E-MTAB-2334 - Transcription profiling by array of mouse oesophageal epithelium basal cells comparing DNMaml expressing cells versus controls
Released on 8 April 2014, last updated on 3 June 2014
Multiple cancers may arise from within a clonal region of preneoplastic epithelium, a phenomenon termed ‘field change’. However, it is not known how field change develops. We investigate this question and analyse the behavior of scattered single esophageal epithelial progenitor cells expressing a mutation that inhibits the Notch signaling pathway (Dominant negative Maml).
transcription profiling by array, co-expression, development or differentiation design, in vivo
Differentiation imbalance in single esophageal progenitor cells causes clonal immortalization and field change. Maria P. Alcolea, Philip Greulich, Agnieszka Wabik, Benjamin D. Simons,Philip H. Jones.