E-MTAB-2234 - RNA-seq of coding RNA from whole blood samples of pigs before and after Salmonella enterica serovar Typhimurium challenge and with different levels of faecal Salmonella shedding
Released on 11 June 2014, last updated on 26 October 2015
Salmonella enterica serovar Typhimurium is a gram-negative bacterium that can colonize the gut of humans and several species of food producing farm animals to cause enteric or septicaemic salmonellosis. Besides compromising public health and food safety, sub-clinical salmonellosis is also believed to be a major problem affecting the profitability of the pig industry. Distinct responses to Salmonella infection have been observed in pigs, some recovering faster and shedding lower levels of Salmonella in faeces than others (low shedders, LS versus persistent shedders, PS). This trait variation could indicate the existence of a genetic component to Salmonella shedding and resistance that may be exploited in animal breeding and disease diagnostics. The study aimed to identify porcine genes and gene co-expression networks that differentiate distinct responses to Salmonella challenge with respect to faecal Salmonella shedding.
RNA-seq of coding RNA, co-expression, disease state design, in vivo
Gene co-expression network analysis identifies porcine genes associated with variation in Salmonella shedding. Kommadath A, Bao H, Arantes AS, Plastow GS, Tuggle CK, Bearson SM, Guan LL, Stothard P. BMC Genomics 15:452 (2014), Europe PMC 24912583
Genome-wide whole blood microRNAome and transcriptome analyses reveal miRNA-mRNA regulated host response to foodborne pathogen Salmonella infection in swine. Hua Bao, Arun Kommadath, Guanxiang Liang, Xu Sun, Adriano S. Arantes, Christopher K. Tuggle, Shawn M.D. Bearson, Graham S. Plastow, Paul Stothard & Le Luo Guan. 5:12620 (2015), Europe PMC 26227241