E-MTAB-1611 - Transcription profiling by array of samples from patients with large lymphocytic leukemia (LGL) and mutation in STAT3, mutation in STAT5b or no mutations against CD8+ and NK-cell samples from healthy controls
Released on 15 April 2013, last updated on 3 June 2014
Large lymphocytic leukemia (LGL) is a chronic clonal lymphoproliferative disorder, characterized by expansion of cytotoxic CD8+ T-cells or NK-cells. We compared gene expression of 3 LGL leukemia patients with STAT3 mutation (Patients 1, 2, and 3), 3 LGL leukemia patients with STAT5b mutation (Patients 4, 5, and 6), and 2 LGL leukemia patients without STAT3/STAT5b mutation (Patients 7 and 8) with CD8 and NK-cell samples from healthy controls to assess different gene expression patterns between samples.
transcription profiling by array, co-expression, disease state, in vitro
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. Rajala HL, Eldfors S, Kuusanmäki H, van Adrichem AJ, Olson T, Lagström S, Andersson EI, Jerez A, Clemente MJ, Yan Y, Zhang D, Awwad A, Ellonen P, Kallioniemi O, Wennerberg K, Porkka K, Maciejewski JP, Loughran TP Jr, Heckman C, Mustjoki S. Blood (2013), Europe PMC 23596048