E-SMDB-1399 - Transcription profiling of C. elegans muscle sample
Submitted on 13 July 2005, released on 13 July 2005, last updated on 27 March 2012
We present a global overview of muscle gene expression in C. elegans using a novel technique called mRNA-tagging, and have identified genes involved in contraction, muscle structure, and energy utilization. Furthermore, we found that muscle-expressed genes are clustered in groups of 2-5 along the chromosomes, suggesting that expression from a chromatin domain can extend over several genes. These observations reveal a higher-order organization of the structure of the genome in which the order of genes along the chromosome is correlated with their expression in specific tissues.
transcription profiling by array, unknown experiment type
Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans. Roy PJ, Stuart JM, Lund J, Kim SK. Nature 418:975-9 (2002-09-07), Europe PMC 12214599