E-MTAB-1970 - Transcription profiling by array of mouse placentas from two transgenic STOX1-overexpressing strains (which show preeclampsia-like symptoms) and non-transgnic controls with and without aspirin, a drug which can revert such symptoms

Status
Released on 11 October 2013, last updated on 3 June 2014
Organism
Mus musculus
Samples (12)
Array (1)
Protocols (6)
Description
STOX1 overexpressing placentas generate preeclampsia-like symptoms in pregnant mice. These symptoms are reverted by aspirin. The experiment aims at analyzing placental expression in Transgenic/non transgenic with and withou aspirin, in the placentas at 16,5 days post-coïtum. There are two strains of transgenic mice that express the transgene at different levels: STOX42 about 15 fold that of STOX13. STOX13 expressed the human STOX1 roughly at the level of the mouse endogeneous Stox1 in the placenta.
Experiment types
transcription profiling by array, co-expression, genetic modification
Contact
Citation
Nitroso-Redox Balance and Mitochondrial Homeostasis Are Regulated by STOX1, a Pre-Eclampsia-Associated Gene. Doridot L, Châtre L, Ducat A, Vilotte JL, Lombes A, Mehats C, Barbaux S, Calicchio R, Ricchetti M, Vaiman D. Antioxid Redox Signal 21(6):819-834 (2014), Europe PMC 24738702
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-1970.idf.txt
Sample and data relationshipE-MTAB-1970.sdrf.txt
Raw data (1)E-MTAB-1970.raw.1.zip
Array designA-MEXP-1707.adf.txt
Links