_RAFK[1, 2, 0]
k1a = 100 RAFK + S[2, 0, 0] -> S_RAFK[2, 0, 0]
k1a = 100 RAFK + S[2, -1, 0] -> S_RAFK[2, -1,  0]
k1a = 100 RAFK + S[2, 1, 0] -> S_RAFK[2, 1, 0]
k1a = 100 RAFK + S[2, 2, 0] -> S_RAFK[2, 2, 0]
k2 = 0.1 K_RAFP[3, 1] -> RAFP + K[3, 0]
k3 = 0.1 K_K[2, 0, 3, 1] -> K[2, 1] + K[3,  1]
k3 = 0.1 S[0, 0, 1] -> S[0, 1, 1]
k3 = 0.1 S[-1, 0, 1] -> S[-1, 1, 1]
k3 = 0.1 S[1, 0, 1] -> S[1, 1, 1]
k3 = 0.1 S[2, 0, 1] -> S[2, 1, 1]
k4 = 0.1 K_MEKP[2, 1] -> MEKP + K[2, 0]
k5 = 0.1 K_K[2, 1, 3, 1] -> K[2, 2] + K[3,  1]
k5a = 0.1 S[0, 1, 1] -> S[0, 2, 1]
k5a = 0.1 S[-1, 1, 1] -> S[-1, 2, 1]
k5a = 0.1 S[1, 1, 1] -> S[1, 2, 1]
k5a = 0.1 S[2, 1, 1] -> S[2, 2, 1]
k6 = 0.1 K_MEKP[2, 2] -> MEKP + K[2, 1]
k7 = 0.1 K_K[1, 0, 2, 2] -> K[1, 1] + K[2,  2]
k7 = 0.1 S[0, 2, 0] -> S[1, 2, 0]
k7 = 0.1 S[0, 2, -1] -> S[1, 2, -1]
k7 = 0.1 S[0, 2, 1] -> S[1, 2, 1]
k8 = 0.1 K_MAPKP[1, 1] -> MAPKP + K[1, 0]
k9 = 0.1 K_K[1, 1, 2, 2] -> K[1, 2] + K[2,  2]
k9a = 0.1 S[1, 2, 0] -> S[2, 2, 0]
k9a = 0.1 S[1, 2, -1] -> S[2, 2, -1]
k9a = 0.1 S[1, 2, 1] -> S[2, 2, 1]
koff = 0.5 S[0, 0, 0] -> K[1, 0] + S[-1, 0,  0]
koff = 0.5 S[0, 0, 0] -> K[2, 0] + S[0, -1,  0]
koff = 0.5 S[0, 0, 0] -> K[3, 0] + S[0, 0,  -1]
koff = 0.5 S[0, 0, -1] -> K[1, 0] + S[-1, 0,  -1]
koff = 0.5 S[0, 0, 1] -> K[1, 0] + S[-1, 0,  1]
koff = 0.5 S[0, 0, -1] -> K[2, 0] + S[0, -1,  -1]
koff = 0.5 S[0, 0, 1] -> K[2, 0] + S[0, -1,  1]
koff = 0.5 S[0, -1, 0] -> K[1, 0] + S[-1, -1,  0]
koff = 0.5 S[0, 1, 0] -> K[1, 0] + S[-1, 1,  0]
koff = 0.5 S[0, -1, 0] -> K[3, 0] + S[0, -1,  -1]
koff = 0.5 S[0, 1, 0] -> K[3, 0] + S[0, 1,  -1]
koff = 0.5 S[0, -1, -1] -> K[1, 0] + S[-1, -1,  -1]
koff = 0.5 S[0, -1, 1] -> K[1, 0] + S[-1, -1,  1]
koff = 0.5 S[0, 1, -1] -> K[1, 0] + S[-1, 1,  -1]
koff = 0.5 S[0, 1, 1] -> K[1, 0] + S[-1, 1,  1]
koff = 0.5 S[0, 2, 0] -> K[1, 0] + S[-1, 2,  0]
koff = 0.5 S[0, 2, 0] -> K[3, 0] + S[0, 2,  -1]
koff = 0.5 S[0, 2, -1] -> K[1, 0] + S[-1, 2,  -1]
koff = 0.5 S[0, 2, 1] -> K[1, 0] + S[-1, 2,  1]
koff = 0.5 S[-1, 0, 0] -> K[2, 0] + S[-1, -1,  0]
koff = 0.5 S[1, 0, 0] -> K[2, 0] + S[1, -1,  0]
koff = 0.5 S[-1, 0, 0] -> K[3, 0] + S[-1, 0,  -1]
koff = 0.5 S[1, 0, 0] -> K[3, 0] + S[1, 0,  -1]
koff = 0.5 S[-1, 0, -1] -> K[2, 0] + S[-1, -1,  -1]
koff = 0.5 S[-1, 0, 1] -> K[2, 0] + S[-1, -1,  1]
koff = 0.5 S[1, 0, -1] -> K[2, 0] + S[1, -1,  -1]
koff = 0.5 S[1, 0, 1] -> K[2, 0] + S[1, -1,  1]
koff = 0.5 S[-1, -1, 0] -> K[3, 0] + S[-1, -1,  -1]
koff = 0.5 S[-1, 1, 0] -> K[3, 0] + S[-1, 1,  -1]
koff = 0.5 S[1, -1, 0] -> K[3, 0] + S[1, -1,  -1]
koff = 0.5 S[1, 1, 0] -> K[3, 0] + S[1, 1,  -1]
koff = 0.5 S[-1, 2, 0] -> K[3, 0] + S[-1, 2,  -1]
koff = 0.5 S[1, 2, 0] -> K[3, 0] + S[1, 2,  -1]
koff = 0.5 S[2, 0, 0] -> K[2, 0] + S[2, -1,  0]
koff = 0.5 S[2, 0, 0] -> K[3, 0] + S[2, 0,  -1]
koff = 0.5 S[2, 0, -1] -> K[2, 0] + S[2, -1,  -1]
koff = 0.5 S[2, 0, 1] -> K[2, 0] + S[2, -1,  1]
koff = 0.5 S[2, -1, 0] -> K[3, 0] + S[2, -1,  -1]
koff = 0.5 S[2, 1, 0] -> K[3, 0] + S[2, 1,  -1]
koff = 0.5 S[2, 2, 0] -> K[3, 0] + S[2, 2,  -1]
kon = 10 K[1, 0] + S[-1, 0, 0] -> S[0, 0,  0]
kon = 10 K[1, 0] + S[-1, 0, -1] -> S[0, 0,  -1]
kon = 10 K[1, 0] + S[-1, 0, 1] -> S[0, 0,  1]
kon = 10 K[1, 0] + S[-1, -1, 0] -> S[0, -1,  0]
kon = 10 K[1, 0] + S[-1, 1, 0] -> S[0, 1,  0]
kon = 10 K[1, 0] + S[-1, -1, -1] -> S[0, -1,  -1]
kon = 10 K[1, 0] + S[-1, -1, 1] -> S[0, -1,  1]
kon = 10 K[1, 0] + S[-1, 1, -1] -> S[0, 1,  -1]
kon = 10 K[1, 0] + S[-1, 1, 1] -> S[0, 1,  1]
kon = 10 K[1, 0] + S[-1, 2, 0] -> S[0, 2,  0]
kon = 10 K[1, 0] + S[-1, 2, -1] -> S[0, 2,  -1]
kon = 10 K[1, 0] + S[-1, 2, 1] -> S[0, 2,  1]
kon = 10 K[2, 0] + S[0, -1, 0] -> S[0, 0,  0]
kon = 10 K[2, 0] + S[0, -1, -1] -> S[0, 0,  -1]
kon = 10 K[2, 0] + S[0, -1, 1] -> S[0, 0,  1]
kon = 10 K[2, 0] + S[-1, -1, 0] -> S[-1, 0,  0]
kon = 10 K[2, 0] + S[1, -1, 0] -> S[1, 0,  0]
kon = 10 K[2, 0] + S[-1, -1, -1] -> S[-1, 0,  -1]
kon = 10 K[2, 0] + S[-1, -1, 1] -> S[-1, 0,  1]
kon = 10 K[2, 0] + S[1, -1, -1] -> S[1, 0,  -1]
kon = 10 K[2, 0] + S[1, -1, 1] -> S[1, 0,  1]
kon = 10 K[2, 0] + S[2, -1, 0] -> S[2, 0,  0]
kon = 10 K[2, 0] + S[2, -1, -1] -> S[2, 0,  -1]
kon = 10 K[2, 0] + S[2, -1, 1] -> S[2, 0,  1]
kon = 10 K[3, 0] + S[0, 0, -1] -> S[0, 0,  0]
kon = 10 K[3, 0] + S[0, -1, -1] -> S[0, -1,  0]
kon = 10 K[3, 0] + S[0, 1, -1] -> S[0, 1,  0]
kon = 10 K[3, 0] + S[0, 2, -1] -> S[0, 2,  0]
kon = 10 K[3, 0] + S[-1, 0, -1] -> S[-1, 0,  0]
kon = 10 K[3, 0] + S[1, 0, -1] -> S[1, 0,  0]
kon = 10 K[3, 0] + S[-1, -1, -1] -> S[-1, -1,  0]
kon = 10 K[3, 0] + S[-1, 1, -1] -> S[-1, 1,  0]
kon = 10 K[3, 0] + S[1, -1, -1] -> S[1, -1,  0]
kon = 10 K[3, 0] + S[1, 1, -1] -> S[1, 1,  0]
kon = 10 K[3, 0] + S[-1, 2, -1] -> S[-1, 2,  0]
kon = 10 K[3, 0] + S[1, 2, -1] -> S[1, 2,  0]
kon = 10 K[3, 0] + S[2, 0, -1] -> S[2, 0,  0]
kon = 10 K[3, 0] + S[2, -1, -1] -> S[2, -1,  0]
kon = 10 K[3, 0] + S[2, 1, -1] -> S[2, 1,  0]
kon = 10 K[3, 0] + S[2, 2, -1] -> S[2, 2,  0]
kpoff = 0.05 S[0, 0, 1] -> K[3, 1] + S[0, 0,  -1]
kpoff = 0.05 S[0, 1, 0] -> K[2, 1] + S[0, -1,  0]
kpoff = 0.05 S[0, 1, -1] -> K[2, 1] + S[0, -1,  -1]
kpoff = 0.05 S[0, 1, 1] -> K[2, 1] + S[0, -1,  1]
kpoff = 0.05 S[0, -1, 1] -> K[3, 1] + S[0, -1,  -1]
kpoff = 0.05 S[0, 1, 1] -> K[3, 1] + S[0, 1,  -1]
kpoff = 0.05 S[0, 2, 0] -> K[2, 2] + S[0, -1,  0]
kpoff = 0.05 S[0, 2, -1] -> K[2, 2] + S[0, -1,  -1]
kpoff = 0.05 S[0, 2, 1] -> K[2, 2] + S[0, -1,  1]
kpoff = 0.05 S[0, 2, 1] -> K[3, 1] + S[0, 2,  -1]
kpoff = 0.05 S[1, 0, 0] -> K[1, 1] + S[-1, 0,  0]
kpoff = 0.05 S[1, 0, -1] -> K[1, 1] + S[-1, 0,  -1]
kpoff = 0.05 S[1, 0, 1] -> K[1, 1] + S[-1, 0,  1]
kpoff = 0.05 S[-1, 0, 1] -> K[3, 1] + S[-1, 0,  -1]
kpoff = 0.05 S[1, 0, 1] -> K[3, 1] + S[1, 0,  -1]
kpoff = 0.05 S[1, -1, 0] -> K[1, 1] + S[-1, -1,  0]
kpoff = 0.05 S[1, 1, 0] -> K[1, 1] + S[-1, 1,  0]
kpoff = 0.05 S[-1, 1, 0] -> K[2, 1] + S[-1, -1,  0]
kpoff = 0.05 S[1, 1, 0] -> K[2, 1] + S[1, -1,  0]
kpoff = 0.05 S[1, -1, -1] -> K[1, 1] + S[-1, -1,  -1]
kpoff = 0.05 S[1, -1, 1] -> K[1, 1] + S[-1, -1,  1]
kpoff = 0.05 S[1, 1, -1] -> K[1, 1] + S[-1, 1,  -1]
kpoff = 0.05 S[1, 1, 1] -> K[1, 1] + S[-1, 1,  1]
kpoff = 0.05 S[-1, 1, -1] -> K[2, 1] + S[-1, -1,  -1]
kpoff = 0.05 S[-1, 1, 1] -> K[2, 1] + S[-1, -1,  1]
kpoff = 0.05 S[1, 1, -1] -> K[2, 1] + S[1, -1,  -1]
kpoff = 0.05 S[1, 1, 1] -> K[2, 1] + S[1, -1,  1]
kpoff = 0.05 S[-1, -1, 1] -> K[3, 1] + S[-1, -1,  -1]
kpoff = 0.05 S[-1, 1, 1] -> K[3, 1] + S[-1, 1,  -1]
kpoff = 0.05 S[1, -1, 1] -> K[3, 1] + S[1, -1,  -1]
kpoff = 0.05 S[1, 1, 1] -> K[3, 1] + S[1, 1,  -1]
kpoff = 0.05 S[1, 2, 0] -> K[1, 1] + S[-1, 2,  0]
kpoff = 0.05 S[-1, 2, 0] -> K[2, 2] + S[-1, -1,  0]
kpoff = 0.05 S[1, 2, 0] -> K[2, 2] + S[1, -1,  0]
kpoff = 0.05 S[1, 2, -1] -> K[1, 1] + S[-1, 2,  -1]
kpoff = 0.05 S[1, 2, 1] -> K[1, 1] + S[-1, 2,  1]
kpoff = 0.05 S[-1, 2, -1] -> K[2, 2] + S[-1, -1,  -1]
kpoff = 0.05 S[-1, 2, 1] -> K[2, 2] + S[-1, -1,  1]
kpoff = 0.05 S[1, 2, -1] -> K[2, 2] + S[1, -1,  -1]
kpoff = 0.05 S[1, 2, 1] -> K[2, 2] + S[1, -1,  1]
kpoff = 0.05 S[-1, 2, 1] -> K[3, 1] + S[-1, 2,  -1]
kpoff = 0.05 S[1, 2, 1] -> K[3, 1] + S[1, 2,  -1]
kpoff = 0.05 S[2, 0, 0] -> K[1, 2] + S[-1, 0,  0]
kpoff = 0.05 S[2, 0, -1] -> K[1, 2] + S[-1, 0,  -1]
kpoff = 0.05 S[2, 0, 1] -> K[1, 2] + S[-1, 0,  1]
kpoff = 0.05 S[2, 0, 1] -> K[3, 1] + S[2, 0,  -1]
kpoff = 0.05 S[2, -1, 0] -> K[1, 2] + S[-1, -1,  0]
kpoff = 0.05 S[2, 1, 0] -> K[1, 2] + S[-1, 1,  0]
kpoff = 0.05 S[2, 1, 0] -> K[2, 1] + S[2, -1,  0]
kpoff = 0.05 S[2, -1, -1] -> K[1, 2] + S[-1, -1,  -1]
kpoff = 0.05 S[2, -1, 1] -> K[1, 2] + S[-1, -1,  1]
kpoff = 0.05 S[2, 1, -1] -> K[1, 2] + S[-1, 1,  -1]
kpoff = 0.05 S[2, 1, 1] -> K[1, 2] + S[-1, 1,  1]
kpoff = 0.05 S[2, 1, -1] -> K[2, 1] + S[2, -1,  -1]
kpoff = 0.05 S[2, 1, 1] -> K[2, 1] + S[2, -1,  1]
kpoff = 0.05 S[2, -1, 1] -> K[3, 1] + S[2, -1,  -1]
kpoff = 0.05 S[2, 1, 1] -> K[3, 1] + S[2, 1,  -1]
kpoff = 0.05 S[2, 2, 0] -> K[1, 2] + S[-1, 2,  0]
kpoff = 0.05 S[2, 2, 0] -> K[2, 2] + S[2, -1,  0]
kpoff = 0.05 S[2, 2, -1] -> K[1, 2] + S[-1, 2,  -1]
kpoff = 0.05 S[2, 2, 1] -> K[1, 2] + S[-1, 2,  1]
kpoff = 0.05 S[2, 2, -1] -> K[2, 2] + S[2, -1,  -1]
kpoff = 0.05 S[2, 2, 1] -> K[2, 2] + S[2, -1,  1]
kpoff = 0.05 S[2, 2, 1] -> K[3, 1] + S[2, 2,  -1]
kpon = 0 K[1, 1] + S[-1, 0, 0] -> S[1, 0,  0]
kpon = 0 K[1, 1] + S[-1, 0, -1] -> S[1, 0,  -1]
kpon = 0 K[1, 1] + S[-1, 0, 1] -> S[1, 0,  1]
kpon = 0 K[1, 1] + S[-1, -1, 0] -> S[1, -1,  0]
kpon = 0 K[1, 1] + S[-1, 1, 0] -> S[1, 1,  0]
kpon = 0 K[1, 1] + S[-1, -1, -1] -> S[1, -1,  -1]
kpon = 0 K[1, 1] + S[-1, -1, 1] -> S[1, -1,  1]
kpon = 0 K[1, 1] + S[-1, 1, -1] -> S[1, 1,  -1]
kpon = 0 K[1, 1] + S[-1, 1, 1] -> S[1, 1,  1]
kpon = 0 K[1, 1] + S[-1, 2, 0] -> S[1, 2,  0]
kpon = 0 K[1, 1] + S[-1, 2, -1] -> S[1, 2,  -1]
kpon = 0 K[1, 1] + S[-1, 2, 1] -> S[1, 2,  1]
kpon = 0 K[1, 2] + S[-1, 0, 0] -> S[2, 0,  0]
kpon = 0 K[1, 2] + S[-1, 0, -1] -> S[2, 0,  -1]
kpon = 0 K[1, 2] + S[-1, 0, 1] -> S[2, 0,  1]
kpon = 0 K[1, 2] + S[-1, -1, 0] -> S[2, -1,  0]
kpon = 0 K[1, 2] + S[-1, 1, 0] -> S[2, 1,  0]
kpon = 0 K[1, 2] + S[-1, -1, -1] -> S[2, -1,  -1]
kpon = 0 K[1, 2] + S[-1, -1, 1] -> S[2, -1,  1]
kpon = 0 K[1, 2] + S[-1, 1, -1] -> S[2, 1,  -1]
kpon = 0 K[1, 2] + S[-1, 1, 1] -> S[2, 1,  1]
kpon = 0 K[1, 2] + S[-1, 2, 0] -> S[2, 2,  0]
kpon = 0 K[1, 2] + S[-1, 2, -1] -> S[2, 2,  -1]
kpon = 0 K[1, 2] + S[-1, 2, 1] -> S[2, 2,  1]
kpon = 0 K[2, 1] + S[0, -1, 0] -> S[0, 1,  0]
kpon = 0 K[2, 1] + S[0, -1, -1] -> S[0, 1,  -1]
kpon = 0 K[2, 1] + S[0, -1, 1] -> S[0, 1,  1]
