E-MTAB-1481 - Transcription profiling by array of human K562 leukemia and MOLP8 multiple myeloma cell lines treated with HDAC inhibitor MG149 or HAT inhibitor SAHA against untreated controls
Released on 20 January 2014, last updated on 3 May 2014
Balance between histone acetylation and deacetylation is fundamental for proper gene function, thus knowledge of how to modulate these epigenetic processes is important for understanding of nuclear events, including replication, transcription, splicing and DNA repair. Here, we have studied an effect of HDAC inhibitor, SAHA, and we compared it with an effect of natural product, derivative of anacardic acid (MG149). Recently, it was discovered that MG149 has inhibitory potential for HATs' activity on histone H3 and H4 when tested on nuclear extracts.
transcription profiling by array, co-expression, compound treatment, dose response, in vitro
How basic nuclear processes are affected by selected HAT and HDAC inhibitors. Legartova S., Stixova L., Strnad H., Kozubek S., Martinet N., Dekker F., Bartova E.