E-MTAB-1765 - Transcription profiling by array of muscle and liver tissue from arthritic and non-arthritic mice treated with several doses of prednisolone
Released on 10 November 2013, last updated on 3 June 2014
Prednisolone is a potent anti-inflammatory glucocorticoid (GC) but chronic use is hampered by metabolic side effects. Although GCs are predominantly prescribed for treatment of inflammatory conditions, little is known about their long-term effects on gene-expression in-vivo during inflammation. Here, we aimed to identify genes underlying prednisolone-induced metabolic side effects in a complex in-vivo inflammatory setting after long-term treatment. We performed whole-genome expression profiling in liver and muscle from arthritic and non-arthritic mice treated with several doses of prednisolone for three weeks.
transcription profiling by array, co-expression, compound treatment design, dose response design, in vivo
Identification of gene signatures for prednisolone-induced metabolic dysfunction in collagen-induced arthritis mice. Sandrine Ellero-Simatos, Wilco W. M. Fleuren, Susanne Bauerschmidt, Wim H.A. Dokter and Erik J.M. Toonen.