E-MTAB-1508 - Methylation profiling by array of human chromosome 21 in placental chorionic villi of different gestational ages
Last updated on 28 March 2013, released on 29 March 2013
Tissue specific DNA methylation is present across many genomic elements, including large genomic regions. Most human tissues posses highly methylated genomes (>70%), but recent data has suggested the presence of partially methylated domains (PMDs) in some cell-lines. Placenta is a unique human tissue which has very different molecular properties than most tissues. It is the aim of this study to identify the presence/absence of PMDs in placental tissue and further define the DNA methylation landscape of the placenta. In particular this experiment is designed to look at the placental methylome across gestational ages in chromosome 21 to detect methylomic differences throughout development.
methylation profiling by array, all pairs, binding site identification, development or differentiation
The human placenta methylome. Diane I. Schroeder; John D. Blair; Paul Lott; Hung On Ken Yu; Danna Hong; Florence Crary; Paul Ashwood; Cheryl Walker; Ian Korf; Wendy P. Robinson; Janine M. LaSalle. Proc Natl Acad Sci U S A (2013), Europe PMC 23530188