E-MTAB-1569 - Transcription profiling by array of mouse CD8 central memory T-cells derived from spleens of 7-month old PD-1 knockout or wild-type mice
Released on 6 May 2013, last updated on 23 December 2014
To test whether PD-1 exerts genome-wide gene expression changes in TCM-phenotype CD8 cells, we performed transcriptome analysis on TCM –phenotype CD8 cell subpopulations derived from 7-month old PD-1 KO and WT spleens.
transcription profiling by array, co-expression, ex vivo, individual genetic characteristics
Development of effector memory-phenotype CD8 T cells is negatively regulated by PD-1 in a cell-intrinsic manner. Joanna J. Charlton, Ioannis Chatzidakis, Debbie Tsoukatou, Dimitrios T. Boumpas, George A. Garinis, and Clio Mamalaki.