E-MTAB-1816 - Transcription profiling by array of mast cells generated from Mus musculus wild-type (MazrF/F) and MAZR-deficient (MazrF/F x Vav-iCre) bone marrow cells
Released on 18 October 2013, last updated on 3 June 2014
Mast cells are known to be the key players in type I hypersensitivity reactions in humans and mice. They are critically involved in the development of allergic rhinitis, allergic asthma and systemic anaphylaxis. In this study we investigated the role of the transcriptional regulator MAZR in mast cells by comparing the expression profile of mast cells generated from wild-type (MazrF/F) and MAZR-deficient (MazrF/F x Vav-iCre) bone marrow cells. Our results from the array data demonstrate that MAZR acts preferentially as a transcriptional repressor in mast cells.
transcription profiling by array, co-expression, development or differentiation design, genotype design, in vitro
The Transcription Factor MAZR Preferentially Acts as a Transcriptional Repressor in Mast Cells and Plays a Minor Role in the Regulation of Effector Functions in Response to FcεRI Stimulation. Anastasia Abramova, Shinya Sakaguchi, Alexandra Schebesta, Hammad Hassan, Nicole Boucheron, Peter Valent, Axel Roers, Wilfried Ellmeier. PLoS ONE 8(10):e77677 (2013)