kpon = 0 K[2, 1] + S[-1, -1, 0] -> S[-1, 1,  0]
kpon = 0 K[2, 1] + S[1, -1, 0] -> S[1, 1,  0]
kpon = 0 K[2, 1] + S[-1, -1, -1] -> S[-1, 1,  -1]
kpon = 0 K[2, 1] + S[-1, -1, 1] -> S[-1, 1,  1]
kpon = 0 K[2, 1] + S[1, -1, -1] -> S[1, 1,  -1]
kpon = 0 K[2, 1] + S[1, -1, 1] -> S[1, 1,  1]
kpon = 0 K[2, 1] + S[2, -1, 0] -> S[2, 1,  0]
kpon = 0 K[2, 1] + S[2, -1, -1] -> S[2, 1,  -1]
kpon = 0 K[2, 1] + S[2, -1, 1] -> S[2, 1,  1]
kpon = 0 K[2, 2] + S[0, -1, 0] -> S[0, 2,  0]
kpon = 0 K[2, 2] + S[0, -1, -1] -> S[0, 2,  -1]
kpon = 0 K[2, 2] + S[0, -1, 1] -> S[0, 2,  1]
kpon = 0 K[2, 2] + S[-1, -1, 0] -> S[-1, 2,  0]
kpon = 0 K[2, 2] + S[1, -1, 0] -> S[1, 2,  0]
kpon = 0 K[2, 2] + S[-1, -1, -1] -> S[-1, 2,  -1]
kpon = 0 K[2, 2] + S[-1, -1, 1] -> S[-1, 2,  1]
kpon = 0 K[2, 2] + S[1, -1, -1] -> S[1, 2,  -1]
kpon = 0 K[2, 2] + S[1, -1, 1] -> S[1, 2,  1]
kpon = 0 K[2, 2] + S[2, -1, 0] -> S[2, 2,  0]
kpon = 0 K[2, 2] + S[2, -1, -1] -> S[2, 2,  -1]
kpon = 0 K[2, 2] + S[2, -1, 1] -> S[2, 2,  1]
kpon = 0 K[3, 1] + S[0, 0, -1] -> S[0, 0,  1]
kpon = 0 K[3, 1] + S[0, -1, -1] -> S[0, -1,  1]
kpon = 0 K[3, 1] + S[0, 1, -1] -> S[0, 1,  1]
kpon = 0 K[3, 1] + S[0, 2, -1] -> S[0, 2,  1]
kpon = 0 K[3, 1] + S[-1, 0, -1] -> S[-1, 0,  1]
kpon = 0 K[3, 1] + S[1, 0, -1] -> S[1, 0,  1]
kpon = 0 K[3, 1] + S[-1, -1, -1] -> S[-1, -1,  1]
kpon = 0 K[3, 1] + S[-1, 1, -1] -> S[-1, 1,  1]
kpon = 0 K[3, 1] + S[1, -1, -1] -> S[1, -1,  1]
kpon = 0 K[3, 1] + S[1, 1, -1] -> S[1, 1,  1]
kpon = 0 K[3, 1] + S[-1, 2, -1] -> S[-1, 2,  1]
kpon = 0 K[3, 1] + S[1, 2, -1] -> S[1, 2,  1]
kpon = 0 K[3, 1] + S[2, 0, -1] -> S[2, 0,  1]
kpon = 0 K[3, 1] + S[2, -1, -1] -> S[2, -1,  1]
kpon = 0 K[3, 1] + S[2, 1, -1] -> S[2, 1,  1]
kpon = 0 K[3, 1] + S[2, 2, -1] -> S[2, 2,  1]
Variable IC   ODE
MAPKP 0.3 MAPKP'[t] == -(a8*MAPKP[t]*K[1, 1][t]) - a10*MAPKP[ t]*K[1, 2][t] + d8*K_MAPKP[1, 1][t] + k8*K_MAPKP[ 1, 1][t] + d10*K_MAPKP[1, 2][t] + k10*K_MAPKP[1,  2][t]
MEKP 0.2 MEKP'[t] == -(a4*MEKP[t]*K[2, 1][t]) - a6*MEKP[t]* K[2, 2][t] + d4*K_MEKP[2, 1][t] + k4*K_MEKP[2,  1][t] + d6*K_MEKP[2, 2][t] + k6*K_MEKP[2, 2] [t]
RAFK 0.1 RAFK'[t] == -(a1*RAFK[t]*K[3, 0][t]) + d1*K_RAFK[3,  0][t] + k1*K_RAFK[3, 0][t] - k1a*RAFK[t]*S[-1,  -1, 0][t] - k1a*RAFK[t]*S[-1, 0, 0][t] -  k1a*RAFK[t]*S[-1, 1, 0][t] - k1a*RAFK[t]*S[-1, 2,  0][t] - k1a*RAFK[t]*S[0, -1, 0][t] - k1a* RAFK[t]*S[0, 0, 0][t] - k1a*RAFK[t]*S[0, 1, 0][t]  - k1a*RAFK[t]*S[0, 2, 0][t] - k1a*RAFK[t]*S[1,  -1, 0][t] - k1a*RAFK[t]*S[1, 0, 0][t] -  k1a*RAFK[t]*S[1, 1, 0][t] - k1a*RAFK[t]*S[1, 2,  0][t] - k1a*RAFK[t]*S[2, -1, 0][t] - k1a* RAFK[t]*S[2, 0, 0][t] - k1a*RAFK[t]*S[2, 1, 0][t]  - k1a*RAFK[t]*S[2, 2, 0][t] + d1a*S_RAFK[-1,  -1, 0][t] + k1*S_RAFK[-1, -1, 0][t] +  d1a*S_RAFK[-1, 0, 0][t] + k1*S_RAFK[-1, 0,  0][t] + d1a*S_RAFK[-1, 1, 0][t] + k1*S_RAFK[ -1, 1, 0][t] + d1a*S_RAFK[-1, 2, 0][t] +  k1*S_RAFK[-1, 2, 0][t] + d1a*S_RAFK[0, -1,  0][t] + k1*S_RAFK[0, -1, 0][t] + d1a*S_RAFK[ 0, 0, 0][t] + k1*S_RAFK[0, 0, 0][t] +  d1a*S_RAFK[0, 1, 0][t] + k1*S_RAFK[0, 1, 0][ t] + d1a*S_RAFK[0, 2, 0][t] + k1*S_RAFK[0, 2,  0][t] + d1a*S_RAFK[1, -1, 0][t] + k1*S_RAFK[ 1, -1, 0][t] + d1a*S_RAFK[1, 0, 0][t] +  k1*S_RAFK[1, 0, 0][t] + d1a*S_RAFK[1, 1, 0][ t] + k1*S_RAFK[1, 1, 0][t] + d1a*S_RAFK[1, 2,  0][t] + k1*S_RAFK[1, 2, 0][t] + d1a*S_RAFK[ 2, -1, 0][t] + k1*S_RAFK[2, -1, 0][t] +  d1a*S_RAFK[2, 0, 0][t] + k1*S_RAFK[2, 0, 0][ t] + d1a*S_RAFK[2, 1, 0][t] + k1*S_RAFK[2, 1,  0][t] + d1a*S_RAFK[2, 2, 0][t] + k1*S_RAFK[ 2, 2, 0][t]
RAFP 0.3 RAFP'[t] == -(a2*RAFP[t]*K[3, 1][t]) + d2*K_RAFP[3,  1][t] + k2*K_RAFP[3, 1][t]
K[1, 0] 0.4 (K[1, 0])'[t] == -(a7*K[1, 0][t]*K[2, 2][t]) +  d7*K_K[1, 0, 2, 2][t] + k8*K_MAPKP[1, 1][t]  - kon*K[1, 0][t]*S[-1, -1, -1][t] - kon*K[1,  0][t]*S[-1, -1, 0][t] - kon*K[1, 0][t]*S[-1,  -1, 1][t] - kon*K[1, 0][t]*S[-1, 0, -1][t]  - kon*K[1, 0][t]*S[-1, 0, 0][t] - kon*K[1,  0][t]*S[-1, 0, 1][t] - kon*K[1, 0][t]*S[-1,  1, -1][t] - kon*K[1, 0][t]*S[-1, 1, 0][t]  - kon*K[1, 0][t]*S[-1, 1, 1][t] - kon*K[1,  0][t]*S[-1, 2, -1][t] - kon*K[1, 0][t]*S[-1,  2, 0][t] - kon*K[1, 0][t]*S[-1, 2, 1][t]  + koff*S[0, -1, -1][t] + koff*S[0, -1,  0][t] + koff*S[0, -1, 1][t] + koff*S[0,  0, -1][t] + koff*S[0, 0, 0][t] + koff* S[0, 0, 1][t] + koff*S[0, 1, -1][t] +  koff*S[0, 1, 0][t] + koff*S[0, 1, 1][t]  + koff*S[0, 2, -1][t] + koff*S[0, 2, 0] [t] + koff*S[0, 2, 1][t]
K[1, 1] 0 (K[1, 1])'[t] == -(a8*MAPKP[t]*K[1, 1][t]) -  a9*K[1, 1][t]*K[2, 2][t] + k7*K_K[1, 0, 2,  2][t] + d9*K_K[1, 1, 2, 2][t] + d8* K_MAPKP[1, 1][t] + k10*K_MAPKP[1, 2][t] - kpon*K[ 1, 1][t]*S[-1, -1, -1][t] - kpon*K[1, 1][t]*S[-1,  -1, 0][t] - kpon*K[1, 1][t]*S[-1, -1, 1][t]  - kpon*K[1, 1][t]*S[-1, 0, -1][t] - kpon*K[ 1, 1][t]*S[-1, 0, 0][t] - kpon*K[1, 1][t]*S[-1,  0, 1][t] - kpon*K[1, 1][t]*S[-1, 1, -1][t]  - kpon*K[1, 1][t]*S[-1, 1, 0][t] - kpon*K[1,  1][t]*S[-1, 1, 1][t] - kpon*K[1, 1][t]*S[-1,  2, -1][t] - kpon*K[1, 1][t]*S[-1, 2, 0][t]  - kpon*K[1, 1][t]*S[-1, 2, 1][t] + kpoff*S[ 1, -1, -1][t] + kpoff*S[1, -1, 0][t] +  kpoff*S[1, -1, 1][t] + kpoff*S[1, 0, -1][t]  + kpoff*S[1, 0, 0][t] + kpoff*S[1, 0,  1][t] + kpoff*S[1, 1, -1][t] + kpoff*S[1,  1, 0][t] + kpoff*S[1, 1, 1][t] + kpoff* S[1, 2, -1][t] + kpoff*S[1, 2, 0][t] +  kpoff*S[1, 2, 1][t]
K[1, 2] 0 (K[1, 2])'[t] == -(a10*MAPKP[t]*K[1, 2][t]) +  k9*K_K[1, 1, 2, 2][t] + d10*K_MAPKP[1, 2][t]  - kpon*K[1, 2][t]*S[-1, -1, -1][t] - kpon*K[ 1, 2][t]*S[-1, -1, 0][t] - kpon*K[1, 2][t]*S[-1,  -1, 1][t] - kpon*K[1, 2][t]*S[-1, 0, -1][t]  - kpon*K[1, 2][t]*S[-1, 0, 0][t] - kpon*K[1,  2][t]*S[-1, 0, 1][t] - kpon*K[1, 2][t]*S[-1,  1, -1][t] - kpon*K[1, 2][t]*S[-1, 1, 0][t]  - kpon*K[1, 2][t]*S[-1, 1, 1][t] - kpon*K[1,  2][t]*S[-1, 2, -1][t] - kpon*K[1, 2][t]*S[-1,  2, 0][t] - kpon*K[1, 2][t]*S[-1, 2, 1][t]  + kpoff*S[2, -1, -1][t] + kpoff*S[2, -1,  0][t] + kpoff*S[2, -1, 1][t] + kpoff*S[2,  0, -1][t] + kpoff*S[2, 0, 0][t] +  kpoff*S[2, 0, 1][t] + kpoff*S[2, 1, -1][t]  + kpoff*S[2, 1, 0][t] + kpoff*S[2, 1,  1][t] + kpoff*S[2, 2, -1][t] + kpoff*S[2,  2, 0][t] + kpoff*S[2, 2, 1][t]
K[2, 0] 0.2 (K[2, 0])'[t] == -(a3*K[2, 0][t]*K[3, 1][t]) +  d3*K_K[2, 0, 3, 1][t] + k4*K_MEKP[2, 1][t]  - kon*K[2, 0][t]*S[-1, -1, -1][t] - kon*K[2,  0][t]*S[-1, -1, 0][t] - kon*K[2, 0][t]*S[-1,  -1, 1][t] + koff*S[-1, 0, -1][t] +  koff*S[-1, 0, 0][t] + koff*S[-1, 0, 1][t]  - kon*K[2, 0][t]*S[0, -1, -1][t] - kon*K[2,  0][t]*S[0, -1, 0][t] - kon*K[2, 0][t]*S[0, - 1, 1][t] + koff*S[0, 0, -1][t] + koff*S[0,  0, 0][t] + koff*S[0, 0, 1][t] - kon*K[ 2, 0][t]*S[1, -1, -1][t] - kon*K[2, 0][t]*S[1,  -1, 0][t] - kon*K[2, 0][t]*S[1, -1, 1][t]  + koff*S[1, 0, -1][t] + koff*S[1, 0, 0] [t] + koff*S[1, 0, 1][t] - kon*K[2, 0][t]*S[ 2, -1, -1][t] - kon*K[2, 0][t]*S[2, -1, 0][t]  - kon*K[2, 0][t]*S[2, -1, 1][t] + koff*S[2,  0, -1][t] + koff*S[2, 0, 0][t] + koff* S[2, 0, 1][t]
K[2, 1] 0 (K[2, 1])'[t] == -(a4*MEKP[t]*K[2, 1][t]) -  a5*K[2, 1][t]*K[3, 1][t] + k3*K_K[2, 0, 3,  1][t] + d5*K_K[2, 1, 3, 1][t] + d4* K_MEKP[2, 1][t] + k6*K_MEKP[2, 2][t] - kpon*K[2,  1][t]*S[-1, -1, -1][t] - kpon*K[2, 1][t]*S[-1,  -1, 0][t] - kpon*K[2, 1][t]*S[-1, -1, 1][t]  + kpoff*S[-1, 1, -1][t] + kpoff*S[-1, 1,  0][t] + kpoff*S[-1, 1, 1][t] - kpon*K[2,  1][t]*S[0, -1, -1][t] - kpon*K[2, 1][t]*S[0,  -1, 0][t] - kpon*K[2, 1][t]*S[0, -1, 1][t]  + kpoff*S[0, 1, -1][t] + kpoff*S[0, 1,  0][t] + kpoff*S[0, 1, 1][t] - kpon*K[2,  1][t]*S[1, -1, -1][t] - kpon*K[2, 1][t]*S[1,  -1, 0][t] - kpon*K[2, 1][t]*S[1, -1, 1][t]  + kpoff*S[1, 1, -1][t] + kpoff*S[1, 1,  0][t] + kpoff*S[1, 1, 1][t] - kpon*K[2,  1][t]*S[2, -1, -1][t] - kpon*K[2, 1][t]*S[2,  -1, 0][t] - kpon*K[2, 1][t]*S[2, -1, 1][t]  + kpoff*S[2, 1, -1][t] + kpoff*S[2, 1,  0][t] + kpoff*S[2, 1, 1][t]
K[2, 2] 0 (K[2, 2])'[t] == -(a6*MEKP[t]*K[2, 2][t]) -  a7*K[1, 0][t]*K[2, 2][t] - a9*K[1, 1][t]*K[2,  2][t] + d7*K_K[1, 0, 2, 2][t] + k7*K_K[ 1, 0, 2, 2][t] + d9*K_K[1, 1, 2, 2][t]  + k9*K_K[1, 1, 2, 2][t] + k5*K_K[2, 1,  3, 1][t] + d6*K_MEKP[2, 2][t] - kpon*K[2,  2][t]*S[-1, -1, -1][t] - kpon*K[2, 2][t]*S[-1,  -1, 0][t] - kpon*K[2, 2][t]*S[-1, -1, 1][t]  + kpoff*S[-1, 2, -1][t] + kpoff*S[-1, 2,  0][t] + kpoff*S[-1, 2, 1][t] - kpon*K[2,  2][t]*S[0, -1, -1][t] - kpon*K[2, 2][t]*S[0,  -1, 0][t] - kpon*K[2, 2][t]*S[0, -1, 1][t]  + kpoff*S[0, 2, -1][t] + kpoff*S[0, 2,  0][t] + kpoff*S[0, 2, 1][t] - kpon*K[2,  2][t]*S[1, -1, -1][t] - kpon*K[2, 2][t]*S[1,  -1, 0][t] - kpon*K[2, 2][t]*S[1, -1, 1][t]  + kpoff*S[1, 2, -1][t] + kpoff*S[1, 2,  0][t] + kpoff*S[1, 2, 1][t] - kpon*K[2,  2][t]*S[2, -1, -1][t] - kpon*K[2, 2][t]*S[2,  -1, 0][t] - kpon*K[2, 2][t]*S[2, -1, 1][t]  + kpoff*S[2, 2, -1][t] + kpoff*S[2, 2,  0][t] + kpoff*S[2, 2, 1][t]
K[3, 0] 0.3 (K[3, 0])'[t] == -(a1*RAFK[t]*K[3, 0][t]) +  d1*K_RAFK[3, 0][t] + k2*K_RAFP[3, 1][t] -  kon*K[3, 0][t]*S[-1, -1, -1][t] + koff*S[-1,  -1, 0][t] - kon*K[3, 0][t]*S[-1, 0, -1][t]  + koff*S[-1, 0, 0][t] - kon*K[3, 0][t]*S[-1,  1, -1][t] + koff*S[-1, 1, 0][t] - kon* K[3, 0][t]*S[-1, 2, -1][t] + koff*S[-1, 2, 0] [t] - kon*K[3, 0][t]*S[0, -1, -1][t] + koff* S[0, -1, 0][t] - kon*K[3, 0][t]*S[0, 0, -1][ t] + koff*S[0, 0, 0][t] - kon*K[3, 0][t]*S[0,  1, -1][t] + koff*S[0, 1, 0][t] - kon*K[ 3, 0][t]*S[0, 2, -1][t] + koff*S[0, 2, 0][t]  - kon*K[3, 0][t]*S[1, -1, -1][t] + koff*S[1,  -1, 0][t] - kon*K[3, 0][t]*S[1, 0, -1][t]  + koff*S[1, 0, 0][t] - kon*K[3, 0][t]*S[1,  1, -1][t] + koff*S[1, 1, 0][t] - kon*K[ 3, 0][t]*S[1, 2, -1][t] + koff*S[1, 2, 0][t]  - kon*K[3, 0][t]*S[2, -1, -1][t] + koff*S[2,  -1, 0][t] - kon*K[3, 0][t]*S[2, 0, -1][t]  + koff*S[2, 0, 0][t] - kon*K[3, 0][t]*S[2,  1, -1][t] + koff*S[2, 1, 0][t] - kon*K[ 3, 0][t]*S[2, 2, -1][t] + koff*S[2, 2, 0][t]
