E-MTAB-1536 - Transcription profiling by array of human mesenchymal stem cells and endothelial cells to investigate down-regulation of cytokine-induced leukocyte recruitment
Released on 10 October 2013, last updated on 3 June 2014
This study aims to to compare the gene transcription profiles of endothelial cells and stem cells, when they are cultured alone or when they are cultured together. Thus there are two major questions - how do the cells differ, and how do the cells influence each other's gene expression. Thus there are 4 types of sample: endothelial cell monoculture, endothelial cell coculture, stem cells monoculture, stem cell coculture. There are also 4 biological replicates (independent experiments) leading to 16 array data files.
transcription profiling by array, cell type comparison, co-expression, in vitro
Crosstalk between mesenchymal stem cells and endothelial cells leads to down-regulation of cytokine-induced leukocyte recruitment. N. Thin Luu, Helen M. McGettrick, Christopher D. Buckley, Phil Newsome, G. Ed Rainger, Jon Frampton, Gerard B. Nash.