E-MTAB-1895 - Transcription profiling by array of adipose tissues from monozygotic twin pairs who have metabolically healthy obesity (MHO) or non-MHO and are weight-discordant
Released on 16 October 2013, last updated on 3 June 2014
Not all obese individuals develop the usual comorbidities (i.e. hypertension, dyslipidemia, diabetes) despite the excess weight. We set out to investigate this metabolically healthy obesity (MHO) phenomenon utilizing a collection of monozygotic twins discordant for obesity. Adipose tissue samples were analyzed for diffences in their transcipt profile between groups of MHO and non-MHO twin pairs.
transcription profiling by array, co-expression, disease state, in vivo
Characterising metabolically healthy obesity in weight-discordant monozygotic twins. Naukkarinen J, Heinonen S, Hakkarainen A, Lundbom J, Vuolteenaho K, Saarinen L, Hautaniemi S, Rodriguez A, Frühbeck G, Pajunen P, Hyötyläinen T, Orešič M, Moilanen E, Suomalainen A, Lundbom N, Kaprio J, Rissanen A, Pietiläinen KH . Diabetologia (2013), Europe PMC 24100782