E-MTAB-1708 - Transcription profiling by array of whole blood samples taken from citizens of the Augsburg region in the KORA F4 study
Released on 13 July 2013, last updated on 3 June 2014
The development of whole genome association studies from the general population has lead to the robust identification of several loci involved in different common human diseases. Interestingly, most of the strongest signals of association observed in these studies arise from non-coding regions, raising the possibility that these regions are involved in the etiology of the disease through regulatory mechanisms. These findings highlight the importance of better understanding the inter-individual differences in gene expression in humans. Aim of the study was to search for biomarker, to identify eQTLs and to elucidate whether whole-blood eQTLs allow to identify putative functional variants involved in the etiology of complex traits. For more information about the KORA F4 study, please see http://www.helmholtz-muenchen.de/en/kora-en/information-for-scientists/current-kora-studies/f4-study/index.html .
transcription profiling by array, co-expression, individual genetic characteristics, replicate
Systematic identification of trans-eQTLs as putative drivers of known disease associations. Harm-Jan Westra, Marjolein J. Peters, Tõnu Esko, Hanieh Yaghootkar, Claudia Schurmann, Johannes Kettunen,Mark W. Christiansen, Benjamin P. Fairfax, Katharina Schramm, Joseph E. Powell, Alexandra Zhernakova, Daria V Zhernakova ,Jan H. Veldink, Leonard H. Van den Berg, Juha Karjalainen, Sebo Withoff, André G. Uitterlinden, Albert Hofman, Fernando Rivadeneira, Peter A C 't Hoen, Eva Reinmaa, Krista Fischer, Mari Nelis, Lili Milani, David Melzer, Luigi Ferrucci, Andrew B. Singleton, Dena G. Hernandez, Michael A. Nalls, Georg Homuth, Matthias Nauck, Dörte Radke, Uwe Völker, Markus Perola, Veikko Salomaa, Jennifer Brody, Astrid Suchy-Dicey, Sina A. Gharib, Daniel A. Enquobahrie, Thomas Lumley, Grant W. Montgomery, Seiko Makino, Holger Prokisch, Christian Herder, Michael Roden, Harald Grallert, Thomas Meitinger, Konstantin Strauch, Yang Li, Ritsert C. Jansen, Peter M. Visscher, Julian C. Knight, Bruce M. Psaty, Samuli Ripatti, Alexander Teumer, Timothy M. Frayling, Andres Metspalu, Joyce B.J. van Meurs, Lude Franke.