E-MTAB-2053 - Transcription profiling by array of human lineage-negative, CD34+, CD133+ cells and unseparated nucleated cells to better characterise the human umbilical cord blood-derived stem/progenitor cells
Released on 20 November 2013, last updated on 3 February 2014
Stem/progenitor cells demonstrate neuro-regenerative potential that is dependent upon their humoral activity by producing various trophic factors that regulate cell migration, growth, and differentiation. To better characterise the human umbilical cord blood-derived stem/progenitor cells, we analyzed the global gene expression pattern in the lineage-negative, CD34+, CD133+ cells and unseparated nucleated cells. We were interested in biological processes concerning biosynthetic processes, cytokine production, secretion by cells, chemotaxis, migration, and proliferative capacities.
transcription profiling by array, cell type comparison design, co-expression, ex vivo
Humoral activity of cord blood-derived stem/progenitor cells: implications for stem cell-based adjuvant therapy of neurodegenerative disorders. Paczkowska E, Kaczynska K, Pius-Sadowska E, Roginska D, Kawa M, Ustianowski P, Safranow K, Celewicz Z, Machalinski B. PLoS One 8(12):e83833 (2013), Europe PMC 24391835