BIOMD0000000002 - Edelstein1996_EPSP_AChSpecies

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Reference Publication

Publication ID: 8983160

Edelstein SJ, Schaad O, Henry E, Bertrand D, Changeux JP.
A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions.
Biol Cybern 1996 Nov;75(5):361-79.
Département de Biochimie, Université de Geneve, Switzerland. Stuart.Edelstein@biochem.unige.ch [more]

Model

Original Model: BIOMD0000000002.xml.origin

Submitter: Nicolas Le Novère

Submission ID: MODEL6614086398

Submission Date: 13 Sep 2005 12:23:07 UTC

Last Modification Date: 21 Oct 2010 14:02:18 UTC

Creation Date: 02 Feb 2005 14:41:42 UTC

Encoders:

Nicolas Le Novère

set #1

bqbiol:is

Taxonomy Torpedo californica

set #2

bqbiol:isVersionOf

Gene Ontology cell surface receptor signaling pathway
Gene Ontology neuromuscular synaptic transmission

Notes

Model of a nicotinic EPSP in a Torpedo electric organ by Edelstein et al (1996)

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2012 The BioModels.net Team.
For more information see the terms of use.
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

Model

Publication ID: 8983160

Submission Date: 13 Sep 2005 12:23:07 UTC

Last Modification Date: 21 Oct 2010 14:02:18 UTC

Creation Date: 02 Feb 2005 14:41:42 UTC

Mathematical expressions

Reactions
React0	React1	React2	React3
React4	React5	React6	React7
React8	React9	React10	React11
React12	React13	React14	React15
React16

Physical entities

Compartments	Species
compartment1	BasalACh2	IntermediateACh	ActiveACh
	Active	BasalACh	Basal
	DesensitisedACh2	Desensitised	IntermediateACh2
	DesensitisedACh	Intermediate	ActiveACh2
	ACh

Global parameters

kf_0	kr_0	kf_1	kr_1
kf_2	kr_2	kf_3	kr_3
kf_4	kr_4	kf_5	kr_5
kf_6	kr_6	kf_7	kr_7
kf_8	kr_8	kf_9	kr_9
kf_10	kr_10	kf_11	kr_11
kf_12	kr_12	kf_13	kr_13
kf_14	kr_14	kf_15	kr_15
kf_16	kr_16

Reactions (17)

React0

[Basal] + [ACh] ↔ [BasalACh];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine binding

Notes:

first ligand on basal

React1

[BasalACh] + [ACh] ↔ [BasalACh2];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine binding

Notes:

second ligand on basal

React2

[BasalACh2] ↔ [ActiveACh2];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine-activated cation-selective channel activity

Notes:

opening of biliganded

React3

[Active] + [ACh] ↔ [ActiveACh];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine binding

Notes:

first ligand on active

React4

[ActiveACh] + [ACh] ↔ [ActiveACh2];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine binding

Notes:

second ligand on active

React5

[Basal] ↔ [Active];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine-activated cation-selective channel activity

Notes:

opening of unliganded

React6

[BasalACh] ↔ [ActiveACh];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine-activated cation-selective channel activity

Notes:

opening of monoliganded

React7

[Intermediate] + [ACh] ↔ [IntermediateACh];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine binding

Notes:

first ligand on intermediate

React8

[IntermediateACh] + [ACh] ↔ [IntermediateACh2];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine binding

Notes:

second ligand on intermediate

React9

[Active] ↔ [Intermediate];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine-activated cation-selective channel activity

Notes:

unlig act <=> unlig interm

React10

[ActiveACh] ↔ [IntermediateACh];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine-activated cation-selective channel activity

Notes:

monolig act <=> monolig interm

React11

[ActiveACh2] ↔ [IntermediateACh2];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine-activated cation-selective channel activity

Notes:

bilig act <=> bilig interm

React12

[Desensitised] + [ACh] ↔ [DesensitisedACh];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine binding

Notes:

first ligand on desensitised

React13

[DesensitisedACh] + [ACh] ↔ [DesensitisedACh2];

Math:

(Details: $View Math$ )

Annotations:

set #1

bqbiol:is

Gene Ontology acetylcholine binding

Notes:

second ligand on desensitised

React14

[Intermediate] ↔ [Desensitised];

Math:

(Details: $View Math$ )

Notes:

unlig interm <=> unlig desen

React15

[IntermediateACh] ↔ [DesensitisedACh];

Math:

(Details: $View Math$ )

Notes:

monolig interm <=> monolig desen

React16

[IntermediateACh2] ↔ [DesensitisedACh2];

Math:

(Details: $View Math$ )

Notes:

bilig interm <=> bilig desen

compartment1

Spatial dimensions: 3 Compartment size: 1.0E-16

BasalACh2

Compartment: compartment1

Initial amount: 0.0

IntermediateACh

Compartment: compartment1

Initial amount: 0.0

ActiveACh

Compartment: compartment1

Initial amount: 0.0

Active

Compartment: compartment1

Initial amount: 0.0

BasalACh

Compartment: compartment1

Initial amount: 0.0

Basal

Compartment: compartment1

Initial amount: 1.0E-22

DesensitisedACh2

Compartment: compartment1

Initial amount: 0.0

Desensitised

Compartment: compartment1

Initial amount: 0.0

IntermediateACh2

Compartment: compartment1

Initial amount: 0.0

DesensitisedACh

Compartment: compartment1

Initial amount: 0.0

Intermediate

Compartment: compartment1

Initial amount: 0.0

ActiveACh2

Compartment: compartment1

Initial amount: 0.0

ACh

Compartment: compartment1

Initial amount: 1.0E-21

Global Parameters (34)

kf_0

Value: 3.0E8

Constant

kr_0

Value: 8000.0

Constant

kf_1

Value: 1.5E8

Constant

kr_1

Value: 16000.0

Constant

kf_2

Value: 30000.0

Constant

kr_2

Value: 700.0

Constant

kf_3

Value: 3.0E8

Constant

kr_3

Value: 8.64

Constant

kf_4

Value: 1.5E8

Constant

kr_4

Value: 17.28

Constant

kf_5

Value: 0.54

Constant

kr_5

Value: 10800.0

Constant

kf_6

Value: 130.0

Constant

kr_6

Value: 2740.0

Constant

kf_7

Value: 3.0E8

Constant

kr_7

Value: 4.0

Constant

kf_8

Value: 1.5E8

Constant

kr_8

Value: 8.0

Constant

kf_9

Value: 19.7

Constant

kr_9

Value: 3.74

Constant

kf_10

Value: 19.85

Constant

kr_10

Value: 1.74

Constant

kf_11

Value: 20.0

Constant

kr_11

Value: 0.81

Constant

kf_12

Value: 3.0E8

Constant

kr_12

Value: 4.0

Constant

kf_13

Value: 1.5E8

Constant

kr_13

Value: 8.0

Constant

kf_14

Value: 0.05

Constant

kr_14

Value: 0.0012

Constant

kf_15

Value: 0.05

Constant

kr_15

Value: 0.0012

Constant

kf_16

Value: 0.05

Constant

kr_16

Value: 0.0012

Constant

Representative curation result(s)

Representative curation result(s) of BIOMD0000000002

Curator's comment: (updated: 21 Oct 2010 15:01:54 BST)

Recalculations of the time courses shown in figures 4b of the original publication. The simulation was performed with Copasi 4.6.32.

Computational Systems Neurobiology Group, European Bioinformatics Institute.

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