E-MTAB-2026 - Transcriptional profiling of miRNA in CD4+ T-cells from brain of EAE+Vehicle and EAE+DIM mice
Last updated on 27 October 2013, released on 1 November 2013
C57BL/6 mice were immunized by subcutaneous injection of MOG35-55 peptide.DIM post-treatment was given at DAY 10 of the disease progression. CD4 T cells were isolated from the brain of the mice on day 15 of the MOG35-55 peptide immunization. Total RNA was extracted and subjected to microRNA high-throughput array with Affymetrix platform.
microRNA profiling by array, compound treatment, ex vivo, translational bias
Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells. Rouse M, Singh NP, Nagarkatti PS, Nagarkatti M.