E-MTAB-1925 - Transcription profiling by array of post-mortem brain cortex from healthy control patients and amyotrophic lateral sclerosis patients that carry an expanded GGGGCC repeat mutation in the chromosome 9 open reading frame 72 (C9ORF72) gene

Status
Released on 29 October 2013, last updated on 2 May 2014
Organism
Homo sapiens
Samples (6)
Array (1)
Protocols (6)
Description
The purpose of this experiment was to compare differences in the transcript level between RNA samples collected from post mortem motor cortex from healthy control patients and amyotrophic lateral sclerosis patients that carry an expanded GGGGCC repeat mutation in the chromosome 9 open reading frame 72 gene.
Experiment types
transcription profiling by array, co-expression, disease state, in vitro
Contacts
Citations
RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention. Donnelly CJ, Zhang PW, Pham JT, Heusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, Rigo F, Bennett CF, Blackshaw S, Sattler R, Rothstein JD. Neuron 80(2):415-428 (2013), Europe PMC 24139042
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Donnelly CJ, Zhang PW, Pham JT, Haeusler AR, Heusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, Rigo F, Bennett CF, Blackshaw S, Sattler R, Rothstein JD. :415-428 (2013), Europe PMC 24139042
RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention. Donnelly CJ, Zhang PW, Pham JT, Heusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, Rigo F, Bennett CF, Blackshaw S, Sattler R, Rothstein JD. Neuron 80(2):415-428 (2013), Europe PMC 24139042
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-1925.idf.txt
Sample and data relationshipE-MTAB-1925.sdrf.txt
Raw data (1)E-MTAB-1925.raw.1.zip
Processed data (1)E-MTAB-1925.processed.1.zip
Array designA-MEXP-2246.adf.txt
Links