E-MTAB-1927 - Transcription profiling by array of neurons differentiated from induced pluripotent stem cells carrying a mutation in the SOD1 gene, an expanded GGGGCC repeat mutation in the chromosome 9 open reading frame 72 gene and those without any (control)
Released on 29 October 2013, last updated on 2 May 2014
The purpose of this experiment was to compare differences in the transcript levels between RNA samples from induced pluripotent stem cells differentiated into neurons carrying a mutation in the SOD1 gene, an expanded GGGGCC repeat mutation in the chromosome 9 open reading frame 72 gene and those without any (control).
transcription profiling by array, co-expression, disease state, in vitro
RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention. Donnelly CJ, Zhang PW, Pham JT, Heusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, Rigo F, Bennett CF, Blackshaw S, Sattler R, Rothstein JD. Neuron 80(2):415-428 (2013), Europe PMC 24139042