K[3, 1] 0 (K[3, 1])'[t] == -(a2*RAFP[t]*K[3, 1][t]) -  a3*K[2, 0][t]*K[3, 1][t] - a5*K[2, 1][t]*K[3,  1][t] + d3*K_K[2, 0, 3, 1][t] + k3*K_K[ 2, 0, 3, 1][t] + d5*K_K[2, 1, 3, 1][t]  + k5*K_K[2, 1, 3, 1][t] + k1*K_RAFK[3,  0][t] + d2*K_RAFP[3, 1][t] - kpon*K[3, 1][t] *S[-1, -1, -1][t] + kpoff*S[-1, -1, 1][t] -  kpon*K[3, 1][t]*S[-1, 0, -1][t] + kpoff*S[-1,  0, 1][t] - kpon*K[3, 1][t]*S[-1, 1, -1][t]  + kpoff*S[-1, 1, 1][t] - kpon*K[3, 1][t]*S[- 1, 2, -1][t] + kpoff*S[-1, 2, 1][t] -  kpon*K[3, 1][t]*S[0, -1, -1][t] + kpoff*S[0,  -1, 1][t] - kpon*K[3, 1][t]*S[0, 0, -1][t]  + kpoff*S[0, 0, 1][t] - kpon*K[3, 1][t]*S[0,  1, -1][t] + kpoff*S[0, 1, 1][t] - kpon* K[3, 1][t]*S[0, 2, -1][t] + kpoff*S[0, 2, 1][ t] - kpon*K[3, 1][t]*S[1, -1, -1][t] + kpoff* S[1, -1, 1][t] - kpon*K[3, 1][t]*S[1, 0, -1][ t] + kpoff*S[1, 0, 1][t] - kpon*K[3, 1][t]*S[ 1, 1, -1][t] + kpoff*S[1, 1, 1][t] -  kpon*K[3, 1][t]*S[1, 2, -1][t] + kpoff*S[1,  2, 1][t] - kpon*K[3, 1][t]*S[2, -1, -1][t]  + kpoff*S[2, -1, 1][t] - kpon*K[3, 1][t]*S[ 2, 0, -1][t] + kpoff*S[2, 0, 1][t] -  kpon*K[3, 1][t]*S[2, 1, -1][t] + kpoff*S[2,  1, 1][t] - kpon*K[3, 1][t]*S[2, 2, -1][t]  + kpoff*S[2, 2, 1][t]
K_K[1, 0, 2, 2] 0 (K_K[1, 0, 2, 2])'[t] == a7*K[1, 0][t]*K[2,  2][t] - d7*K_K[1, 0, 2, 2][t] - k7*K_K[ 1, 0, 2, 2][t]
K_K[1, 1, 2, 2] 0 (K_K[1, 1, 2, 2])'[t] == a9*K[1, 1][t]*K[2,  2][t] - d9*K_K[1, 1, 2, 2][t] - k9*K_K[ 1, 1, 2, 2][t]
K_K[2, 0, 3, 1] 0 (K_K[2, 0, 3, 1])'[t] == a3*K[2, 0][t]*K[3,  1][t] - d3*K_K[2, 0, 3, 1][t] - k3*K_K[ 2, 0, 3, 1][t]
K_K[2, 1, 3, 1] 0 (K_K[2, 1, 3, 1])'[t] == a5*K[2, 1][t]*K[3,  1][t] - d5*K_K[2, 1, 3, 1][t] - k5*K_K[ 2, 1, 3, 1][t]
K_MAPKP[1, 1] 0 (K_MAPKP[1, 1])'[t] == a8*MAPKP[t]*K[1, 1][t] -  d8*K_MAPKP[1, 1][t] - k8*K_MAPKP[1, 1][t]
K_MAPKP[1, 2] 0 (K_MAPKP[1, 2])'[t] == a10*MAPKP[t]*K[1, 2][t] -  d10*K_MAPKP[1, 2][t] - k10*K_MAPKP[1, 2][t]
K_MEKP[2, 1] 0 (K_MEKP[2, 1])'[t] == a4*MEKP[t]*K[2, 1][t] -  d4*K_MEKP[2, 1][t] - k4*K_MEKP[2, 1][t]
K_MEKP[2, 2] 0 (K_MEKP[2, 2])'[t] == a6*MEKP[t]*K[2, 2][t] -  d6*K_MEKP[2, 2][t] - k6*K_MEKP[2, 2][t]
K_RAFK[3, 0] 0 (K_RAFK[3, 0])'[t] == a1*RAFK[t]*K[3, 0][t] -  d1*K_RAFK[3, 0][t] - k1*K_RAFK[3, 0][t]
K_RAFP[3, 1] 0 (K_RAFP[3, 1])'[t] == a2*RAFP[t]*K[3, 1][t] -  d2*K_RAFP[3, 1][t] - k2*K_RAFP[3, 1][t]
S[-1, -1, -1] 0.1 (S[-1, -1, -1])'[t] == -(kon*K[1, 0][t]*S[-1,  -1, -1][t]) - kpon*K[1, 1][t]*S[-1, -1, -1][ t] - kpon*K[1, 2][t]*S[-1, -1, -1][t] - kon* K[2, 0][t]*S[-1, -1, -1][t] - kpon*K[2, 1][t]*S[- 1, -1, -1][t] - kpon*K[2, 2][t]*S[-1, -1, -1] [t] - kon*K[3, 0][t]*S[-1, -1, -1][t] - kpon* K[3, 1][t]*S[-1, -1, -1][t] + koff*S[-1, -1,  0][t] + kpoff*S[-1, -1, 1][t] + koff*S[-1,  0, -1][t] + kpoff*S[-1, 1, -1][t] +  kpoff*S[-1, 2, -1][t] + koff*S[0, -1, -1][t]  + kpoff*S[1, -1, -1][t] + kpoff*S[2, -1,  -1][t]
S[-1, -1, 0] 0 (S[-1, -1, 0])'[t] == kon*K[3, 0][t]*S[-1, -1,  -1][t] - koff*S[-1, -1, 0][t] - k1a*RAFK[t]* S[-1, -1, 0][t] - kon*K[1, 0][t]*S[-1, -1, 0] [t] - kpon*K[1, 1][t]*S[-1, -1, 0][t] - kpon* K[1, 2][t]*S[-1, -1, 0][t] - kon*K[2, 0][t]*S[-1,  -1, 0][t] - kpon*K[2, 1][t]*S[-1, -1, 0][t]  - kpon*K[2, 2][t]*S[-1, -1, 0][t] + koff*S[- 1, 0, 0][t] + kpoff*S[-1, 1, 0][t] +  kpoff*S[-1, 2, 0][t] + koff*S[0, -1, 0][t]  + kpoff*S[1, -1, 0][t] + kpoff*S[2, -1,  0][t] + d1a*S_RAFK[-1, -1, 0][t]
S[-1, -1, 1] 0 (S[-1, -1, 1])'[t] == kpon*K[3, 1][t]*S[-1, - 1, -1][t] - kpoff*S[-1, -1, 1][t] - kon*K[1,  0][t]*S[-1, -1, 1][t] - kpon*K[1, 1][t]*S[-1,  -1, 1][t] - kpon*K[1, 2][t]*S[-1, -1, 1][t]  - kon*K[2, 0][t]*S[-1, -1, 1][t] - kpon*K[2,  1][t]*S[-1, -1, 1][t] - kpon*K[2, 2][t]*S[-1,  -1, 1][t] + koff*S[-1, 0, 1][t] +  kpoff*S[-1, 1, 1][t] + kpoff*S[-1, 2, 1][t]  + koff*S[0, -1, 1][t] + kpoff*S[1, -1,  1][t] + kpoff*S[2, -1, 1][t] + k1*S_RAFK[-1,  -1, 0][t]
S[-1, 0, -1] 0 (S[-1, 0, -1])'[t] == kon*K[2, 0][t]*S[-1, -1,  -1][t] - koff*S[-1, 0, -1][t] - kon*K[1,  0][t]*S[-1, 0, -1][t] - kpon*K[1, 1][t]*S[-1,  0, -1][t] - kpon*K[1, 2][t]*S[-1, 0, -1][t]  - kon*K[3, 0][t]*S[-1, 0, -1][t] - kpon*K[3,  1][t]*S[-1, 0, -1][t] + koff*S[-1, 0, 0][t]  + kpoff*S[-1, 0, 1][t] + koff*S[0, 0, - 1][t] + kpoff*S[1, 0, -1][t] + kpoff*S[2, 0,  -1][t]
S[-1, 0, 0] 0 (S[-1, 0, 0])'[t] == kon*K[2, 0][t]*S[-1, -1,  0][t] + kon*K[3, 0][t]*S[-1, 0, -1][t] -  2*koff*S[-1, 0, 0][t] - k1a*RAFK[t]*S[-1, 0,  0][t] - kon*K[1, 0][t]*S[-1, 0, 0][t] -  kpon*K[1, 1][t]*S[-1, 0, 0][t] - kpon*K[1,  2][t]*S[-1, 0, 0][t] + koff*S[0, 0, 0][t]  + kpoff*S[1, 0, 0][t] + kpoff*S[2, 0,  0][t] + d1a*S_RAFK[-1, 0, 0][t]
S[-1, 0, 1] 0 (S[-1, 0, 1])'[t] == kon*K[2, 0][t]*S[-1, -1,  1][t] + kpon*K[3, 1][t]*S[-1, 0, -1][t] -  k3*S[-1, 0, 1][t] - koff*S[-1, 0, 1][t]  - kpoff*S[-1, 0, 1][t] - kon*K[1, 0][t]*S[- 1, 0, 1][t] - kpon*K[1, 1][t]*S[-1, 0, 1][t]  - kpon*K[1, 2][t]*S[-1, 0, 1][t] + koff*S[0,  0, 1][t] + kpoff*S[1, 0, 1][t] + kpoff* S[2, 0, 1][t] + k1*S_RAFK[-1, 0, 0][t]
S[-1, 1, -1] 0 (S[-1, 1, -1])'[t] == kpon*K[2, 1][t]*S[-1, - 1, -1][t] - kpoff*S[-1, 1, -1][t] - kon*K[1,  0][t]*S[-1, 1, -1][t] - kpon*K[1, 1][t]*S[-1,  1, -1][t] - kpon*K[1, 2][t]*S[-1, 1, -1][t]  - kon*K[3, 0][t]*S[-1, 1, -1][t] - kpon*K[3,  1][t]*S[-1, 1, -1][t] + koff*S[-1, 1, 0][t]  + kpoff*S[-1, 1, 1][t] + koff*S[0, 1, - 1][t] + kpoff*S[1, 1, -1][t] + kpoff*S[2, 1,  -1][t]
S[-1, 1, 0] 0 (S[-1, 1, 0])'[t] == kpon*K[2, 1][t]*S[-1, -1,  0][t] + kon*K[3, 0][t]*S[-1, 1, -1][t] -  koff*S[-1, 1, 0][t] - kpoff*S[-1, 1, 0][t]  - k1a*RAFK[t]*S[-1, 1, 0][t] - kon*K[1, 0][ t]*S[-1, 1, 0][t] - kpon*K[1, 1][t]*S[-1, 1,  0][t] - kpon*K[1, 2][t]*S[-1, 1, 0][t] +  koff*S[0, 1, 0][t] + kpoff*S[1, 1, 0][t]  + kpoff*S[2, 1, 0][t] + d1a*S_RAFK[-1, 1,  0][t]
S[-1, 1, 1] 0 (S[-1, 1, 1])'[t] == kpon*K[2, 1][t]*S[-1, -1,  1][t] + k3*S[-1, 0, 1][t] + kpon*K[3,  1][t]*S[-1, 1, -1][t] - k5a*S[-1, 1, 1][t]  - 2*kpoff*S[-1, 1, 1][t] - kon*K[1, 0][t]*S[ -1, 1, 1][t] - kpon*K[1, 1][t]*S[-1, 1, 1][t]  - kpon*K[1, 2][t]*S[-1, 1, 1][t] + koff*S[0,  1, 1][t] + kpoff*S[1, 1, 1][t] + kpoff* S[2, 1, 1][t] + k1*S_RAFK[-1, 1, 0][t]
S[-1, 2, -1] 0 (S[-1, 2, -1])'[t] == kpon*K[2, 2][t]*S[-1, - 1, -1][t] - kpoff*S[-1, 2, -1][t] - kon*K[1,  0][t]*S[-1, 2, -1][t] - kpon*K[1, 1][t]*S[-1,  2, -1][t] - kpon*K[1, 2][t]*S[-1, 2, -1][t]  - kon*K[3, 0][t]*S[-1, 2, -1][t] - kpon*K[3,  1][t]*S[-1, 2, -1][t] + koff*S[-1, 2, 0][t]  + kpoff*S[-1, 2, 1][t] + koff*S[0, 2, - 1][t] + kpoff*S[1, 2, -1][t] + kpoff*S[2, 2,  -1][t]
S[-1, 2, 0] 0 (S[-1, 2, 0])'[t] == kpon*K[2, 2][t]*S[-1, -1,  0][t] + kon*K[3, 0][t]*S[-1, 2, -1][t] -  koff*S[-1, 2, 0][t] - kpoff*S[-1, 2, 0][t]  - k1a*RAFK[t]*S[-1, 2, 0][t] - kon*K[1, 0][ t]*S[-1, 2, 0][t] - kpon*K[1, 1][t]*S[-1, 2,  0][t] - kpon*K[1, 2][t]*S[-1, 2, 0][t] +  koff*S[0, 2, 0][t] + kpoff*S[1, 2, 0][t]  + kpoff*S[2, 2, 0][t] + d1a*S_RAFK[-1, 2,  0][t]
S[-1, 2, 1] 0 (S[-1, 2, 1])'[t] == kpon*K[2, 2][t]*S[-1, -1,  1][t] + k5a*S[-1, 1, 1][t] + kpon*K[3,  1][t]*S[-1, 2, -1][t] - 2*kpoff*S[-1, 2, 1][ t] - kon*K[1, 0][t]*S[-1, 2, 1][t] - kpon*K[ 1, 1][t]*S[-1, 2, 1][t] - kpon*K[1, 2][t]*S[-1,  2, 1][t] + koff*S[0, 2, 1][t] + kpoff* S[1, 2, 1][t] + kpoff*S[2, 2, 1][t] +  k1*S_RAFK[-1, 2, 0][t]
S[0, -1, -1] 0 (S[0, -1, -1])'[t] == kon*K[1, 0][t]*S[-1, -1,  -1][t] - koff*S[0, -1, -1][t] - kon*K[2,  0][t]*S[0, -1, -1][t] - kpon*K[2, 1][t]*S[0,  -1, -1][t] - kpon*K[2, 2][t]*S[0, -1, -1][t]  - kon*K[3, 0][t]*S[0, -1, -1][t] - kpon*K[3,  1][t]*S[0, -1, -1][t] + koff*S[0, -1, 0][t]  + kpoff*S[0, -1, 1][t] + koff*S[0, 0, - 1][t] + kpoff*S[0, 1, -1][t] + kpoff*S[0, 2,  -1][t]
S[0, -1, 0] 0 (S[0, -1, 0])'[t] == kon*K[1, 0][t]*S[-1, -1,  0][t] + kon*K[3, 0][t]*S[0, -1, -1][t] -  2*koff*S[0, -1, 0][t] - k1a*RAFK[t]*S[0, -1,  0][t] - kon*K[2, 0][t]*S[0, -1, 0][t] -  kpon*K[2, 1][t]*S[0, -1, 0][t] - kpon*K[2,  2][t]*S[0, -1, 0][t] + koff*S[0, 0, 0][t]  + kpoff*S[0, 1, 0][t] + kpoff*S[0, 2,  0][t] + d1a*S_RAFK[0, -1, 0][t]
S[0, -1, 1] 0 (S[0, -1, 1])'[t] == kon*K[1, 0][t]*S[-1, -1,  1][t] + kpon*K[3, 1][t]*S[0, -1, -1][t] -  koff*S[0, -1, 1][t] - kpoff*S[0, -1, 1][t]  - kon*K[2, 0][t]*S[0, -1, 1][t] - kpon*K[2,  1][t]*S[0, -1, 1][t] - kpon*K[2, 2][t]*S[0,  -1, 1][t] + koff*S[0, 0, 1][t] + kpoff* S[0, 1, 1][t] + kpoff*S[0, 2, 1][t] +  k1*S_RAFK[0, -1, 0][t]
S[0, 0, -1] 0 (S[0, 0, -1])'[t] == kon*K[1, 0][t]*S[-1, 0,  -1][t] + kon*K[2, 0][t]*S[0, -1, -1][t] -  2*koff*S[0, 0, -1][t] - kon*K[3, 0][t]*S[0,  0, -1][t] - kpon*K[3, 1][t]*S[0, 0, -1][t]  + koff*S[0, 0, 0][t] + kpoff*S[0, 0, 1] [t]
S[0, 0, 0] 0 (S[0, 0, 0])'[t] == kon*K[1, 0][t]*S[-1, 0,  0][t] + kon*K[2, 0][t]*S[0, -1, 0][t] +  kon*K[3, 0][t]*S[0, 0, -1][t] - 3*koff*S[0,  0, 0][t] - k1a*RAFK[t]*S[0, 0, 0][t] +  d1a*S_RAFK[0, 0, 0][t]
S[0, 0, 1] 0 (S[0, 0, 1])'[t] == kon*K[1, 0][t]*S[-1, 0,  1][t] + kon*K[2, 0][t]*S[0, -1, 1][t] +  kpon*K[3, 1][t]*S[0, 0, -1][t] - k3*S[0, 0,  1][t] - 2*koff*S[0, 0, 1][t] - kpoff*S[0,  0, 1][t] + k1*S_RAFK[0, 0, 0][t]
S[0, 1, -1] 0 (S[0, 1, -1])'[t] == kon*K[1, 0][t]*S[-1, 1,  -1][t] + kpon*K[2, 1][t]*S[0, -1, -1][t] -  koff*S[0, 1, -1][t] - kpoff*S[0, 1, -1][t]  - kon*K[3, 0][t]*S[0, 1, -1][t] - kpon*K[3,  1][t]*S[0, 1, -1][t] + koff*S[0, 1, 0][t]  + kpoff*S[0, 1, 1][t]
S[0, 1, 0] 0 (S[0, 1, 0])'[t] == kon*K[1, 0][t]*S[-1, 1,  0][t] + kpon*K[2, 1][t]*S[0, -1, 0][t] +  kon*K[3, 0][t]*S[0, 1, -1][t] - 2*koff*S[0,  1, 0][t] - kpoff*S[0, 1, 0][t] - k1a* RAFK[t]*S[0, 1, 0][t] + d1a*S_RAFK[0, 1, 0][t]
