E-MTAB-2068 - Transcription profiling by array of human CD8-positive T cells from patients with LGL leukemia

Status
Released on 14 November 2013, last updated on 3 June 2014
Organism
Homo sapiens
Samples (8)
Array (1)
Protocols (6)
Description
LGL leukemia is chronic clonal lymphoproliferative disorder, characterized by expansion of cytotoxic CD8+ T-cells or NK-cells. We compared gene expression of 2 LGL leukemia patients with STAT3 mutation (Patients 11 and 12) and 2 LGL leukemia patients without STAT3/STAT5b mutation (Patients 9 and 10) with CD8 and CD4 samples from healthy controls to assess different gene expression patterns between samples.
Experiment types
transcription profiling by array, co-expression, disease state, in vitro
Contacts
Citation
Novel Somatic Mutations in Large Granular Lymphocytic Leukemia affecting the STAT-pathway and T-cell activation. Emma I Andersson, Hanna L M Rajala, Samuli Eldfors, Pekka Ellonen, Thomas Olson, Andres Jerez, Michael J. Clemente, Olli Kallioniemi, Kimmo Porkka, Caroline Heckman, Thomas P. Loughran Jr., Jaroslaw P. Maciejewski and Satu Mustjoki.
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-2068.idf.txt
Sample and data relationshipE-MTAB-2068.sdrf.txt
Raw data (1)E-MTAB-2068.raw.1.zip
Processed data (1)E-MTAB-2068.processed.1.zip
Array designA-MEXP-2072.adf.txt
Links