Comment[ArrayExpressAccession]	E-MTAB-1174
Investigation Title	Transcription profiling by array of human blood from a general population (KORA)																				
Comment[Submitted Name]	Transcription profiling by array of human blood from a general population (KORA)
Experiment Description	The development of whole genome association studies from the general population has lead to the robust identification of several loci involved in different common human diseases. Interestingly, most of the strongest signals of association observed in these studies arise from non-coding regions, raising the possibility that these regions are involved in the etiology of the disease through regulatory mechanisms. These findings highlight the importance of better understanding the inter-individual differences in gene expression in humans. The aim of the study was to search for biomarker, to identify eQTLs and to elucidate whether whole-blood eQTLs allow to identify putative functional variants involved in the etiology of complex traits. Note: Due to ethical issues no phenotypic information is provided.																				
Experimental Design	translational_design	co-expression_design	population based design																		
Comment[AEExperimentType]	transcription profiling by array																				
Comment[Submitted Name] 	Whole blood expression profiling from a general population (KORA)																				
Experimental Factor Name	INDIVIDUAL																				
Experimental Factor Type	individual																				
Quality Control Type																					
Public Release Date	2013-02-01																				
Person Last Name	Prokisch																				
Person First Name	Holger																				
Person Mid Initials																					
Person Email	prokisch@helmholtz-muenchen.de																				
Person Phone	#49 8931872890																				
Person Address	Ingolstaedter Landstr. 1, D-85764 Neuherberg																				
Person Affiliation	Institute of Human Genetics, Helmholtz Zentrum München, Munich, Germany																				
Person Roles	submitter																				
PubMed ID																					
Publication Author List	Christian Herder, Maren Carstensen, Sandra Landwehr, Katharina Heim, Wolfgang Rathmann, Barbara Thorand, Christa Meisinger, Gertrud Eckstein, Thomas Meitinger, H.-Erich Wichmann, Stephan Martin, Klaus Strassburger, Wolfgang Koenig, Rui Wang-Sattler, Guido Giani, Helmut Finner, Michael Roden, Thomas Illig, Holger Prokisch																				
Publication Title	Gene Expression Data From a Genomewide Transcriptomics Study Improve the Prediction of Type 2 Diabetes																				
Publication Status	in preparation																				
Protocol Name	P-MTAB-26999	P-MTAB-27000	P-MTAB-27001	P-MTAB-27002	P-MTAB-27003	P-MTAB-27004	P-MTAB-27005
Protocol Type	specified_biomaterial_action	nucleic_acid_extraction	labeling	hybridization	image_acquisition	bioassay_data_transformation	bioassay_data_transformation														
Protocol Description	No treatment carried out just fasting conditions	RNA extraction with PAXgene (BD) Blood miRNA kit (Qiagen)	RNA was reverse transcribed and biotin-UTP-labeled into cRNA using the Illumina TotalPrep-96 RNA Amplification kit	cRNA was hybridized to Illumina HumanHT-12 v3 Expression BeadChip	Scanning was carried out using the BeadArray Reader S376	Quantile normalization using bioconductor package lumi	log2 transformation														
SDRF File	E-MTAB-1174.sdrf.txt