E-MTAB-2508 - Transcriptional profiling of chronic myelogenous leukemia (CML) and normal, quiescent and dividing haematopoietic cells

Status
Submitted on 15 November 2004, released on 25 April 2014, last updated on 3 June 2014
Organism
Homo sapiens
Samples (15)
Array (1)
Protocols (4)
Description
Quiescent and dividing hemopoietic stem cells (HSC) display marked differences in their ability to move between the peripheral circulation and the bone marrow. Specifically, long-term engraftment potential predominantly resides in the quiescent HSC subfraction, and G-CSF mobilization results in the preferential accumulation of quiescent HSC in the periphery. In contrast, stem cells from chronic myeloid leukemia (CML) patients display a constitutive presence in the circulation. To understand the molecular basis for this, we have used microarray technology to analyze the transcriptional differences between dividing and quiescent, normal, and CML-derived CD34+ cells.
Experiment types
transcription profiling by array, case control design, cell type comparison design, disease state design
Contacts
Citation
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-MTAB-2508.idf.txt
Sample and data relationshipE-MTAB-2508.sdrf.txt
Raw data (1)E-MTAB-2508.raw.1.zip
Array designA-AFFY-33.adf.txt
Links