E-MTAB-1970 - Transcription profiling by array of mouse placentas from two transgenic STOX1-overexpressing strains (which show preeclampsia-like symptoms) and non-transgnic controls with and without aspirin, a drug which can revert such symptoms
Released on 11 October 2013, last updated on 3 June 2014
STOX1 overexpressing placentas generate preeclampsia-like symptoms in pregnant mice. These symptoms are reverted by aspirin. The experiment aims at analyzing placental expression in Transgenic/non transgenic with and withou aspirin, in the placentas at 16,5 days post-coïtum. There are two strains of transgenic mice that express the transgene at different levels: STOX42 about 15 fold that of STOX13. STOX13 expressed the human STOX1 roughly at the level of the mouse endogeneous Stox1 in the placenta.
transcription profiling by array, co-expression, genetic modification
Nitroso-Redox Balance and Mitochondrial Homeostasis Are Regulated by STOX1, a Pre-Eclampsia-Associated Gene. Doridot L, Châtre L, Ducat A, Vilotte JL, Lombes A, Mehats C, Barbaux S, Calicchio R, Ricchetti M, Vaiman D. Antioxid Redox Signal 21(6):819-834 (2014), Europe PMC 24738702