E-MTAB-1931 - Transcription profiling by array of mouse spleen tissues from wild-type, Ity14 homozygous mutant and Ity14/wild-type heterozygous mice with or without Salmonella typhimurium infection to study the effect of Ity14 mutant on immunity to the infection
Released on 6 May 2014, last updated on 3 June 2014
Salmonella-related infections outcome are dependent on the complex interaction between environmental factors, bacterial serotype and host genetic factors. Using ENU chemical mutagenesis, we identified a pedigree named Immunity to Typhimurium 14 (Ity14) carrying a mutation in Stat4 (c.1335+5G>A). Here we used a recognized experimental model of systemic Salmonella Typhimurium infection in mice to study the impact of Stat4 mutation on typhoid-like disease. We compare whole-genome transcriptional profiles between wild-type and Ity14 mutant mice to identify common or unique gene expression profiles between these groups.
transcription profiling by array, co-expression, ex vivo, strain or line
Altered IFN-gamma-mediated immunity and transcriptional expression patterns in N-Ethyl-N-nitrosourea-induced STAT4 mutants confer susceptibility to acute typhoid-like disease. Eva M.M., Yuki K.E., Dauphinee S.M., Schwartzentruber J.A., Pyzik M., Paquet M., Lathrop M., Majewski J., Vidal S.M., Malo D. J Immunol (2014)