E-MTAB-2234 - RNA-seq of coding RNA from whole blood samples of pigs before and after Salmonella enterica serovar Typhimurium challenge and with different levels of faecal Salmonella shedding

Status
Last updated on 11 June 2014, released on 11 June 2014
Organism
Sus scrofa
Samples (32)
Protocols (7)
Description
Salmonella enterica serovar Typhimurium is a gram-negative bacterium that can colonize the gut of humans and several species of food producing farm animals to cause enteric or septicaemic salmonellosis. Besides compromising public health and food safety, sub-clinical salmonellosis is also believed to be a major problem affecting the profitability of the pig industry. Distinct responses to Salmonella infection have been observed in pigs, some recovering faster and shedding lower levels of Salmonella in faeces than others (low shedders, LS versus persistent shedders, PS). This trait variation could indicate the existence of a genetic component to Salmonella shedding and resistance that may be exploited in animal breeding and disease diagnostics. The study aimed to identify porcine genes and gene co-expression networks that differentiate distinct responses to Salmonella challenge with respect to faecal Salmonella shedding.
Experiment types
RNA-seq of coding RNA, co-expression, disease state design, in vivo
Contacts
Citation
Gene co-expression network analysis identifies porcine genes associated with variation in Salmonella shedding. Kommadath A, Bao H, Arantes AS, Plastow GS, Tuggle CK, Bearson SM, Guan LL, Stothard P. BMC Genomics 15:452 (2014), Europe PMC 24912583
MINSEQE
Exp. designProtocolsFactorsProcessedSeq. reads
Files
Investigation descriptionE-MTAB-2234.idf.txt
Sample and data relationshipE-MTAB-2234.sdrf.txt
Processed data (1)E-MTAB-2234.processed.1.zip
Links