S[0, 1, 1] 0 (S[0, 1, 1])'[t] == kon*K[1, 0][t]*S[-1, 1,  1][t] + kpon*K[2, 1][t]*S[0, -1, 1][t] +  k3*S[0, 0, 1][t] + kpon*K[3, 1][t]*S[0, 1,  -1][t] - k5a*S[0, 1, 1][t] - koff*S[0,  1, 1][t] - 2*kpoff*S[0, 1, 1][t] + k1* S_RAFK[0, 1, 0][t]
S[0, 2, -1] 0 (S[0, 2, -1])'[t] == kon*K[1, 0][t]*S[-1, 2,  -1][t] + kpon*K[2, 2][t]*S[0, -1, -1][t] -  k7*S[0, 2, -1][t] - koff*S[0, 2, -1][t]  - kpoff*S[0, 2, -1][t] - kon*K[3, 0][t]*S[0,  2, -1][t] - kpon*K[3, 1][t]*S[0, 2, -1][t]  + koff*S[0, 2, 0][t] + kpoff*S[0, 2, 1] [t]
S[0, 2, 0] 0 (S[0, 2, 0])'[t] == kon*K[1, 0][t]*S[-1, 2,  0][t] + kpon*K[2, 2][t]*S[0, -1, 0][t] +  kon*K[3, 0][t]*S[0, 2, -1][t] - k7*S[0, 2,  0][t] - 2*koff*S[0, 2, 0][t] - kpoff*S[0,  2, 0][t] - k1a*RAFK[t]*S[0, 2, 0][t] +  d1a*S_RAFK[0, 2, 0][t]
S[0, 2, 1] 0 (S[0, 2, 1])'[t] == kon*K[1, 0][t]*S[-1, 2,  1][t] + kpon*K[2, 2][t]*S[0, -1, 1][t] +  k5a*S[0, 1, 1][t] + kpon*K[3, 1][t]*S[0, 2,  -1][t] - k7*S[0, 2, 1][t] - koff*S[0,  2, 1][t] - 2*kpoff*S[0, 2, 1][t] + k1* S_RAFK[0, 2, 0][t]
S[1, -1, -1] 0 (S[1, -1, -1])'[t] == kpon*K[1, 1][t]*S[-1, - 1, -1][t] - kpoff*S[1, -1, -1][t] - kon*K[2,  0][t]*S[1, -1, -1][t] - kpon*K[2, 1][t]*S[1,  -1, -1][t] - kpon*K[2, 2][t]*S[1, -1, -1][t]  - kon*K[3, 0][t]*S[1, -1, -1][t] - kpon*K[3,  1][t]*S[1, -1, -1][t] + koff*S[1, -1, 0][t]  + kpoff*S[1, -1, 1][t] + koff*S[1, 0, - 1][t] + kpoff*S[1, 1, -1][t] + kpoff*S[1, 2,  -1][t]
S[1, -1, 0] 0 (S[1, -1, 0])'[t] == kpon*K[1, 1][t]*S[-1, -1,  0][t] + kon*K[3, 0][t]*S[1, -1, -1][t] -  koff*S[1, -1, 0][t] - kpoff*S[1, -1, 0][t]  - k1a*RAFK[t]*S[1, -1, 0][t] - kon*K[2, 0][ t]*S[1, -1, 0][t] - kpon*K[2, 1][t]*S[1, -1,  0][t] - kpon*K[2, 2][t]*S[1, -1, 0][t] +  koff*S[1, 0, 0][t] + kpoff*S[1, 1, 0][t]  + kpoff*S[1, 2, 0][t] + d1a*S_RAFK[1, -1,  0][t]
S[1, -1, 1] 0 (S[1, -1, 1])'[t] == kpon*K[1, 1][t]*S[-1, -1,  1][t] + kpon*K[3, 1][t]*S[1, -1, -1][t] -  2*kpoff*S[1, -1, 1][t] - kon*K[2, 0][t]*S[1,  -1, 1][t] - kpon*K[2, 1][t]*S[1, -1, 1][t]  - kpon*K[2, 2][t]*S[1, -1, 1][t] + koff*S[1,  0, 1][t] + kpoff*S[1, 1, 1][t] + kpoff* S[1, 2, 1][t] + k1*S_RAFK[1, -1, 0][t]
S[1, 0, -1] 0 (S[1, 0, -1])'[t] == kpon*K[1, 1][t]*S[-1, 0,  -1][t] + kon*K[2, 0][t]*S[1, -1, -1][t] -  koff*S[1, 0, -1][t] - kpoff*S[1, 0, -1][t]  - kon*K[3, 0][t]*S[1, 0, -1][t] - kpon*K[3,  1][t]*S[1, 0, -1][t] + koff*S[1, 0, 0][t]  + kpoff*S[1, 0, 1][t]
S[1, 0, 0] 0 (S[1, 0, 0])'[t] == kpon*K[1, 1][t]*S[-1, 0,  0][t] + kon*K[2, 0][t]*S[1, -1, 0][t] +  kon*K[3, 0][t]*S[1, 0, -1][t] - 2*koff*S[1,  0, 0][t] - kpoff*S[1, 0, 0][t] - k1a* RAFK[t]*S[1, 0, 0][t] + d1a*S_RAFK[1, 0, 0][t]
S[1, 0, 1] 0 (S[1, 0, 1])'[t] == kpon*K[1, 1][t]*S[-1, 0,  1][t] + kon*K[2, 0][t]*S[1, -1, 1][t] +  kpon*K[3, 1][t]*S[1, 0, -1][t] - k3*S[1, 0,  1][t] - koff*S[1, 0, 1][t] - 2*kpoff*S[1,  0, 1][t] + k1*S_RAFK[1, 0, 0][t]
S[1, 1, -1] 0 (S[1, 1, -1])'[t] == kpon*K[1, 1][t]*S[-1, 1,  -1][t] + kpon*K[2, 1][t]*S[1, -1, -1][t] -  2*kpoff*S[1, 1, -1][t] - kon*K[3, 0][t]*S[1,  1, -1][t] - kpon*K[3, 1][t]*S[1, 1, -1][t]  + koff*S[1, 1, 0][t] + kpoff*S[1, 1, 1] [t]
S[1, 1, 0] 0 (S[1, 1, 0])'[t] == kpon*K[1, 1][t]*S[-1, 1,  0][t] + kpon*K[2, 1][t]*S[1, -1, 0][t] +  kon*K[3, 0][t]*S[1, 1, -1][t] - koff*S[1, 1,  0][t] - 2*kpoff*S[1, 1, 0][t] - k1a*RAFK[t]* S[1, 1, 0][t] + d1a*S_RAFK[1, 1, 0][t]
S[1, 1, 1] 0 (S[1, 1, 1])'[t] == kpon*K[1, 1][t]*S[-1, 1,  1][t] + kpon*K[2, 1][t]*S[1, -1, 1][t] +  k3*S[1, 0, 1][t] + kpon*K[3, 1][t]*S[1, 1,  -1][t] - k5a*S[1, 1, 1][t] - 3*kpoff*S[1,  1, 1][t] + k1*S_RAFK[1, 1, 0][t]
S[1, 2, -1] 0 (S[1, 2, -1])'[t] == kpon*K[1, 1][t]*S[-1, 2,  -1][t] + k7*S[0, 2, -1][t] + kpon*K[2,  2][t]*S[1, -1, -1][t] - k9a*S[1, 2, -1][t]  - 2*kpoff*S[1, 2, -1][t] - kon*K[3, 0][t]*S[ 1, 2, -1][t] - kpon*K[3, 1][t]*S[1, 2, -1][t]  + koff*S[1, 2, 0][t] + kpoff*S[1, 2, 1] [t]
S[1, 2, 0] 0 (S[1, 2, 0])'[t] == kpon*K[1, 1][t]*S[-1, 2,  0][t] + k7*S[0, 2, 0][t] + kpon*K[2, 2] [t]*S[1, -1, 0][t] + kon*K[3, 0][t]*S[1, 2, - 1][t] - k9a*S[1, 2, 0][t] - koff*S[1, 2,  0][t] - 2*kpoff*S[1, 2, 0][t] - k1a*RAFK[t]* S[1, 2, 0][t] + d1a*S_RAFK[1, 2, 0][t]
S[1, 2, 1] 0 (S[1, 2, 1])'[t] == kpon*K[1, 1][t]*S[-1, 2,  1][t] + k7*S[0, 2, 1][t] + kpon*K[2, 2] [t]*S[1, -1, 1][t] + k5a*S[1, 1, 1][t] +  kpon*K[3, 1][t]*S[1, 2, -1][t] - k9a*S[1, 2,  1][t] - 3*kpoff*S[1, 2, 1][t] + k1*S_RAFK[1,  2, 0][t]
S[2, -1, -1] 0 (S[2, -1, -1])'[t] == kpon*K[1, 2][t]*S[-1, - 1, -1][t] - kpoff*S[2, -1, -1][t] - kon*K[2,  0][t]*S[2, -1, -1][t] - kpon*K[2, 1][t]*S[2,  -1, -1][t] - kpon*K[2, 2][t]*S[2, -1, -1][t]  - kon*K[3, 0][t]*S[2, -1, -1][t] - kpon*K[3,  1][t]*S[2, -1, -1][t] + koff*S[2, -1, 0][t]  + kpoff*S[2, -1, 1][t] + koff*S[2, 0, - 1][t] + kpoff*S[2, 1, -1][t] + kpoff*S[2, 2,  -1][t]
S[2, -1, 0] 0 (S[2, -1, 0])'[t] == kpon*K[1, 2][t]*S[-1, -1,  0][t] + kon*K[3, 0][t]*S[2, -1, -1][t] -  koff*S[2, -1, 0][t] - kpoff*S[2, -1, 0][t]  - k1a*RAFK[t]*S[2, -1, 0][t] - kon*K[2, 0][ t]*S[2, -1, 0][t] - kpon*K[2, 1][t]*S[2, -1,  0][t] - kpon*K[2, 2][t]*S[2, -1, 0][t] +  koff*S[2, 0, 0][t] + kpoff*S[2, 1, 0][t]  + kpoff*S[2, 2, 0][t] + d1a*S_RAFK[2, -1,  0][t]
S[2, -1, 1] 0 (S[2, -1, 1])'[t] == kpon*K[1, 2][t]*S[-1, -1,  1][t] + kpon*K[3, 1][t]*S[2, -1, -1][t] -  2*kpoff*S[2, -1, 1][t] - kon*K[2, 0][t]*S[2,  -1, 1][t] - kpon*K[2, 1][t]*S[2, -1, 1][t]  - kpon*K[2, 2][t]*S[2, -1, 1][t] + koff*S[2,  0, 1][t] + kpoff*S[2, 1, 1][t] + kpoff* S[2, 2, 1][t] + k1*S_RAFK[2, -1, 0][t]
S[2, 0, -1] 0 (S[2, 0, -1])'[t] == kpon*K[1, 2][t]*S[-1, 0,  -1][t] + kon*K[2, 0][t]*S[2, -1, -1][t] -  koff*S[2, 0, -1][t] - kpoff*S[2, 0, -1][t]  - kon*K[3, 0][t]*S[2, 0, -1][t] - kpon*K[3,  1][t]*S[2, 0, -1][t] + koff*S[2, 0, 0][t]  + kpoff*S[2, 0, 1][t]
S[2, 0, 0] 0 (S[2, 0, 0])'[t] == kpon*K[1, 2][t]*S[-1, 0,  0][t] + kon*K[2, 0][t]*S[2, -1, 0][t] +  kon*K[3, 0][t]*S[2, 0, -1][t] - 2*koff*S[2,  0, 0][t] - kpoff*S[2, 0, 0][t] - k1a* RAFK[t]*S[2, 0, 0][t] + d1a*S_RAFK[2, 0, 0][t]
S[2, 0, 1] 0 (S[2, 0, 1])'[t] == kpon*K[1, 2][t]*S[-1, 0,  1][t] + kon*K[2, 0][t]*S[2, -1, 1][t] +  kpon*K[3, 1][t]*S[2, 0, -1][t] - k3*S[2, 0,  1][t] - koff*S[2, 0, 1][t] - 2*kpoff*S[2,  0, 1][t] + k1*S_RAFK[2, 0, 0][t]
S[2, 1, -1] 0 (S[2, 1, -1])'[t] == kpon*K[1, 2][t]*S[-1, 1,  -1][t] + kpon*K[2, 1][t]*S[2, -1, -1][t] -  2*kpoff*S[2, 1, -1][t] - kon*K[3, 0][t]*S[2,  1, -1][t] - kpon*K[3, 1][t]*S[2, 1, -1][t]  + koff*S[2, 1, 0][t] + kpoff*S[2, 1, 1] [t]
S[2, 1, 0] 0 (S[2, 1, 0])'[t] == kpon*K[1, 2][t]*S[-1, 1,  0][t] + kpon*K[2, 1][t]*S[2, -1, 0][t] +  kon*K[3, 0][t]*S[2, 1, -1][t] - koff*S[2, 1,  0][t] - 2*kpoff*S[2, 1, 0][t] - k1a*RAFK[t]* S[2, 1, 0][t] + d1a*S_RAFK[2, 1, 0][t]
S[2, 1, 1] 0 (S[2, 1, 1])'[t] == kpon*K[1, 2][t]*S[-1, 1,  1][t] + kpon*K[2, 1][t]*S[2, -1, 1][t] +  k3*S[2, 0, 1][t] + kpon*K[3, 1][t]*S[2, 1,  -1][t] - k5a*S[2, 1, 1][t] - 3*kpoff*S[2,  1, 1][t] + k1*S_RAFK[2, 1, 0][t]
S[2, 2, -1] 0 (S[2, 2, -1])'[t] == kpon*K[1, 2][t]*S[-1, 2,  -1][t] + k9a*S[1, 2, -1][t] + kpon*K[2,  2][t]*S[2, -1, -1][t] - 2*kpoff*S[2, 2, -1][ t] - kon*K[3, 0][t]*S[2, 2, -1][t] - kpon*K[ 3, 1][t]*S[2, 2, -1][t] + koff*S[2, 2, 0][t]  + kpoff*S[2, 2, 1][t]
S[2, 2, 0] 0 (S[2, 2, 0])'[t] == kpon*K[1, 2][t]*S[-1, 2,  0][t] + k9a*S[1, 2, 0][t] + kpon*K[2,  2][t]*S[2, -1, 0][t] + kon*K[3, 0][t]*S[2,  2, -1][t] - koff*S[2, 2, 0][t] - 2* kpoff*S[2, 2, 0][t] - k1a*RAFK[t]*S[2, 2, 0][t]  + d1a*S_RAFK[2, 2, 0][t]
S[2, 2, 1] 0 (S[2, 2, 1])'[t] == kpon*K[1, 2][t]*S[-1, 2,  1][t] + k9a*S[1, 2, 1][t] + kpon*K[2,  2][t]*S[2, -1, 1][t] + k5a*S[2, 1, 1][t]  + kpon*K[3, 1][t]*S[2, 2, -1][t] - 3*kpoff* S[2, 2, 1][t] + k1*S_RAFK[2, 2, 0][t]
S_RAFK[-1, -1, 0] 0 (S_RAFK[-1, -1, 0])'[t] == k1a*RAFK[t]*S[-1, -1,  0][t] - d1a*S_RAFK[-1, -1, 0][t] - k1* S_RAFK[-1, -1, 0][t]
S_RAFK[-1, 0, 0] 0 (S_RAFK[-1, 0, 0])'[t] == k1a*RAFK[t]*S[-1, 0,  0][t] - d1a*S_RAFK[-1, 0, 0][t] - k1*S_RAFK[ -1, 0, 0][t]
S_RAFK[-1, 1, 0] 0 (S_RAFK[-1, 1, 0])'[t] == k1a*RAFK[t]*S[-1, 1,  0][t] - d1a*S_RAFK[-1, 1, 0][t] - k1*S_RAFK[ -1, 1, 0][t]
S_RAFK[-1, 2, 0] 0 (S_RAFK[-1, 2, 0])'[t] == k1a*RAFK[t]*S[-1, 2,  0][t] - d1a*S_RAFK[-1, 2, 0][t] - k1*S_RAFK[ -1, 2, 0][t]
S_RAFK[0, -1, 0] 0 (S_RAFK[0, -1, 0])'[t] == k1a*RAFK[t]*S[0, -1,  0][t] - d1a*S_RAFK[0, -1, 0][t] - k1*S_RAFK[ 0, -1, 0][t]
S_RAFK[0, 0, 0] 0 (S_RAFK[0, 0, 0])'[t] == k1a*RAFK[t]*S[0, 0,  0][t] - d1a*S_RAFK[0, 0, 0][t] - k1*S_RAFK[ 0, 0, 0][t]
S_RAFK[0, 1, 0] 0 (S_RAFK[0, 1, 0])'[t] == k1a*RAFK[t]*S[0, 1,  0][t] - d1a*S_RAFK[0, 1, 0][t] - k1*S_RAFK[ 0, 1, 0][t]
S_RAFK[0, 2, 0] 0 (S_RAFK[0, 2, 0])'[t] == k1a*RAFK[t]*S[0, 2,  0][t] - d1a*S_RAFK[0, 2, 0][t] - k1*S_RAFK[ 0, 2, 0][t]
S_RAFK[1, -1, 0] 0 (S_RAFK[1, -1, 0])'[t] == k1a*RAFK[t]*S[1, -1,  0][t] - d1a*S_RAFK[1, -1, 0][t] - k1*S_RAFK[ 1, -1, 0][t]
S_RAFK[1, 0, 0] 0 (S_RAFK[1, 0, 0])'[t] == k1a*RAFK[t]*S[1, 0,  0][t] - d1a*S_RAFK[1, 0, 0][t] - k1*S_RAFK[ 1, 0, 0][t]
S_RAFK[1, 1, 0] 0 (S_RAFK[1, 1, 0])'[t] == k1a*RAFK[t]*S[1, 1,  0][t] - d1a*S_RAFK[1, 1, 0][t] - k1*S_RAFK[ 1, 1, 0][t]
S_RAFK[1, 2, 0] 0 (S_RAFK[1, 2, 0])'[t] == k1a*RAFK[t]*S[1, 2,  0][t] - d1a*S_RAFK[1, 2, 0][t] - k1*S_RAFK[ 1, 2, 0][t]
S_RAFK[2, -1, 0] 0 (S_RAFK[2, -1, 0])'[t] == k1a*RAFK[t]*S[2, -1,  0][t] - d1a*S_RAFK[2, -1, 0][t] - k1*S_RAFK[ 2, -1, 0][t]
S_RAFK[2, 0, 0] 0 (S_RAFK[2, 0, 0])'[t] == k1a*RAFK[t]*S[2, 0,  0][t] - d1a*S_RAFK[2, 0, 0][t] - k1*S_RAFK[ 2, 0, 0][t]
S_RAFK[2, 1, 0] 0 (S_RAFK[2, 1, 0])'[t] == k1a*RAFK[t]*S[2, 1,  0][t] - d1a*S_RAFK[2, 1, 0][t] - k1*S_RAFK[ 2, 1, 0][t]
S_RAFK[2, 2, 0] 0 (S_RAFK[2, 2, 0])'[t] == k1a*RAFK[t]*S[2, 2,  0][t] - d1a*S_RAFK[2, 2, 0][t] - k1*S_RAFK[ 2, 2, 0][t]

