E-MTAB-1521 - Transcription profiling by array of human prostate cancer cell lines to investigate drug targeting of the IL6/STAT3 pathway
Submitted on 6 February 2013, released on 24 April 2013, last updated on 3 May 2014
Prostate cancer is the most frequently diagnosed malignancy in adult males. Though multiple factors have been implicated in prostate cancer progression, the trigger for initiation of malignancy is still a topic of debate. Advanced age is the single most significant risk factor for prostate cancer. Epidemiological and clinical studies indicate oxidative stress as one of the major aging-associated influences on prostate carcinogenesis. In this study, for the first time, we demonstrated the intrinsic association of ROS and IL6/STAT3 in prostate carcinogenesis. The high levels of ROS/IL6/STAT3 activation in this carcinogenesis model will benefit understanding of the mechanism of prostate cancer initiation and progression, as well as therapeutic development of anti-cancer drug targeting of the IL6/STAT3 pathway.
transcription profiling by array, cell type comparison
Kjell Petersen <Kjell.Petersen@bccs.uib.no>, Anders Molven1,8, Anne M. Oyan1,2, Biaoyang Lin9,10,11, Emmet McCormack12, Jigang Zhang3, Karl A. Brokstad6, Karl-Henning Kalland1,2#, Mihaela Popa5, Randi Hovland4, Ronald Simon7, Runhui Liu3, Wei-dong Zhang3, Xi-Song Ke1#, Xiaojun Liu1,3, Yaping Hua1,3, Yi Qu1