E-MTAB-1919 - Pancreatic islet epigenomics reveals enhancer clusters that are enriched in Type 2 diabetes risk variants

Status
Released on 1 January 2014, last updated on 2 May 2014
Organism
Homo sapiens
Samples (12)
Protocols (7)
Description
We combined ChIP-seq of chromatin marks and key islet transcription factor with RNA-seq in human islets to map cis-regulatory networks in this primary tissue. The output of this project provides a reference map to dissect genetic variants that alter the susceptibility for Type 2 diabetes, and assist efforts to generate new beta-cells by transcriptional programming strategies
Experiment types
ChIP-seq, binding site identification design
Contacts
Citation
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk–associated variants. Lorenzo Pasquali, Kyle J. Gaulton, Santiago A. Rodríguez-Seguí, Loris Mularoni, Irene Miguel-Escalada, Ildem Akerman, Juan J. Tena, Ignasi Morán, Carlos Gómez-Marín, Martijn van de Bunt, Joan Ponsa-Cobas, Natalia Castro, Takao Nammo, Inês Cebola, Javier García-Hurtado, Miguel Angel Maestro, François Pattou, Lorenzo Piemonti, Thierry Berney, Anna L. Gloyn, Philippe Ravassard, José Luis Gómez Skarmeta, Ferenc Müller, Mark I. McCarthy, Jorge Ferrer. Nature Genetics  (2014)
MINSEQE
Exp. designProtocolsVariablesProcessedSeq. reads
Files
Investigation descriptionE-MTAB-1919.idf.txt
Sample and data relationshipE-MTAB-1919.sdrf.txt
Processed data (22)Click to browse processed data
Links