Generated by Cellerator Version 1.0 update 2.1203 using Mathematica 4.2 for Mac OS X (June 4, 2002), December 4, 2002 15:06:10, using (PowerMac,PowerPC,Mac OS X,MacOSX,Darwin)

author=B.E.Shapiro

Model
Publication ID: 10823939 Submission Date: 13 Sep 2005 13:07:14 UTC Last Modification Date: 03 Jun 2013 13:36:47 UTC Creation Date: 25 Feb 2005 23:43:21 UTC
Mathematical expressions
Reactions
binding of RAF and RAFK dissociation of RAF_RAFK phosphorylation of RAF binding of RAF-P and RAF phosphatase
dissociation of RAF-P_RAFPase dephosphorylation of RAF-P binding of MEK and RAF-P dissociation of MEK_RAF-P
phosphorylation of MEK binding of MEK-P and MEK phosphatase dissociation of MEK-P_MEKPase dephosphorylation of MEK-P
binding of MEK-P and RAF-P dissociation of MEK-P_RAF-P phosphorylation of MEK-P binding of MEK-PP and MEK phosphatase
dissociation of MEK-PP_MEKPase dephosphorylation of MEK-PP binding of MAPK and MEK-PP dissociation of MAPK_MEK-PP
phosphorylation of MAPK binding of MAPK-P and MAPK phosphatase dissociation of MAPK-P_MAPKPase dephosphorylation of MAPK-P
binding of MAPK-P and MEK-PP dissociation of MAPK-P_MEK-PP phosphorylation of MAPK-P binding of MAPK-PP and MAPK phosphatase
dissociation of MAPK-PP_MAPKPase dephosphorylation of MAPK-PP binding of MAPK on scaffold dissociation of MAPK from scaffold
binding of MAPK on scaffold dissociation of MAPK from scaffold binding of MAPK on scaffold dissociation of MAPK from scaffold
binding of MAPK on scaffold dissociation of MAPK from scaffold binding of MAPK on scaffold dissociation of MAPK from scaffold
binding of MAPK on scaffold dissociation of MAPK from scaffold binding of MAPK on scaffold dissociation of MAPK from scaffold
binding of MAPK on scaffold dissociation of MAPK from scaffold binding of MAPK on scaffold dissociation of MAPK from scaffold
binding of MAPK on scaffold dissociation of MAPK from scaffold binding of MAPK on scaffold dissociation of MAPK from scaffold
binding of MAPK on scaffold dissociation of MAPK from scaffold binding of MAPK-P on scaffold dissociation of MAPK-P from scaffold
binding of MAPK-P on scaffold dissociation of MAPK-P from scaffold binding of MAPK-P on scaffold dissociation of MAPK-P from scaffold
binding of MAPK-P on scaffold dissociation of MAPK-P from scaffold binding of MAPK-P on scaffold dissociation of MAPK-P from scaffold
binding of MAPK-P on scaffold dissociation of MAPK-P from scaffold binding of MAPK-P on scaffold dissociation of MAPK-P from scaffold
binding of MAPK-P on scaffold dissociation of MAPK-P from scaffold binding of MAPK-P on scaffold dissociation of MAPK-P from scaffold
binding of MAPK-P on scaffold dissociation of MAPK-P from scaffold binding of MAPK-P on scaffold dissociation of MAPK-P from scaffold
binding of MAPK-P on scaffold dissociation of MAPK-P from scaffold binding of MAPK-PP on scaffold dissociation of MAPK-PP from scaffold
binding of MAPK-PP on scaffold dissociation of MAPK-PP from scaffold binding of MAPK-PP on scaffold dissociation of MAPK-PP from scaffold
binding of MAPK-PP on scaffold dissociation of MAPK-PP from scaffold binding of MAPK-PP on scaffold dissociation of MAPK-PP from scaffold
binding of MAPK-PP on scaffold dissociation of MAPK-PP from scaffold binding of MAPK-PP on scaffold dissociation of MAPK-PP from scaffold
binding of MAPK-PP on scaffold dissociation of MAPK-PP from scaffold binding of MAPK-PP on scaffold dissociation of MAPK-PP from scaffold
binding of MAPK-PP on scaffold dissociation of MAPK-PP from scaffold binding of MAPK-PP on scaffold dissociation of MAPK-PP from scaffold
binding of MAPK-PP on scaffold dissociation of MAPK-PP from scaffold binding of MEK on scaffold dissociation of MEK from scaffold
binding of MEK on scaffold dissociation of MEK from scaffold binding of MEK on scaffold dissociation of MEK from scaffold
binding of MEK-P on scaffold dissociation of MEK-P from scaffold binding of MEK-P on scaffold dissociation of MEK-P from scaffold
binding of MEK-P on scaffold dissociation of MEK-P from scaffold binding of MEK-PP on scaffold dissociation of MEK-PP from scaffold
binding of MEK-PP on scaffold dissociation of MEK-PP from scaffold binding of MEK-PP on scaffold dissociation of MEK-PP from scaffold
binding of MEK on scaffold dissociation of MEK from scaffold binding of MEK on scaffold dissociation of MEK from scaffold
binding of MEK on scaffold dissociation of MEK from scaffold binding of MEK-P on scaffold dissociation of MEK-P from scaffold
binding of MEK-P on scaffold dissociation of MEK-P from scaffold binding of MEK-P on scaffold dissociation of MEK-P from scaffold
binding of MEK-PP on scaffold dissociation of MEK-PP from scaffold binding of MEK-PP on scaffold dissociation of MEK-PP from scaffold
binding of MEK-PP on scaffold dissociation of MEK-PP from scaffold binding of MEK on scaffold dissociation of MEK from scaffold
binding of MEK on scaffold dissociation of MEK from scaffold binding of MEK on scaffold dissociation of MEK from scaffold
binding of MEK-P on scaffold dissociation of MEK-P from scaffold binding of MEK-P on scaffold dissociation of MEK-P from scaffold
binding of MEK-P on scaffold dissociation of MEK-P from scaffold binding of MEK-PP on scaffold dissociation of MEK-PP from scaffold
binding of MEK-PP on scaffold dissociation of MEK-PP from scaffold binding of MEK-PP on scaffold dissociation of MEK-PP from scaffold
binding of MEK on scaffold dissociation of MEK from scaffold binding of MEK on scaffold dissociation of MEK from scaffold
binding of MEK on scaffold dissociation of MEK from scaffold binding of MEK-P on scaffold dissociation of MEK-P from scaffold
binding of MEK-P on scaffold dissociation of MEK-P from scaffold binding of MEK-P on scaffold dissociation of MEK-P from scaffold
binding of MEK-PP on scaffold dissociation of MEK-PP from scaffold binding of MEK-PP on scaffold dissociation of MEK-PP from scaffold
binding of MEK-PP on scaffold dissociation of MEK-PP from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold binding of RAF on scaffold dissociation of RAF from scaffold
binding of RAF-P on scaffold dissociation of RAF-P from scaffold phosphorylation of MAPK on scaffold phosphorylation of MAPK on scaffold
phosphorylation of MAPK on scaffold phosphorylation of MAPK-P on scaffold phosphorylation of MAPK-P on scaffold phosphorylation of MAPK-P on scaffold
phosphorylation of MEK on scaffold phosphorylation of MEK-P on scaffold phosphorylation of MEK on scaffold phosphorylation of MEK-P on scaffold
phosphorylation of MEK on scaffold phosphorylation of MEK-P on scaffold phosphorylation of MEK on scaffold phosphorylation of MEK-P on scaffold
binding of RAF and RAFK dissociation of RAF_RAFK phosphorylation of RAF on scaffold binding of RAF and RAFK
dissociation of RAF_RAFK phosphorylation of RAF on scaffold binding of RAF and RAFK dissociation of RAF_RAFK
phosphorylation of RAF on scaffold binding of RAF and RAFK dissociation of RAF_RAFK phosphorylation of RAF on scaffold
binding of RAF and RAFK dissociation of RAF_RAFK phosphorylation of RAF on scaffold binding of RAF and RAFK
dissociation of RAF_RAFK phosphorylation of RAF on scaffold binding of RAF and RAFK dissociation of RAF_RAFK
phosphorylation of RAF on scaffold binding of RAF and RAFK dissociation of RAF_RAFK phosphorylation of RAF on scaffold
binding of RAF and RAFK dissociation of RAF_RAFK phosphorylation of RAF on scaffold binding of RAF and RAFK
dissociation of RAF_RAFK phosphorylation of RAF on scaffold binding of RAF and RAFK dissociation of RAF_RAFK
phosphorylation of RAF on scaffold binding of RAF and RAFK dissociation of RAF_RAFK phosphorylation of RAF on scaffold
binding of RAF and RAFK dissociation of RAF_RAFK phosphorylation of RAF on scaffold binding of RAF and RAFK
dissociation of RAF_RAFK phosphorylation of RAF on scaffold binding of RAF and RAFK dissociation of RAF_RAFK
phosphorylation of RAF on scaffold binding of RAF and RAFK dissociation of RAF_RAFK phosphorylation of RAF on scaffold
Physical entities
Compartments Species
Cytoplasm MAPK phosphatase MEK phosphatase RAF kinase
RAF phosphatase MAPK MAPK-P
MAPK-PP MEK MEK-P
MEK-PP RAF RAF-P
MAPK_MEK-PP MAPK-P_MEK-PP MEK_RAF-P
MEK-P_RAF-P MAPK-P_MAPKPase MAPK-PP_MAPKPase
MEK-P_MEKPase MEK-PP_MEKPase RAF_RAFK
RAF-P_RAFPase Scaffold Scaffold_RAF
Scaffold_RAF-P Scaffold_MEK Scaffold_MEK_RAF
Scaffold_MEK_RAF-P Scaffold_MEK-P Scaffold_MEK-P_RAF
Scaffold_MEK-P_RAF-P Scaffold_MEK-PP Scaffold_MEK-PP_RAF
Scaffold_MEK-PP_RAF-P Scaffold_MAPK Scaffold_MAPK_RAF
Scaffold_MAPK_RAF-P Scaffold_MAPK_MEK Scaffold_MAPK_MEK_RAF
Scaffold_MAPK_MEK_RAF-P Scaffold_MAPK_MEK-P Scaffold_MAPK_MEK-P_RAF
Scaffold_MAPK_MEK-P_RAF-P Scaffold_MAPK_MEK-PP Scaffold_MAPK_MEK-PP_RAF
Scaffold_MAPK_MEK-PP_RAF-P Scaffold_MAPK-P Scaffold_MAPK-P_RAF
Scaffold_MAPK-P_RAF-P Scaffold_MAPK-P_MEK Scaffold_MAPK-P_MEK_RAF
Scaffold_MAPK-P_MEK_RAF-P Scaffold_MAPK-P_MEK-P Scaffold_MAPK-P_MEK-P_RAF
Scaffold_MAPK-P_MEK-P_RAF-P Scaffold_MAPK-P_MEK-PP Scaffold_MAPK-P_MEK-PP_RAF
Scaffold_MAPK-P_MEK-PP_RAF-P Scaffold_MAPK-PP Scaffold_MAPK-PP_RAF
Scaffold_MAPK-PP_RAF-P Scaffold_MAPK-PP_MEK Scaffold_MAPK-PP_MEK_RAF
Scaffold_MAPK-PP_MEK_RAF-P Scaffold_MAPK-PP_MEK-P Scaffold_MAPK-PP_MEK-P_RAF
Scaffold_MAPK-PP_MEK-P_RAF-P Scaffold_MAPK-PP_MEK-PP Scaffold_MAPK-PP_MEK-PP_RAF
Scaffold_MAPK-PP_MEK-PP_RAF-P Scaffold_RAF Scaffold_MEK_RAF
Scaffold_MEK-P_RAF Scaffold_MEK-PP_RAF Scaffold_MAPK_RAF
Scaffold_MAPK_MEK_RAF Scaffold_MAPK_MEK-P_RAF Scaffold_MAPK_MEK-PP_RAF
Scaffold_MAPK-P_RAF Scaffold_MAPK-P_MEK_RAF Scaffold_MAPK-P_MEK-P_RAF
Scaffold_MAPK-P_MEK-PP_RAF Scaffold_MAPK-PP_RAF Scaffold_MAPK-PP_MEK_RAF
Scaffold_MAPK-PP_MEK-P_RAF Scaffold_MAPK-PP_MEK-PP_RAF  
Reactions (300)
 
