E-MTAB-1567 - Transcriptional profiling of rats treated with VX-765 and Anakinra
Released on 10 December 2013, last updated on 3 May 2014
Various studies showed a significant production/release of IL-1 beta following status epilepticus (SE) and during epileptogenesis. We studied the role of this cytokine in the epileptogenic process by blocking its production and downstream effects in vivo in a model of acquired epilepsy following SE induction. We used a pharmacological strategy consisting of the administration of two drugs, namely VX-765 and Anakinra, which selectively block the biosynthesis and the receptor type 1 of this cytokine, respectively.
transcription profiling by array, compound treatment design