E-MTAB-1532 - Transcription profiling by array of whole blood samples from colorectal cancer patients and healthy individuals
Released on 3 May 2013, last updated on 3 June 2014
Colorectal cancer is the third most common malignancy and the fourth most common cause of cancer mortality worldwide. In 2008, more than one million cases were newly diagnosed, and more than 600,000 people died from the disease. Given its slow development from removable precancerous lesions and curable early stages, screening for CRC has the potential to reduce both the incidence and mortality of the disease. However, compliance with current screening methods remains poor and there is a clear need for an accurate in vitro blood test to increase participation in colorectal cancer screening. In this study, we performed genome-wide gene expression profiling of peripheral blood samples from 100 healthy controls and 100 colorectal cancer patients using PAXgeneTM technology and Affymetrix GeneChip® microarrays. We show that monitoring gene expression in blood results in distinct transcriptional profiles between the controls and cancer patients. Thus, the microarray-based blood gene expression profiling holds great promise for developing novel biomarkers for colorectal cancer detection.
transcription profiling by array, co-expression, disease state , in vitro
Identification and Validation of a Blood-Based 18-Gene Expression Signature in Colorectal Cancer. Xu Y, Xu Q, Yang L, Ye X, Liu F, Wu F, Ni S, Tan C, Cai G, Meng X, Cai S, Du X. Clin Cancer Res (2013), Europe PMC 23536436