 binding of RAF and RAFK [RAF kinase] + [RAF] → [RAF_RAFK];  
 
 dissociation of RAF_RAFK [RAF_RAFK] → [RAF kinase] + [RAF];  
 
 phosphorylation of RAF [RAF_RAFK] → [RAF kinase] + [RAF-P];  
 
 binding of RAF-P and RAF phosphatase [RAF phosphatase] + [RAF-P] → [RAF-P_RAFPase];  
 
 dissociation of RAF-P_RAFPase [RAF-P_RAFPase] → [RAF phosphatase] + [RAF-P];  
 
 dephosphorylation of RAF-P [RAF-P_RAFPase] → [RAF phosphatase] + [RAF];  
 
 binding of MEK and RAF-P [MEK] + [RAF-P] → [MEK_RAF-P];  
 
 dissociation of MEK_RAF-P [MEK_RAF-P] → [MEK] + [RAF-P];  
 
 phosphorylation of MEK [MEK_RAF-P] → [MEK-P] + [RAF-P];  
 
 binding of MEK-P and MEK phosphatase [MEK phosphatase] + [MEK-P] → [MEK-P_MEKPase];  
 
 dissociation of MEK-P_MEKPase [MEK-P_MEKPase] → [MEK phosphatase] + [MEK-P];  
 
 dephosphorylation of MEK-P [MEK-P_MEKPase] → [MEK phosphatase] + [MEK];  
 
 binding of MEK-P and RAF-P [MEK-P] + [RAF-P] → [MEK-P_RAF-P];  
 
 dissociation of MEK-P_RAF-P [MEK-P_RAF-P] → [MEK-P] + [RAF-P];  
 
 phosphorylation of MEK-P [MEK-P_RAF-P] → [MEK-PP] + [RAF-P];  
 
 binding of MEK-PP and MEK phosphatase [MEK phosphatase] + [MEK-PP] → [MEK-PP_MEKPase];  
 
 dissociation of MEK-PP_MEKPase [MEK-PP_MEKPase] → [MEK phosphatase] + [MEK-PP];  
 
 dephosphorylation of MEK-PP [MEK-PP_MEKPase] → [MEK phosphatase] + [MEK-P];  
 
 binding of MAPK and MEK-PP [MAPK] + [MEK-PP] → [MAPK_MEK-PP];  
 
 dissociation of MAPK_MEK-PP [MAPK_MEK-PP] → [MAPK] + [MEK-PP];  
 
 phosphorylation of MAPK [MAPK_MEK-PP] → [MAPK-P] + [MEK-PP];  
 
 binding of MAPK-P and MAPK phosphatase [MAPK phosphatase] + [MAPK-P] → [MAPK-P_MAPKPase];  
 
 dissociation of MAPK-P_MAPKPase [MAPK-P_MAPKPase] → [MAPK phosphatase] + [MAPK-P];  
 
 dephosphorylation of MAPK-P [MAPK-P_MAPKPase] → [MAPK phosphatase] + [MAPK];  
 
 binding of MAPK-P and MEK-PP [MAPK-P] + [MEK-PP] → [MAPK-P_MEK-PP];  
 
 dissociation of MAPK-P_MEK-PP [MAPK-P_MEK-PP] → [MAPK-P] + [MEK-PP];  
 
 phosphorylation of MAPK-P [MAPK-P_MEK-PP] → [MAPK-PP] + [MEK-PP];  
 
 binding of MAPK-PP and MAPK phosphatase [MAPK phosphatase] + [MAPK-PP] → [MAPK-PP_MAPKPase];  
 
 dissociation of MAPK-PP_MAPKPase [MAPK-PP_MAPKPase] → [MAPK phosphatase] + [MAPK-PP];  
 
 dephosphorylation of MAPK-PP [MAPK-PP_MAPKPase] → [MAPK phosphatase] + [MAPK-P];  
 
 binding of MAPK on scaffold [MAPK] + [Scaffold] → [Scaffold_MAPK];  
 
 dissociation of MAPK from scaffold [Scaffold_MAPK] → [MAPK] + [Scaffold];  
 
 binding of MAPK on scaffold [MAPK] + [Scaffold_RAF] → [Scaffold_MAPK_RAF];  
 
 dissociation of MAPK from scaffold [Scaffold_MAPK_RAF] → [MAPK] + [Scaffold_RAF];  
 
 binding of MAPK on scaffold [MAPK] + [Scaffold_RAF-P] → [Scaffold_MAPK_RAF-P];  
 
 dissociation of MAPK from scaffold [Scaffold_MAPK_RAF-P] → [MAPK] + [Scaffold_RAF-P];  
 
 binding of MAPK on scaffold [MAPK] + [Scaffold_MEK] → [Scaffold_MAPK_MEK];  
 
 dissociation of MAPK from scaffold [Scaffold_MAPK_MEK] → [MAPK] + [Scaffold_MEK];  
 
 binding of MAPK on scaffold [MAPK] + [Scaffold_MEK_RAF] → [Scaffold_MAPK_MEK_RAF];  
 
 dissociation of MAPK from scaffold [Scaffold_MAPK_MEK_RAF] → [MAPK] + [Scaffold_MEK_RAF];  
 
 binding of MAPK on scaffold [MAPK] + [Scaffold_MEK_RAF-P] → [Scaffold_MAPK_MEK_RAF-P];  
 
 dissociation of MAPK from scaffold [Scaffold_MAPK_MEK_RAF-P] → [MAPK] + [Scaffold_MEK_RAF-P];  
 
 binding of MAPK on scaffold [MAPK] + [Scaffold_MEK-P] → [Scaffold_MAPK_MEK-P];  
 
 dissociation of MAPK from scaffold [Scaffold_MAPK_MEK-P] → [MAPK] + [Scaffold_MEK-P];  
 
 binding of MAPK on scaffold [MAPK] + [Scaffold_MEK-P_RAF] → [Scaffold_MAPK_MEK-P_RAF];  
 
 dissociation of MAPK from scaffold [Scaffold_MAPK_MEK-P_RAF] → [MAPK] + [Scaffold_MEK-P_RAF];  
 
 binding of MAPK on scaffold [MAPK] + [Scaffold_MEK-P_RAF-P] → [Scaffold_MAPK_MEK-P_RAF-P];  
 
 dissociation of MAPK from scaffold [Scaffold_MAPK_MEK-P_RAF-P] → [MAPK] + [Scaffold_MEK-P_RAF-P];  
 
 binding of MAPK on scaffold [MAPK] + [Scaffold_MEK-PP] → [Scaffold_MAPK_MEK-PP];  
 
 dissociation of MAPK from scaffold [Scaffold_MAPK_MEK-PP] → [MAPK] + [Scaffold_MEK-PP];  
 
 binding of MAPK on scaffold [MAPK] + [Scaffold_MEK-PP_RAF] → [Scaffold_MAPK_MEK-PP_RAF];  
 
 dissociation of MAPK from scaffold [Scaffold_MAPK_MEK-PP_RAF] → [MAPK] + [Scaffold_MEK-PP_RAF];  
 
 binding of MAPK on scaffold [MAPK] + [Scaffold_MEK-PP_RAF-P] → [Scaffold_MAPK_MEK-PP_RAF-P];  
 
 dissociation of MAPK from scaffold [Scaffold_MAPK_MEK-PP_RAF-P] → [MAPK] + [Scaffold_MEK-PP_RAF-P];  
 
 binding of MAPK-P on scaffold [MAPK-P] + [Scaffold] → [Scaffold_MAPK-P];  
 
 dissociation of MAPK-P from scaffold [Scaffold_MAPK-P] → [MAPK-P] + [Scaffold];  
 
 binding of MAPK-P on scaffold [MAPK-P] + [Scaffold_RAF] → [Scaffold_MAPK-P_RAF];  
 
 dissociation of MAPK-P from scaffold [Scaffold_MAPK-P_RAF] → [MAPK-P] + [Scaffold_RAF];  
 
 binding of MAPK-P on scaffold [MAPK-P] + [Scaffold_RAF-P] → [Scaffold_MAPK-P_RAF-P];  
 
 dissociation of MAPK-P from scaffold [Scaffold_MAPK-P_RAF-P] → [MAPK-P] + [Scaffold_RAF-P];  
 
 binding of MAPK-P on scaffold [MAPK-P] + [Scaffold_MEK] → [Scaffold_MAPK-P_MEK];  
 
 dissociation of MAPK-P from scaffold [Scaffold_MAPK-P_MEK] → [MAPK-P] + [Scaffold_MEK];  
 
 binding of MAPK-P on scaffold [MAPK-P] + [Scaffold_MEK_RAF] → [Scaffold_MAPK-P_MEK_RAF];  
 
 dissociation of MAPK-P from scaffold [Scaffold_MAPK-P_MEK_RAF] → [MAPK-P] + [Scaffold_MEK_RAF];  
 
 binding of MAPK-P on scaffold [MAPK-P] + [Scaffold_MEK_RAF-P] → [Scaffold_MAPK-P_MEK_RAF-P];  
 
 dissociation of MAPK-P from scaffold [Scaffold_MAPK-P_MEK_RAF-P] → [MAPK-P] + [Scaffold_MEK_RAF-P];  
 
 binding of MAPK-P on scaffold [MAPK-P] + [Scaffold_MEK-P] → [Scaffold_MAPK-P_MEK-P];  
 
 dissociation of MAPK-P from scaffold [Scaffold_MAPK-P_MEK-P] → [MAPK-P] + [Scaffold_MEK-P];  
 
 binding of MAPK-P on scaffold [MAPK-P] + [Scaffold_MEK-P_RAF] → [Scaffold_MAPK-P_MEK-P_RAF];  
 
 dissociation of MAPK-P from scaffold [Scaffold_MAPK-P_MEK-P_RAF] → [MAPK-P] + [Scaffold_MEK-P_RAF];  
 
 binding of MAPK-P on scaffold [MAPK-P] + [Scaffold_MEK-P_RAF-P] → [Scaffold_MAPK-P_MEK-P_RAF-P];  
 
 dissociation of MAPK-P from scaffold [Scaffold_MAPK-P_MEK-P_RAF-P] → [MAPK-P] + [Scaffold_MEK-P_RAF-P];  
 
 binding of MAPK-P on scaffold [MAPK-P] + [Scaffold_MEK-PP] → [Scaffold_MAPK-P_MEK-PP];  
 
 dissociation of MAPK-P from scaffold [Scaffold_MAPK-P_MEK-PP] → [MAPK-P] + [Scaffold_MEK-PP];  
 
 binding of MAPK-P on scaffold [MAPK-P] + [Scaffold_MEK-PP_RAF] → [Scaffold_MAPK-P_MEK-PP_RAF];  
 
 dissociation of MAPK-P from scaffold [Scaffold_MAPK-P_MEK-PP_RAF] → [MAPK-P] + [Scaffold_MEK-PP_RAF];  
 
 binding of MAPK-P on scaffold [MAPK-P] + [Scaffold_MEK-PP_RAF-P] → [Scaffold_MAPK-P_MEK-PP_RAF-P];  
 
 dissociation of MAPK-P from scaffold [Scaffold_MAPK-P_MEK-PP_RAF-P] → [MAPK-P] + [Scaffold_MEK-PP_RAF-P];  
 
 binding of MAPK-PP on scaffold [MAPK-PP] + [Scaffold] → [Scaffold_MAPK-PP];  
 
 dissociation of MAPK-PP from scaffold [Scaffold_MAPK-PP] → [MAPK-PP] + [Scaffold];  
 
 binding of MAPK-PP on scaffold [MAPK-PP] + [Scaffold_RAF] → [Scaffold_MAPK-PP_RAF];  
 
 dissociation of MAPK-PP from scaffold [Scaffold_MAPK-PP_RAF] → [MAPK-PP] + [Scaffold_RAF];  
 
 binding of MAPK-PP on scaffold [MAPK-PP] + [Scaffold_RAF-P] → [Scaffold_MAPK-PP_RAF-P];  
 
 dissociation of MAPK-PP from scaffold [Scaffold_MAPK-PP_RAF-P] → [MAPK-PP] + [Scaffold_RAF-P];  
 
 binding of MAPK-PP on scaffold [MAPK-PP] + [Scaffold_MEK] → [Scaffold_MAPK-PP_MEK];  
 
