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Cdc13_Cdc2 creation |
→ [Cdc13_Cdc2]; |
Math: |
(Details: ) |
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Cig2_Cdc2 creation |
→ [Cig2_Cdc2]; |
Math: |
(Details: ) |
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Cdc2 phosphorylation |
[Cdc13_Cdc2] ↔ [Cdc13_P-Cdc2];
{Wee1} , {Cdc25}
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Math: |
(Details: ) |
Annotations: |
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binding of Rum1 with Cdc13_Cdc2 |
[Cdc13_Cdc2] + [FreeRum1] ↔ [Cdc13_Cdc2_Rum1]; |
Math: |
(Details: ) |
Annotations: |
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binding of Rum1 with Cdc13_P-Cdc2 |
[Cdc13_P-Cdc2] + [FreeRum1] ↔ [Cdc13_P-Cdc2_Rum1]; |
Math: |
(Details: ) |
Annotations: |
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Rum1 degradation in Rum1_Cdc13_Cdc2 |
[Cdc13_Cdc2_Rum1] → [Cdc13_Cdc2]; |
Math: |
(Details: ) |
Annotations: |
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Rum1 degradation in solution |
[FreeRum1] → ; |
Math: |
(Details: ) |
Annotations: |
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Rum1 degradation in Rum1_Cdc13_P-Cdc2 |
[Cdc13_P-Cdc2_Rum1] → [Cdc13_P-Cdc2]; |
Math: |
(Details: ) |
Annotations: |
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Rum1 degradation in Rum1_Cig2_Cdc2 |
[Cig2_Cdc2_Rum1] → [Cig2_Cdc2]; |
Math: |
(Details: ) |
Annotations: |
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Cdc13 degradation in Cdc13_Cdc2 |
[Cdc13_Cdc2] → ;
{ubiquitinProtease1}
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Math: |
(Details: ) |
Annotations: |
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Cdc13 degradation in Cdc13_P-Cdc2 |
[Cdc13_P-Cdc2] → ;
{ubiquitinProtease1}
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Math: |
(Details: ) |
Annotations: |
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Cig2 degradation in Cig2_Cdc2 |
[Cig2_Cdc2] → ;
{ubiquitinProtease2}
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Math: |
(Details: ) |
Annotations: |
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Cdc13 degradation in Rum1_Cdc13_P-Cdc2 |
[Cdc13_P-Cdc2_Rum1] → [FreeRum1]; |
Math: |
(Details: ) |
Annotations: |
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Cdc13 degradation in Rum1_Cdc13_Cdc2 |
[Cdc13_Cdc2_Rum1] → [FreeRum1]; |
Math: |
(Details: ) |
Annotations: |
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Cig2 degradation in Rum1_Cig2_Cdc2 |
[Cig2_Cdc2_Rum1] → [FreeRum1]; |
Math: |
(Details: ) |
Annotations: |
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Binding of Rum1 to Cig2_Cdc2 |
[Cig2_Cdc2] + [FreeRum1] ↔ [Cig2_Cdc2_Rum1]; |
Math: |
(Details: ) |
Annotations: |
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UbE mediated degradation of Cdc13_Cdc2 in Rum1_Cdc13_Cdc2 |
[Cdc13_Cdc2_Rum1] → [FreeRum1];
{ubiquitinProtease1}
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Math: |
(Details: ) |
Annotations: |
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UbE mediated degradation of Cdc13_Cdc2 in Rum1_Cdc13_P-Cdc2 |
[Cdc13_P-Cdc2_Rum1] → [FreeRum1];
{ubiquitinProtease1}
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Math: |
(Details: ) |
Annotations: |
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Rum1 creation |
→ [FreeRum1]; |
Math: |
(Details: ) |
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Rum1 degradation by SPF |
[FreeRum1] → ;
{S-phasePromotingFactor}
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Math: |
(Details: ) |
Annotations: |
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IE production & degradation |
[BoundIntermediaryEnzyme] ↔ [IntermediaryEnzyme];
{M-phasePromotingFactor}
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Math: |
(Details: ) |
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UbE production & degradation |
[BoundUbiquitinProtease1] ↔ [ubiquitinProtease1];
{IntermediaryEnzyme}
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Math: |
(Details: ) |
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UbE2 production & degradation |
[BoundUbiquitinProtease2] ↔ [ubiquitinProtease2];
{M-phasePromotingFactor}
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Math: |
(Details: ) |
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Wee1 production & degradation |
[BoundWee1] ↔ [Wee1];
{M-phasePromotingFactor}
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Math: |
(Details: ) |
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Cdc25 production & degradation |
[BoundCdc25] ↔ [Cdc25];
{M-phasePromotingFactor}
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Math: |
(Details: ) |
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Rate Rule (name: Mass) |
d [
Mass] / d t= Mass*mu |
Math: |
(Details: ) |
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Assignment Rule (name: IEB) |
BoundIntermediaryEnzyme = 1-IE |
Math: |
(Details: ) |
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Assignment Rule (name: UbEB) |
BoundUbiquitinProtease1 = 1-UbE |
Math: |
(Details: ) |
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Assignment Rule (name: UbE2B) |
BoundUbiquitinProtease2 = 1-UbE2 |
Math: |
(Details: ) |
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Assignment Rule (name: Wee1B) |
BoundWee1 = 1-Wee1 |
Math: |
(Details: ) |
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Assignment Rule (name: Cdc25B) |
BoundCdc25 = 1-Cdc25 |
Math: |
(Details: ) |
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Assignment Rule (name: Rum1Total) |
TotalRum1 = G1R+G2R+PG2R+R |
Math: |
(Details: ) |
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Assignment Rule (name: Cdc13Total) |
TotalCdc13 = G2K+G2R+PG2+PG2R |
Math: |
(Details: ) |
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Assignment Rule (name: Cig2Total) |
TotalCig2 = G1K+G1R |
Math: |
(Details: ) |
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Assignment Rule (name: k2) |
k2 = UbE*V2+(1-UbE)*V2prime |
Math: |
(Details: ) |
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Assignment Rule (name: k6) |
k6 = UbE2*V6+(1-UbE2)*V6prime |
Math: |
(Details: ) |
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Assignment Rule (name: kwee) |
kwee = Vwprime*(1-Wee1)+Vw*Wee1 |
Math: |
(Details: ) |
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Assignment Rule (name: k25) |
k25 = Cdc25*V25+(1-Cdc25)*V25prime |
Math: |
(Details: ) |
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Assignment Rule (name: MPF) |
M-phasePromotingFactor = G2K+beta*PG2 |
Math: |
(Details: ) |
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Assignment Rule (name: SPF) |
S-phasePromotingFactor = Cig1+alpha*G1K+MPF |
Math: |
(Details: ) |
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S-Phase Start |
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Trigger: |
SPF >= 0.1 |
Delay: |
60 |
Annotations: |
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Cell Division |
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Trigger: |
UbE <= 0.1 |
Annotations: |
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