E-MTAB-2054 - Transcription profiling by array of maternal whole blood samples comparing gene expression in pregnancies where the fetus was hypoxic at birth compared to those where the fetus was normoxic at birth

Status
Released on 8 May 2014, last updated on 3 June 2014
Organism
Homo sapiens
Samples (8)
Array (1)
Protocols (6)
Description
Microarray of whole blood maternal samples comparing the expression of genes in the maternal blood in pregnancies where the fetus was hypoxic at birth compared to those where the fetus was normoxic at birth. Intrapartum hypoxia is associated with severe neonatal morbidity and mortality. Current techniques to assess fetal hypoxic status during labour have a poor sensitivity. At birth, the lactate level in umbilical cord blood is used to assess the degree of fetal hypoxia during birth, such that a high lactate reflects a hypoxic fetus and a low lactate a normoxic fetus. We collected maternal blood prior to delivery and compared the expression of genes in the maternal blood in women delivering a normoxic or hypoxic fetus as evidenced by umbilcal cord blood levels.
Experiment types
transcription profiling by array, co-expression, in vivo, stimulus or stress
Contact
Citation
Quantifying circulating hypoxia-induced RNA transcripts in maternal blood to determine in utero fetal hypoxic status. Clare Whitehead, Wan T Teh, Susan P Walker, Cheryl Leung, Sonali Mendis, Luke Lamour and Stephen Tong.
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-2054.idf.txt
Sample and data relationshipE-MTAB-2054.sdrf.txt
Raw data (1)E-MTAB-2054.raw.1.zip
Processed data (1)E-MTAB-2054.processed.1.zip
Array designA-MEXP-1172.adf.txt
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