 dissociation of MAPK-PP from scaffold [Scaffold_MAPK-PP_MEK] → [MAPK-PP] + [Scaffold_MEK];  
 
 binding of MAPK-PP on scaffold [MAPK-PP] + [Scaffold_MEK_RAF] → [Scaffold_MAPK-PP_MEK_RAF];  
 
 dissociation of MAPK-PP from scaffold [Scaffold_MAPK-PP_MEK_RAF] → [MAPK-PP] + [Scaffold_MEK_RAF];  
 
 binding of MAPK-PP on scaffold [MAPK-PP] + [Scaffold_MEK_RAF-P] → [Scaffold_MAPK-PP_MEK_RAF-P];  
 
 dissociation of MAPK-PP from scaffold [Scaffold_MAPK-PP_MEK_RAF-P] → [MAPK-PP] + [Scaffold_MEK_RAF-P];  
 
 binding of MAPK-PP on scaffold [MAPK-PP] + [Scaffold_MEK-P] → [Scaffold_MAPK-PP_MEK-P];  
 
 dissociation of MAPK-PP from scaffold [Scaffold_MAPK-PP_MEK-P] → [MAPK-PP] + [Scaffold_MEK-P];  
 
 binding of MAPK-PP on scaffold [MAPK-PP] + [Scaffold_MEK-P_RAF] → [Scaffold_MAPK-PP_MEK-P_RAF];  
 
 dissociation of MAPK-PP from scaffold [Scaffold_MAPK-PP_MEK-P_RAF] → [MAPK-PP] + [Scaffold_MEK-P_RAF];  
 
 binding of MAPK-PP on scaffold [MAPK-PP] + [Scaffold_MEK-P_RAF-P] → [Scaffold_MAPK-PP_MEK-P_RAF-P];  
 
 dissociation of MAPK-PP from scaffold [Scaffold_MAPK-PP_MEK-P_RAF-P] → [MAPK-PP] + [Scaffold_MEK-P_RAF-P];  
 
 binding of MAPK-PP on scaffold [MAPK-PP] + [Scaffold_MEK-PP] → [Scaffold_MAPK-PP_MEK-PP];  
 
 dissociation of MAPK-PP from scaffold [Scaffold_MAPK-PP_MEK-PP] → [MAPK-PP] + [Scaffold_MEK-PP];  
 
 binding of MAPK-PP on scaffold [MAPK-PP] + [Scaffold_MEK-PP_RAF] → [Scaffold_MAPK-PP_MEK-PP_RAF];  
 
 dissociation of MAPK-PP from scaffold [Scaffold_MAPK-PP_MEK-PP_RAF] → [MAPK-PP] + [Scaffold_MEK-PP_RAF];  
 
 binding of MAPK-PP on scaffold [MAPK-PP] + [Scaffold_MEK-PP_RAF-P] → [Scaffold_MAPK-PP_MEK-PP_RAF-P];  
 
 dissociation of MAPK-PP from scaffold [Scaffold_MAPK-PP_MEK-PP_RAF-P] → [MAPK-PP] + [Scaffold_MEK-PP_RAF-P];  
 
 binding of MEK on scaffold [MEK] + [Scaffold] → [Scaffold_MEK];  
 
 dissociation of MEK from scaffold [Scaffold_MEK] → [MEK] + [Scaffold];  
 
 binding of MEK on scaffold [MEK] + [Scaffold_RAF] → [Scaffold_MEK_RAF];  
 
 dissociation of MEK from scaffold [Scaffold_MEK_RAF] → [MEK] + [Scaffold_RAF];  
 
 binding of MEK on scaffold [MEK] + [Scaffold_RAF-P] → [Scaffold_MEK_RAF-P];  
 
 dissociation of MEK from scaffold [Scaffold_MEK_RAF-P] → [MEK] + [Scaffold_RAF-P];  
 
 binding of MEK-P on scaffold [MEK-P] + [Scaffold] → [Scaffold_MEK-P];  
 
 dissociation of MEK-P from scaffold [Scaffold_MEK-P] → [MEK-P] + [Scaffold];  
 
 binding of MEK-P on scaffold [MEK-P] + [Scaffold_RAF] → [Scaffold_MEK-P_RAF];  
 
 dissociation of MEK-P from scaffold [Scaffold_MEK-P_RAF] → [MEK-P] + [Scaffold_RAF];  
 
 binding of MEK-P on scaffold [MEK-P] + [Scaffold_RAF-P] → [Scaffold_MEK-P_RAF-P];  
 
 dissociation of MEK-P from scaffold [Scaffold_MEK-P_RAF-P] → [MEK-P] + [Scaffold_RAF-P];  
 
 binding of MEK-PP on scaffold [MEK-PP] + [Scaffold] → [Scaffold_MEK-PP];  
 
 dissociation of MEK-PP from scaffold [Scaffold_MEK-PP] → [MEK-PP] + [Scaffold];  
 
 binding of MEK-PP on scaffold [MEK-PP] + [Scaffold_RAF] → [Scaffold_MEK-PP_RAF];  
 
 dissociation of MEK-PP from scaffold [Scaffold_MEK-PP_RAF] → [MEK-PP] + [Scaffold_RAF];  
 
 binding of MEK-PP on scaffold [MEK-PP] + [Scaffold_RAF-P] → [Scaffold_MEK-PP_RAF-P];  
 
 dissociation of MEK-PP from scaffold [Scaffold_MEK-PP_RAF-P] → [MEK-PP] + [Scaffold_RAF-P];  
 
 binding of MEK on scaffold [MEK] + [Scaffold_MAPK] → [Scaffold_MAPK_MEK];  
 
 dissociation of MEK from scaffold [Scaffold_MAPK_MEK] → [MEK] + [Scaffold_MAPK];  
 
 binding of MEK on scaffold [MEK] + [Scaffold_MAPK_RAF] → [Scaffold_MAPK_MEK_RAF];  
 
 dissociation of MEK from scaffold [Scaffold_MAPK_MEK_RAF] → [MEK] + [Scaffold_MAPK_RAF];  
 
 binding of MEK on scaffold [MEK] + [Scaffold_MAPK_RAF-P] → [Scaffold_MAPK_MEK_RAF-P];  
 
 dissociation of MEK from scaffold [Scaffold_MAPK_MEK_RAF-P] → [MEK] + [Scaffold_MAPK_RAF-P];  
 
 binding of MEK-P on scaffold [MEK-P] + [Scaffold_MAPK] → [Scaffold_MAPK_MEK-P];  
 
 dissociation of MEK-P from scaffold [Scaffold_MAPK_MEK-P] → [MEK-P] + [Scaffold_MAPK];  
 
 binding of MEK-P on scaffold [MEK-P] + [Scaffold_MAPK_RAF] → [Scaffold_MAPK_MEK-P_RAF];  
 
 dissociation of MEK-P from scaffold [Scaffold_MAPK_MEK-P_RAF] → [MEK-P] + [Scaffold_MAPK_RAF];  
 
 binding of MEK-P on scaffold [MEK-P] + [Scaffold_MAPK_RAF-P] → [Scaffold_MAPK_MEK-P_RAF-P];  
 
 dissociation of MEK-P from scaffold [Scaffold_MAPK_MEK-P_RAF-P] → [MEK-P] + [Scaffold_MAPK_RAF-P];  
 
 binding of MEK-PP on scaffold [MEK-PP] + [Scaffold_MAPK] → [Scaffold_MAPK_MEK-PP];  
 
 dissociation of MEK-PP from scaffold [Scaffold_MAPK_MEK-PP] → [MEK-PP] + [Scaffold_MAPK];  
 
 binding of MEK-PP on scaffold [MEK-PP] + [Scaffold_MAPK_RAF] → [Scaffold_MAPK_MEK-PP_RAF];  
 
 dissociation of MEK-PP from scaffold [Scaffold_MAPK_MEK-PP_RAF] → [MEK-PP] + [Scaffold_MAPK_RAF];  
 
 binding of MEK-PP on scaffold [MEK-PP] + [Scaffold_MAPK_RAF-P] → [Scaffold_MAPK_MEK-PP_RAF-P];  
 
 dissociation of MEK-PP from scaffold [Scaffold_MAPK_MEK-PP_RAF-P] → [MEK-PP] + [Scaffold_MAPK_RAF-P];  
 
 binding of MEK on scaffold [MEK] + [Scaffold_MAPK-P] → [Scaffold_MAPK-P_MEK];  
 
 dissociation of MEK from scaffold [Scaffold_MAPK-P_MEK] → [MEK] + [Scaffold_MAPK-P];  
 
 binding of MEK on scaffold [MEK] + [Scaffold_MAPK-P_RAF] → [Scaffold_MAPK-P_MEK_RAF];  
 
 dissociation of MEK from scaffold [Scaffold_MAPK-P_MEK_RAF] → [MEK] + [Scaffold_MAPK-P_RAF];  
 
 binding of MEK on scaffold [MEK] + [Scaffold_MAPK-P_RAF-P] → [Scaffold_MAPK-P_MEK_RAF-P];  
 
 dissociation of MEK from scaffold [Scaffold_MAPK-P_MEK_RAF-P] → [MEK] + [Scaffold_MAPK-P_RAF-P];  
 
 binding of MEK-P on scaffold [MEK-P] + [Scaffold_MAPK-P] → [Scaffold_MAPK-P_MEK-P];  
 
 dissociation of MEK-P from scaffold [Scaffold_MAPK-P_MEK-P] → [MEK-P] + [Scaffold_MAPK-P];  
 
 binding of MEK-P on scaffold [MEK-P] + [Scaffold_MAPK-P_RAF] → [Scaffold_MAPK-P_MEK-P_RAF];  
 
 dissociation of MEK-P from scaffold [Scaffold_MAPK-P_MEK-P_RAF] → [MEK-P] + [Scaffold_MAPK-P_RAF];  
 
 binding of MEK-P on scaffold [MEK-P] + [Scaffold_MAPK-P_RAF-P] → [Scaffold_MAPK-P_MEK-P_RAF-P];  
 
 dissociation of MEK-P from scaffold [Scaffold_MAPK-P_MEK-P_RAF-P] → [MEK-P] + [Scaffold_MAPK-P_RAF-P];  
 
 binding of MEK-PP on scaffold [MEK-PP] + [Scaffold_MAPK-P] → [Scaffold_MAPK-P_MEK-PP];  
 
 dissociation of MEK-PP from scaffold [Scaffold_MAPK-P_MEK-PP] → [MEK-PP] + [Scaffold_MAPK-P];  
 
 binding of MEK-PP on scaffold [MEK-PP] + [Scaffold_MAPK-P_RAF] → [Scaffold_MAPK-P_MEK-PP_RAF];  
 
 dissociation of MEK-PP from scaffold [Scaffold_MAPK-P_MEK-PP_RAF] → [MEK-PP] + [Scaffold_MAPK-P_RAF];  
 
 binding of MEK-PP on scaffold [MEK-PP] + [Scaffold_MAPK-P_RAF-P] → [Scaffold_MAPK-P_MEK-PP_RAF-P];  
 
 dissociation of MEK-PP from scaffold [Scaffold_MAPK-P_MEK-PP_RAF-P] → [MEK-PP] + [Scaffold_MAPK-P_RAF-P];  
 
 binding of MEK on scaffold [MEK] + [Scaffold_MAPK-PP] → [Scaffold_MAPK-PP_MEK];  
 
 dissociation of MEK from scaffold [Scaffold_MAPK-PP_MEK] → [MEK] + [Scaffold_MAPK-PP];  
 
 binding of MEK on scaffold [MEK] + [Scaffold_MAPK-PP_RAF] → [Scaffold_MAPK-PP_MEK_RAF];  
 
 dissociation of MEK from scaffold [Scaffold_MAPK-PP_MEK_RAF] → [MEK] + [Scaffold_MAPK-PP_RAF];  
 
 binding of MEK on scaffold [MEK] + [Scaffold_MAPK-PP_RAF-P] → [Scaffold_MAPK-PP_MEK_RAF-P];  
 
 dissociation of MEK from scaffold [Scaffold_MAPK-PP_MEK_RAF-P] → [MEK] + [Scaffold_MAPK-PP_RAF-P];  
 
 binding of MEK-P on scaffold [MEK-P] + [Scaffold_MAPK-PP] → [Scaffold_MAPK-PP_MEK-P];  
 
 dissociation of MEK-P from scaffold [Scaffold_MAPK-PP_MEK-P] → [MEK-P] + [Scaffold_MAPK-PP];  
 
 binding of MEK-P on scaffold [MEK-P] + [Scaffold_MAPK-PP_RAF] → [Scaffold_MAPK-PP_MEK-P_RAF];  
 
 dissociation of MEK-P from scaffold [Scaffold_MAPK-PP_MEK-P_RAF] → [MEK-P] + [Scaffold_MAPK-PP_RAF];  
 
 binding of MEK-P on scaffold [MEK-P] + [Scaffold_MAPK-PP_RAF-P] → [Scaffold_MAPK-PP_MEK-P_RAF-P];  
 
 dissociation of MEK-P from scaffold [Scaffold_MAPK-PP_MEK-P_RAF-P] → [MEK-P] + [Scaffold_MAPK-PP_RAF-P];  
 
 binding of MEK-PP on scaffold [MEK-PP] + [Scaffold_MAPK-PP] → [Scaffold_MAPK-PP_MEK-PP];  
 
 dissociation of MEK-PP from scaffold [Scaffold_MAPK-PP_MEK-PP] → [MEK-PP] + [Scaffold_MAPK-PP];  
 
 binding of MEK-PP on scaffold [MEK-PP] + [Scaffold_MAPK-PP_RAF] → [Scaffold_MAPK-PP_MEK-PP_RAF];  
 
 dissociation of MEK-PP from scaffold [Scaffold_MAPK-PP_MEK-PP_RAF] → [MEK-PP] + [Scaffold_MAPK-PP_RAF];  
 
 binding of MEK-PP on scaffold [MEK-PP] + [Scaffold_MAPK-PP_RAF-P] → [Scaffold_MAPK-PP_MEK-PP_RAF-P];  
 
 dissociation of MEK-PP from scaffold [Scaffold_MAPK-PP_MEK-PP_RAF-P] → [MEK-PP] + [Scaffold_MAPK-PP_RAF-P];  
 
 binding of RAF on scaffold [RAF] + [Scaffold] → [Scaffold_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_RAF] → [RAF] + [Scaffold];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold] → [Scaffold_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_RAF-P] → [RAF-P] + [Scaffold];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MEK] → [Scaffold_MEK_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MEK_RAF] → [RAF] + [Scaffold_MEK];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MEK] → [Scaffold_MEK_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MEK_RAF-P] → [RAF-P] + [Scaffold_MEK];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MEK-P] → [Scaffold_MEK-P_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MEK-P_RAF] → [RAF] + [Scaffold_MEK-P];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MEK-P] → [Scaffold_MEK-P_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MEK-P_RAF-P] → [RAF-P] + [Scaffold_MEK-P];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MEK-PP] → [Scaffold_MEK-PP_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MEK-PP_RAF] → [RAF] + [Scaffold_MEK-PP];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MEK-PP] → [Scaffold_MEK-PP_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MEK-PP_RAF-P] → [RAF-P] + [Scaffold_MEK-PP];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MAPK] → [Scaffold_MAPK_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK_RAF] → [RAF] + [Scaffold_MAPK];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MAPK] → [Scaffold_MAPK_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MAPK_RAF-P] → [RAF-P] + [Scaffold_MAPK];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MAPK_MEK] → [Scaffold_MAPK_MEK_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK_MEK_RAF] → [RAF] + [Scaffold_MAPK_MEK];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MAPK_MEK] → [Scaffold_MAPK_MEK_RAF-P];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK_MEK_RAF-P] → [RAF-P] + [Scaffold_MAPK_MEK];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MAPK_MEK-P] → [Scaffold_MAPK_MEK-P_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK_MEK-P_RAF] → [RAF] + [Scaffold_MAPK_MEK-P];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MAPK_MEK-P] → [Scaffold_MAPK_MEK-P_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MAPK_MEK-P_RAF-P] → [RAF-P] + [Scaffold_MAPK_MEK-P];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MAPK_MEK-PP] → [Scaffold_MAPK_MEK-PP_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK_MEK-PP_RAF] → [RAF] + [Scaffold_MAPK_MEK-PP];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MAPK_MEK-PP] → [Scaffold_MAPK_MEK-PP_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MAPK_MEK-PP_RAF-P] → [RAF-P] + [Scaffold_MAPK_MEK-PP];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MAPK-P] → [Scaffold_MAPK-P_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK-P_RAF] → [RAF] + [Scaffold_MAPK-P];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MAPK-P] → [Scaffold_MAPK-P_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MAPK-P_RAF-P] → [RAF-P] + [Scaffold_MAPK-P];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MAPK-P_MEK] → [Scaffold_MAPK-P_MEK_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK-P_MEK_RAF] → [RAF] + [Scaffold_MAPK-P_MEK];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MAPK-P_MEK] → [Scaffold_MAPK-P_MEK_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MAPK-P_MEK_RAF-P] → [RAF-P] + [Scaffold_MAPK-P_MEK];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MAPK-P_MEK-P] → [Scaffold_MAPK-P_MEK-P_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK-P_MEK-P_RAF] → [RAF] + [Scaffold_MAPK-P_MEK-P];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MAPK-P_MEK-P] → [Scaffold_MAPK-P_MEK-P_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MAPK-P_MEK-P_RAF-P] → [RAF-P] + [Scaffold_MAPK-P_MEK-P];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MAPK-P_MEK-PP] → [Scaffold_MAPK-P_MEK-PP_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK-P_MEK-PP_RAF] → [RAF] + [Scaffold_MAPK-P_MEK-PP];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MAPK-P_MEK-PP] → [Scaffold_MAPK-P_MEK-PP_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MAPK-P_MEK-PP_RAF-P] → [RAF-P] + [Scaffold_MAPK-P_MEK-PP];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MAPK-PP] → [Scaffold_MAPK-PP_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK-PP_RAF] → [RAF] + [Scaffold_MAPK-PP];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MAPK-PP] → [Scaffold_MAPK-PP_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MAPK-PP_RAF-P] → [RAF-P] + [Scaffold_MAPK-PP];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MAPK-PP_MEK] → [Scaffold_MAPK-PP_MEK_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK-PP_MEK_RAF] → [RAF] + [Scaffold_MAPK-PP_MEK];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MAPK-PP_MEK] → [Scaffold_MAPK-PP_MEK_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MAPK-PP_MEK_RAF-P] → [RAF-P] + [Scaffold_MAPK-PP_MEK];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MAPK-PP_MEK-P] → [Scaffold_MAPK-PP_MEK-P_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK-PP_MEK-P_RAF] → [RAF] + [Scaffold_MAPK-PP_MEK-P];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MAPK-PP_MEK-P] → [Scaffold_MAPK-PP_MEK-P_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MAPK-PP_MEK-P_RAF-P] → [RAF-P] + [Scaffold_MAPK-PP_MEK-P];  
 
