E-MTAB-1858 - Transcription profiling by array of xenografted tumors derived from human ovarian cell line model A2780 and its cisplatin resistant variant A2780cis
Released on 1 October 2013, last updated on 3 June 2014
Molecular mechanisms underlying the development of resistance to platinum treatment in patients with ovarian cancer remain poorly understood. This is mainly due to the lack of appropriate in vivo models allowing identification of factors that are regulated during initial treatment and of acquired resistance-related genes. In this study, we used whole genome microarrays and linear model analysis to identify potential resistance-related genes by comparing the expression profiles of the parental human ovarian cancer model A2780 and its cisplatin-resistant variant A2780cis, before and after carboplatin treatment in vivo.
transcription profiling by array, all pairs, co-expression, compound treatment design, in vitro
Knockdown of platinum-induced growth differentiation factor 15 (GDF15) abrogates p27-mediated tumor growth delay in the chemoresistant ovarian cancer model A2780cis in vivo. Julia C. Meier, Bernard Haendler, Henrik Seidel, Philip Groth, Robert Adams, Karl Ziegelbauer, Bertolt Kreft, Georg Beckmann, Anette Sommer and Charlotte Kopitz.