A sequence search can be performed on the ASD database (genes, splice patterns, exons, and peptides) via WU-BLAST2 or FASTA

The ASD workbench has various tools to analyse properties of alternative splicing sites.

Download

Human AltSplice

Mouse AltSplice

AEdb

EBI Databases Nucleotide Databases ASD

Alternative Splicing Database Project

Please Note:

The ASD and ATD databases are now combined into one.

The new database is named ASTD - Alternative Splicing and Transcript Diversity database, and exhibits no loss of functionality or data.

Database release is accompanied with greatly improved web interfaces that can be viewed at http://www.ebi.ac.uk/astd

The current structure of the database is now in:

ftp.ebi.ac.uk/pub/databases/astd.

You may find the previous releases of ASD and ATD at this new location.

The Alternate Transcript Diversity Project (ATD) Project aims to understand the mechanisms that are responsible for the formation of transcript isoforms on a genome-wide scale by creating a value-added database of full-length alternate transcripts from human and mouse.

The AltTrans pipeline extends upon the AltSplice pipeline to derive Transcript Patterns from AltSplice Splice Patterns - a Transcript Pattern is one which is annotated for transcription start site, splicing and the terminating polyA site.

The Alternative Splicing Database (ASD) Project aims to understand the mechanism of alternative splicing on a genome-wide scale by creating a database of alternative splice events and the resultant isoform splice patterns of genes from human, and other model species.

Publications

When citing ASD, or AltSplice, please use:

Stamm S, Riethoven J-JM, Le Texier V, Gopalakrishnan C, Kumanduri V, Tang Y, Barbosa-Morais NL, Thanaraj TA. ASD: a bioinformatics resource on alternative splicing.. Nucleic Acids Res 2006 34: D46-D55.
Thanaraj T.A., Stamm S., Clark F., Riethoven J.J.M, Le Texier V., and Muilu J. ASD: the Alternative Splicing Database. Nucl. Acids. Res. 2004 32: D64-D69.
Clark F. and Thanaraj T.A. Categorization and characterization of transcript-confirmed constitutively and alternatively spliced introns and exons from human. Human Molecular Genetics 2002 11: 451-464 .

News

We are pleased to announce that new interfaces will be available in 2007. ASD and ATD websites will be merged into one website called ASTD. You can see some screenshots by clicking here.

Tools

We have developed a workbench with tools relating to alternative splicing. The ASD Workbench can be accessed at http://www.ebi.ac.uk/asd-srv/wb.cgi. As part of the consortium effort the Bork group at EMBL-Heidelberg have developed a text minig tool that collects PubMed entries pertaining alternative splicing. It can be accessed at http://www.bork.embl.de/LSAT/

The ASD project at EBI is headed by Eleanor Whitfield and Gautier Koscielny and was initiated and headed (until 31 August 2005) by Alphonse Thanaraj Thangavel. The ASD-EBI team is supported by grants from the EC: ATD consortium (LSHG-CT-2003-503329) and the Eurasnet consortium (LSHG-CT-2005-518238). It was supported by the ASD grant from the EC (QLRT-CT-2001-02062) until November 2005.

Other related project by AltSplice team : ATD-AltTrans