E-MTAB-1990 - ChIP-seq of pancreatic progenitor cells derived in vitro from human embryonic stem cells in order to study the epigenomic mechanisms involved in pancreas development
Released on 15 November 2013, last updated on 2 May 2014
Active regulatory regions in the human embryonic pancreatic progenitors were profiled by integration of transcription factor and histone modification ChIP-seq datasets. These were obtained from pancreatic progenitor cells derived in vitro from human embryonic stem cells. The purpose of this work was to study the epigenomic mechanisms involved in pancreas development.
ChIP-seq, development or differentiation design, in vitro
Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis. Weedon MN, Cebola I, Patch AM, Flanagan SE, De Franco E, Caswell R, Rodr’guez-Segu’ SA, Shaw-Smith C, Cho CH, Allen HL, Houghton JA, Roth CL, Chen R, Hussain K, Marsh P, Vallier L, Murray A, International Pancreatic Agenesis Consortium, Ellard S, Ferrer J, Hattersley AT. , Europe PMC 24212882