E-MTAB-1470 - Transcription profiling by array of carotid endarterectomy samples collected from hypertensive patients to identify new biomarkers and to investigate pathways involved in the progression of human carotid atheroma
Last updated on 8 February 2013, released on 1 April 2013
The aim of this study was to identify new biomarkers and to investigate pathways involved in the progression of human carotid atheroma. The study was conducted from pieces of carotid endarterectomy collected in 32 hypertensive patients. The samples contained media and neo-intima without adventitia. They were paired, including for each patient one sample of the atheroma plaque (stage IV and over of the Stary classfication) containing core and shoulders of the plaque, and one sample of distant macroscopically intact tissue (stages I and II). In addition, clinical, biological and histological data were collected.
transcription profiling by array, all pairs, clinical history design, disease state design, ex-vivo, replicate design