E-TABM-71 - Transcription profiling of humoral resistance to the CTL after phenotypical and functional study of the resistant clone IGR-HeuR8

Status
Submitted on 20 December 2005, released on 23 January 2006, last updated on 2 May 2014
Organism
Homo sapiens
Samples (2)
Array (1)
Protocols (8)
Description
From a tumoral line IGR-Heu; resulting from a biopsy of the primitive tumour of a patient reached of a bronchial cancer not with small cells (NSCLC); we established; by successive co-cultures of this line with the autologous CTL (clone T H161); a resistant line to the cytotoxic lysis induced by H161 (IGR-HeuR8 line). This resistant line was then cloned by limiting dilutions and a resistant clone was obtained (tumoral clone IGR-HeuR8). The goal of this study is to define profiles of genetic expression of the tumoral resistance to the CTL after phenotypical and functional study of the resistant clone IGR-HeuR8.
Experiment types
transcription profiling by array, compound treatment, disease state
Contacts
Audrey Kauffmann <Philippe.DESSEN@gustaveroussy.fr>, Abdelali Jalil, Catherine Gaudin, Catherine Richon, Fathia Mami-Chouaib and Salem Chouaib, Georges Bismuth, Graca Raposo, Isabelle Vergnon, Jean Dausset, Jérôme Galon, Oliver Caroll, Peter Van Endert, Soraya Abouzahr
Citation
Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure. Abouzahr, Soraya; Bismuth, Georges; Gaudin, Catherine; Caroll, Oliver; Van Endert, Peter; Jalil, Abdelali; Dausset, Jean; Vergnon, Isabelle; Richon, Catherine; Kauffmann, Audrey; Galon, Jerome; Raposo, Graca; Mami-Chouaib, Fathia; Chouaib, Salem. Proc Natl Acad Sci U S A 103(5):1428 (2006), Europe PMC 16432193
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-TABM-71.idf.txt
Sample and data relationshipE-TABM-71.sdrf.txt
Raw data (1)E-TABM-71.raw.1.zip
Processed data (1)E-TABM-71.processed.1.zip
Array designA-MEXP-304.adf.txt
R ExpressionSetE-TABM-71.eSet.r
Links