E-MTAB-1882 - Transcription profiling by array of well-grown compared to not-grown human uterine fibroid xenografts in immunodeficient mice to help understand huamn uterine fibroid disease

Status
Released on 1 May 2014, last updated on 3 June 2014
Organism
Homo sapiens
Samples (94)
Array (1)
Protocols (5)
Description
Human uterine fibroids are benign tumors derived from the smooth muscle layers of the uterus. Fibroid disease impacts up to 50% of premenopausal women in their daily life, and accounts for up to 50% of hysterectomies in the United States. Despite the health burden they impose, the development of these tumors is barely understood. To improve our understanding of this disease, we developed and characterized a patient-derived xenograft models by transplanting small pieces of human uterine fibroid tissue subcutaneously into immunodeficient mice. Growth of the fibroid grafts was dependent on 17beta-estradiol and progesterone supplementation and maintained for up to 60 days. A gene expression profiling study was performed in order to determine molecular characteristis of well-grown compared to not-grown uterine fibroid xenografts.
Experiment types
transcription profiling by array, all pairs, co-expression, growth condition
Contact
Citation
DRAFT: DEVELOPMENT OF A PATIENT DERIVED UTERINE FIBROID XENOGRAFT MODEL IN SCID MICE PREDICTIVE FOR THE IN SITU DISEASE. Martin Fritsch, Nicole Schmidt, Jörg Müller, Ina Gröticke, Anna-Lena Frisk, Anette Sommer, Christopher Keato, Markus Koch, Ov D. Slayden.
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-MTAB-1882.idf.txt
Sample and data relationshipE-MTAB-1882.sdrf.txt
Raw data (1)E-MTAB-1882.raw.1.zip
Array designA-MEXP-1171.adf.txt
Links