E-MTAB-1567 - Transcriptional profiling of rats treated with VX-765 and Anakinra

Status
Released on 10 December 2013, last updated on 3 May 2014
Organism
Rattus norvegicus
Samples (15)
Array (1)
Protocols (7)
Description
Various studies showed a significant production/release of IL-1 beta following status epilepticus (SE) and during epileptogenesis. We studied the role of this cytokine in the epileptogenic process by blocking its production and downstream effects in vivo in a model of acquired epilepsy following SE induction. We used a pharmacological strategy consisting of the administration of two drugs, namely VX-765 and Anakinra, which selectively block the biosynthesis and the receptor type 1 of this cytokine, respectively.
Experiment types
transcription profiling by array, compound treatment design
Contact
MIAME
PlatformsProtocolsFactorsProcessedRaw
Files
Investigation descriptionE-MTAB-1567.idf.txt
Sample and data relationshipE-MTAB-1567.sdrf.txt
Raw data (1)E-MTAB-1567.raw.1.zip
Processed data (1)E-MTAB-1567.processed.1.zip
Array designA-MEXP-2237.adf.txt
Links