Investigation Title	Transcription profiling of human cutaneous B-cell lymphoma skin punch biopsies, mycosis fungoides (MF) and 3 normal skin biopsies 	
Comment[Submitted Name]	Gene Expression Profiles of cutaneous B-cell lymphoma	
Experimental Design	unknown_experiment_design_type	transcription profiling by array	
Experimental Design Term Source REF		EFO	
Comment[ArrayExpressReleaseDate]	2005-10-07	
Comment[AEMIAMESCORE]	3	
Comment[ArrayExpressAccession]	E-SMDB-1798	
Comment[MAGETAB TimeStamp_Version]	2011-01-23 13:31:55 Last Changed Rev: 14857	
Experimental Factor Name	
Experimental Factor Type	
Experimental Factor Term Source REF	
Person Last Name	Demeter	Vanoli-Storz	
Person First Name	Janos	Monique	
Person Mid Initials	
Person Email	jdemeter@genome.stanford.edu	monique.storz@usz.ch	
Person Phone	726-0075	01141 44 255 11 11	
Person Fax	723-7016	01141 44 255 41 65	
Person Address	Dept. Genetics, CCSR 2255, Stanford, CA, USA, 94305	Department of Dermatology, Gloriastrasse 31, Zurich, ZH, Switzerland	
Person Affiliation	Stanford University	University of Zurich	
Person Roles	submitter	submitter	
Person Roles Term Source REF	mo		
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Date of Experiment	
Public Release Date	2005-10-07	
PubMed ID	
Publication DOI	
Publication Author List	Storz MN, Van De Rijn M, Kim YH, Mraz-Gernhard S, Hoppe RT, Kohler S	
Publication Title	Gene expression profiles of cutaneous B cell lymphoma	
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Publication Status Term Source REF	
Experiment Description	We studied gene expression profiles of 17 cutaneous B-cell lymphomas that were collected with 4-6 millimeter skin punch biopsies. We also included tissue from 2 cases of mycosis fungoides (MF), 3 normal skin biopsies and 3 tonsils to create a framework for further interpretation. A hierarchical cluster algorithm was applied for data analysis. Our results indicate that small amounts of skin tissue can be used successfully to perform microarray analysis and result in distinct gene expression patterns. Duplicate specimens clustered together demonstrating a reproducible technique. Within the cutaneous B-cell lymphoma specimens two specific B-cell differentiation stage signatures of germinal center B-cells and plasma cells could be identified. Primary cutaneous follicular and primary cutaneous diffuse large B-cell lymphomas had a germinal center B-cell signature while a subset of marginal zone lymphomas demonstrated a plasma cell signature. Primary and secondary follicular B-cell lymphoma of the skin were closely related, despite previously reported genetic and phenotypic differences. In contrast primary and secondary cutaneous diffuse large B-cell lymphoma were less related to each other. This pilot study allows a first glance into the complex and unique microenvironment of B-cell lymphomas of the skin and provides a basis for future studies, that may lead to the identification of potential histologic and prognostic markers as well as therapeutic targets.	
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SDRF File	E-SMDB-1798.sdrf.txt	
Term Source Name	ncbitax	mo	ArrayExpress	EFO	mo	
Term Source File	http://www.ncbi.nlm.nih.gov/Taxonomy/taxonomyhome.html	http://mged.sourceforge.net/ontologies/MGEDontology.php	http://www.ebi.ac.uk/arrayexpress	http://www.ebi.ac.uk/efo/	http://mged.sourceforge.net/ontologies/MGEDontology.php	
Term Source Version