E-MTAB-700 - Kras G12D Mutant vs. Wildtype
Released on 3 June 2011, last updated on 25 January 2012
The experiment is a study of the effects of signal strength in the Ras pathway. In particular, we studied a gain-of-function mutant of Kras, KrasG12D. We generated these mutant mice and performed microarray analyses on RNA extracted from whole skin, comparing KrasG12D mice to wild-type mice, with three replicates of each.
transcription profiling by array, co-expression, genetic modification, in vivo
Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development. Mukhopadhyay A, Krishnaswami SR, Cowing-Zitron C, Hung NJ, Reilly-Rhoten H, Burns J, Yu BD. Dev Biol 373(2):373-382 (2013), Europe PMC 23123965