 binding of RAF on scaffold [RAF] + [Scaffold_MAPK-PP_MEK-PP] → [Scaffold_MAPK-PP_MEK-PP_RAF];  
 
 dissociation of RAF from scaffold [Scaffold_MAPK-PP_MEK-PP_RAF] → [RAF] + [Scaffold_MAPK-PP_MEK-PP];  
 
 binding of RAF-P on scaffold [RAF-P] + [Scaffold_MAPK-PP_MEK-PP] → [Scaffold_MAPK-PP_MEK-PP_RAF-P];  
 
 dissociation of RAF-P from scaffold [Scaffold_MAPK-PP_MEK-PP_RAF-P] → [RAF-P] + [Scaffold_MAPK-PP_MEK-PP];  
 
 phosphorylation of MAPK on scaffold [Scaffold_MAPK_MEK-PP] → [Scaffold_MAPK-P_MEK-PP];  
 
 phosphorylation of MAPK on scaffold [Scaffold_MAPK_MEK-PP_RAF] → [Scaffold_MAPK-P_MEK-PP_RAF];  
 
 phosphorylation of MAPK on scaffold [Scaffold_MAPK_MEK-PP_RAF-P] → [Scaffold_MAPK-P_MEK-PP_RAF-P];  
 
 phosphorylation of MAPK-P on scaffold [Scaffold_MAPK-P_MEK-PP] → [Scaffold_MAPK-PP_MEK-PP];  
 
 phosphorylation of MAPK-P on scaffold [Scaffold_MAPK-P_MEK-PP_RAF] → [Scaffold_MAPK-PP_MEK-PP_RAF];  
 
 phosphorylation of MAPK-P on scaffold [Scaffold_MAPK-P_MEK-PP_RAF-P] → [Scaffold_MAPK-PP_MEK-PP_RAF-P];  
 
 phosphorylation of MEK on scaffold [Scaffold_MEK_RAF-P] → [Scaffold_MEK-P_RAF-P];  
 
 phosphorylation of MEK-P on scaffold [Scaffold_MEK-P_RAF-P] → [Scaffold_MEK-PP_RAF-P];  
 
 phosphorylation of MEK on scaffold [Scaffold_MAPK_MEK_RAF-P] → [Scaffold_MAPK_MEK-P_RAF-P];  
 
 phosphorylation of MEK-P on scaffold [Scaffold_MAPK_MEK-P_RAF-P] → [Scaffold_MAPK_MEK-PP_RAF-P];  
 
 phosphorylation of MEK on scaffold [Scaffold_MAPK-P_MEK_RAF-P] → [Scaffold_MAPK-P_MEK-P_RAF-P];  
 
 phosphorylation of MEK-P on scaffold [Scaffold_MAPK-P_MEK-P_RAF-P] → [Scaffold_MAPK-P_MEK-PP_RAF-P];  
 
 phosphorylation of MEK on scaffold [Scaffold_MAPK-PP_MEK_RAF-P] → [Scaffold_MAPK-PP_MEK-P_RAF-P];  
 
 phosphorylation of MEK-P on scaffold [Scaffold_MAPK-PP_MEK-P_RAF-P] → [Scaffold_MAPK-PP_MEK-PP_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_RAF] → [Scaffold_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_RAF] → [RAF kinase] + [Scaffold_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_RAF] → [RAF kinase] + [Scaffold_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MEK_RAF] → [Scaffold_MEK_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MEK_RAF] → [RAF kinase] + [Scaffold_MEK_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MEK_RAF] → [RAF kinase] + [Scaffold_MEK_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MEK-P_RAF] → [Scaffold_MEK-P_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MEK-P_RAF] → [RAF kinase] + [Scaffold_MEK-P_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MEK-P_RAF] → [RAF kinase] + [Scaffold_MEK-P_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MEK-PP_RAF] → [Scaffold_MEK-PP_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MEK-PP_RAF] → [RAF kinase] + [Scaffold_MEK-PP_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MEK-PP_RAF] → [RAF kinase] + [Scaffold_MEK-PP_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MAPK_RAF] → [Scaffold_MAPK_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MAPK_RAF] → [RAF kinase] + [Scaffold_MAPK_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MAPK_RAF] → [RAF kinase] + [Scaffold_MAPK_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MAPK_MEK_RAF] → [Scaffold_MAPK_MEK_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MAPK_MEK_RAF] → [RAF kinase] + [Scaffold_MAPK_MEK_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MAPK_MEK_RAF] → [RAF kinase] + [Scaffold_MAPK_MEK_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MAPK_MEK-P_RAF] → [Scaffold_MAPK_MEK-P_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MAPK_MEK-P_RAF] → [RAF kinase] + [Scaffold_MAPK_MEK-P_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MAPK_MEK-P_RAF] → [RAF kinase] + [Scaffold_MAPK_MEK-P_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MAPK_MEK-PP_RAF] → [Scaffold_MAPK_MEK-PP_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MAPK_MEK-PP_RAF] → [RAF kinase] + [Scaffold_MAPK_MEK-PP_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MAPK_MEK-PP_RAF] → [RAF kinase] + [Scaffold_MAPK_MEK-PP_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MAPK-P_RAF] → [Scaffold_MAPK-P_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MAPK-P_RAF] → [RAF kinase] + [Scaffold_MAPK-P_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MAPK-P_RAF] → [RAF kinase] + [Scaffold_MAPK-P_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MAPK-P_MEK_RAF] → [Scaffold_MAPK-P_MEK_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MAPK-P_MEK_RAF] → [RAF kinase] + [Scaffold_MAPK-P_MEK_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MAPK-P_MEK_RAF] → [RAF kinase] + [Scaffold_MAPK-P_MEK_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MAPK-P_MEK-P_RAF] → [Scaffold_MAPK-P_MEK-P_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MAPK-P_MEK-P_RAF] → [RAF kinase] + [Scaffold_MAPK-P_MEK-P_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MAPK-P_MEK-P_RAF] → [RAF kinase] + [Scaffold_MAPK-P_MEK-P_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MAPK-P_MEK-PP_RAF] → [Scaffold_MAPK-P_MEK-PP_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MAPK-P_MEK-PP_RAF] → [RAF kinase] + [Scaffold_MAPK-P_MEK-PP_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MAPK-P_MEK-PP_RAF] → [RAF kinase] + [Scaffold_MAPK-P_MEK-PP_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MAPK-PP_RAF] → [Scaffold_MAPK-PP_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MAPK-PP_RAF] → [RAF kinase] + [Scaffold_MAPK-PP_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MAPK-PP_RAF] → [RAF kinase] + [Scaffold_MAPK-PP_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MAPK-PP_MEK_RAF] → [Scaffold_MAPK-PP_MEK_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MAPK-PP_MEK_RAF] → [RAF kinase] + [Scaffold_MAPK-PP_MEK_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MAPK-PP_MEK_RAF] → [RAF kinase] + [Scaffold_MAPK-PP_MEK_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MAPK-PP_MEK-P_RAF] → [Scaffold_MAPK-PP_MEK-P_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MAPK-PP_MEK-P_RAF] → [RAF kinase] + [Scaffold_MAPK-PP_MEK-P_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MAPK-PP_MEK-P_RAF] → [RAF kinase] + [Scaffold_MAPK-PP_MEK-P_RAF-P];  
 
 binding of RAF and RAFK [RAF kinase] + [Scaffold_MAPK-PP_MEK-PP_RAF] → [Scaffold_MAPK-PP_MEK-PP_RAF];  
 
 dissociation of RAF_RAFK [Scaffold_MAPK-PP_MEK-PP_RAF] → [RAF kinase] + [Scaffold_MAPK-PP_MEK-PP_RAF];  
 
 phosphorylation of RAF on scaffold [Scaffold_MAPK-PP_MEK-PP_RAF] → [RAF kinase] + [Scaffold_MAPK-PP_MEK-PP_RAF-P];  
 
  Spatial dimensions: 3.0  Compartment size: 1.0
 
 MAPK phosphatase
Compartment: Cytoplasm
Initial amount: 0.3
 
   MEK phosphatase
Compartment: Cytoplasm
Initial amount: 0.2
 
 RAF kinase
Compartment: Cytoplasm
Initial amount: 0.1
 
   RAF phosphatase
Compartment: Cytoplasm
Initial amount: 0.3
 
 MAPK
Compartment: Cytoplasm
Initial amount: 0.4
 
 MAPK-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 MAPK-PP
Compartment: Cytoplasm
Initial amount: 0.0
 
 MEK
Compartment: Cytoplasm
Initial amount: 0.2
 
 MEK-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 MEK-PP
Compartment: Cytoplasm
Initial amount: 0.0
 
 RAF
Compartment: Cytoplasm
Initial amount: 0.3
 
 RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 MAPK_MEK-PP
Compartment: Cytoplasm
Initial amount: 0.0
 
 MAPK-P_MEK-PP
Compartment: Cytoplasm
Initial amount: 0.0
 
 MEK_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 MEK-P_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 MAPK-P_MAPKPase
Compartment: Cytoplasm
Initial amount: 0.0
 
 MAPK-PP_MAPKPase
Compartment: Cytoplasm
Initial amount: 0.0
 
 MEK-P_MEKPase
Compartment: Cytoplasm
Initial amount: 0.0
 
 MEK-PP_MEKPase
Compartment: Cytoplasm
Initial amount: 0.0
 
 RAF_RAFK
Compartment: Cytoplasm
Initial amount: 0.0
 
 RAF-P_RAFPase
Compartment: Cytoplasm
Initial amount: 0.0
 
   Scaffold
Compartment: Cytoplasm
Initial amount: 0.1
 
 Scaffold_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MEK
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MEK_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MEK_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MEK-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MEK-P_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MEK-P_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MEK-PP
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MEK-PP_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MEK-PP_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_MEK
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_MEK_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_MEK_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_MEK-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_MEK-P_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_MEK-P_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_MEK-PP
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_MEK-PP_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_MEK-PP_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_MEK
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_MEK_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_MEK_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_MEK-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_MEK-P_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_MEK-P_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_MEK-PP
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_MEK-PP_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_MEK-PP_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_MEK
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_MEK_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_MEK_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_MEK-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_MEK-P_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_MEK-P_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_MEK-PP
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_MEK-PP_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_MEK-PP_RAF-P
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MEK_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MEK-P_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MEK-PP_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_MEK_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_MEK-P_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK_MEK-PP_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_MEK_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_MEK-P_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-P_MEK-PP_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_MEK_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_MEK-P_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
 Scaffold_MAPK-PP_MEK-PP_RAF
Compartment: Cytoplasm
Initial amount: 0.0
 
binding of RAF and RAFK (1)
 
   a1
Value: 1.0
Constant
 
dissociation of RAF_RAFK (1)
 
   d1
Value: 0.4
Constant
 
phosphorylation of RAF (1)
 
   k1
Value: 0.1
Constant
 
binding of RAF-P and RAF phosphatase (1)
 
   a2
Value: 0.5
Constant
 
dissociation of RAF-P_RAFPase (1)
 
   d2
Value: 0.5
Constant
 
dephosphorylation of RAF-P (1)
 
   k2
Value: 0.1
Constant
 
binding of MEK and RAF-P (1)
 
   a3
Value: 3.3
Constant
 
dissociation of MEK_RAF-P (1)
 
   d3
Value: 0.42
Constant
 
phosphorylation of MEK (1)
 
   k3
Value: 0.1
Constant
 
binding of MEK-P and MEK phosphatase (1)
 
   a4
Value: 10.0
Constant
 
dissociation of MEK-P_MEKPase (1)
 
   d4
Value: 0.8
Constant
 
dephosphorylation of MEK-P (1)
 
   k4
Value: 0.1
Constant
 
binding of MEK-P and RAF-P (1)
 
   a5
Value: 3.3
Constant
 
dissociation of MEK-P_RAF-P (1)
 
   d5
Value: 0.4
Constant
 
phosphorylation of MEK-P (1)
 
   k5
Value: 0.1
Constant
 
binding of MEK-PP and MEK phosphatase (1)
 
   a6
Value: 10.0
Constant
 
dissociation of MEK-PP_MEKPase (1)
 
   d6
Value: 0.8
Constant
 
dephosphorylation of MEK-PP (1)
 
   k6
Value: 0.1
Constant
 
binding of MAPK and MEK-PP (1)
 
   a7
Value: 20.0
Constant
 
dissociation of MAPK_MEK-PP (1)
 
   d7
Value: 0.6
Constant
 
phosphorylation of MAPK (1)
 
   k7
Value: 0.1
Constant
 
binding of MAPK-P and MAPK phosphatase (1)
 
   a8
Value: 5.0
Constant
 
dissociation of MAPK-P_MAPKPase (1)
 
   d8
Value: 0.4
Constant
 
dephosphorylation of MAPK-P (1)
 
   k8
Value: 0.1
Constant
 
binding of MAPK-P and MEK-PP (1)
 
   a9
Value: 20.0
Constant
 
dissociation of MAPK-P_MEK-PP (1)
 
   d9
Value: 0.6
Constant
 
phosphorylation of MAPK-P (1)
 
   k9
Value: 0.1
Constant
 
binding of MAPK-PP and MAPK phosphatase (1)
 
   a10
Value: 5.0
Constant
 
dissociation of MAPK-PP_MAPKPase (1)
 
   d10
Value: 0.4
Constant
 
dephosphorylation of MAPK-PP (1)
 
   k10
Value: 0.1
Constant
 
binding of MAPK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MAPK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MAPK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MAPK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MAPK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MAPK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MAPK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MAPK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MAPK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MAPK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MAPK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MAPK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MAPK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MAPK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MAPK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MAPK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MAPK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MAPK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MAPK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MAPK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MAPK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MAPK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MAPK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MAPK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MAPK-P on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-P from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-P on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-P from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-P on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-P from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-P on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-P from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-P on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-P from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-P on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-P from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-P on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-P from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-P on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-P from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-P on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-P from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-P on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-P from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-P on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-P from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-P on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-P from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-PP on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-PP from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-PP on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-PP from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-PP on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-PP from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-PP on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-PP from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-PP on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-PP from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-PP on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-PP from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-PP on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-PP from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-PP on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-PP from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-PP on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-PP from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-PP on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-PP from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-PP on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-PP from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MAPK-PP on scaffold (1)
 
   kpon
Constant
 
dissociation of MAPK-PP from scaffold (1)
 
   kpoff
Value: 0.05
Constant
 
binding of MEK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MEK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MEK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MEK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MEK on scaffold (1)
 
   kon
Value: 10.0
Constant
 
dissociation of MEK from scaffold (1)
 
   koff
Value: 0.5
Constant
 
binding of MEK-P on scaffold (1)
 
   kpon