E-MTAB-1937 - Comparative genomic hybridization by array of mouse hippocampus and cortex samples from 5xFAD transgenic mutants (a model for early-onset Alzheimer's diease) against samplse from wild-type littermates
Released on 30 April 2014, last updated on 3 June 2014
Little is known about the global molecular changes leading to neurodegeneration and brain dysfunction in Alzheimer's disease (AD). To study the molecular cascades involved, we chose to study the transcriptomic profile of an early-onset AD model, the 5xFAD mice, at different time points (1 month, 4 months, 6 months and 9 months) of the disease. We are also interested in the effects of vitamin D supplementation in AD. Vitamin D receptor belongs to the family of nuclear receptors and vitamin D can act as a neurosteroid by regulating the expression of over a 1000 genes. We therefore decided to evaluate the effect of vitamin D supplementation in this AD mouse model at the transcriptomic level, after 5 months of supplementation (i.e. from 1 month to 6 months and from 4 months to 9 months).
comparative genomic hybridization by array, comparative genome hybridization, disease state, in vivo
Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimers disease. Landel V, Baranger K, Virard I, Loriod B, Khrestchatisky M, Rivera S, Benech P, Féron F. Mol Neurodegener 9:33 (2014), Europe PMC 25213090