Bertone Group

The Bertone Group analyses genetic and biochemical mechanisms underlying cellular differentiation events, particularly in human and mouse embryonic stem (ES) cell lines.

A primary focus is to map the global transcriptomic and proteomic activity of ES cells during various stages of differentiation and lineage commitment in tissue culture. This work involves the development and application of advanced genomic, proteomic and computational methods, realised in part through several collaborative research projects established with experimental laboratories. A second interest is the integration and analysis of data from related work on epigenetic imprinting and gene suppression studies, providing key insights into the effects of chromatin modification on the determination of cell fate.

The generation of large-scale data from microarray and functional genomic experiments will help to identify and characterise the regulatory influence of key transcription factors, signaling genes and non-coding RNAs involved in early developmental pathways, leading to a more detailed understanding of the molecular mechanisms of vertebrate embryogenesis.

The Bertone group is headed by Paul Bertone.