E-MTAB-1469 - Transcription profiling by array of Myotonic dystrophy type 1 (DM1) Drosophila model in three different genetic contexts to assess the involvement of Mbl sequestration on transcriptpion deregulation in DM1
Released on 1 April 2013, last updated on 3 May 2014
Myotonic dystrophy type 1 (DM1) is a neuro-muscular disorder caused by CTG triplet expansion in the 3-UTR of the DMPK gene. Mutated transcripts aggregate in muscle nuclei and sequester the MBNL1 splicing factor. To assess the involvement of Mbl sequestration on transcriptpion deregulation in DM1, we performed genome wide analyses of gene expression of DM1 Drosophila model in three different genetic contexts: Mef>mblRNAi, Mef>600CTG, Mef>960CTG vs. Mef>lacZ control line.
transcription profiling by array, co-expression, disease state, reference
Novel Drosophila model of myotonic dystrophy type 1: phenotypic characterization and genome-wide view of altered gene expression. Lucie Picchio; Emilie Plantie; Yoan Renaud; Preethi Poovthumkadavil; Krzysztof Jagla. Hum Mol Genet , Europe PMC 23525904